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Review
Peer-Review Record

Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge

Biomolecules 2022, 12(8), 1070; https://doi.org/10.3390/biom12081070
by Ya Wang 1,2, Juanjuan Zhao 1,2, Shipeng Chen 1,2, Dongmei Li 1,2, Jing Yang 1,2, Xu Zhao 1,2, Ming Qin 1,2, Mengmeng Guo 1,2, Chao Chen 1,2, Zhixu He 3, Ya Zhou 1,4,* and Lin Xu 1,2,*
Reviewer 2:
Biomolecules 2022, 12(8), 1070; https://doi.org/10.3390/biom12081070
Submission received: 30 June 2022 / Revised: 28 July 2022 / Accepted: 29 July 2022 / Published: 2 August 2022

Round 1

Reviewer 1 Report

I have gone through the review article thoroughly. The author reviewed the recent studies highlighting Let-7 as a promising target in aging and aging-related diseases. The scope of the review is interesting. The article is nicely written and the authors provide nice figures to explain the role of the molecule. I feel this review is an important addition to the literature. This review provide new ideas for enriching the complex expression regulation mechanism and pathobiological function of let-7 in aging and related diseases. This will ultimately pro- 24 vide help for the development of new therapeutic strategies.

I recommend the paper for publication in Biomolecules

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

suggested minor edits:

 

1. line 42: C. elegans --> Caenorhabditis elegans

 

2. Line 44: " ,,, across animal species excluding plants." -->

 

3. Line 145: cryptobacterium hidradenum --> Cryptobacterium hidradenum

                                                                                               Italicize this

 

4.  Lines 153-158:  Indicate that Gendron et al. were studying Drosophila 

melanogaster.

 

Conclusion and Future directions.

... and muscle[113,115].  It regulates ... and related diseases.  Let-7 plays a 

critical role in aging and aging-related diseases.

 

What about future directions?  

 

 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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