Let-7 as a Promising Target in Aging and Aging-Related Diseases: A Promise or a Pledge
Round 1
Reviewer 1 Report
I have gone through the review article thoroughly. The author reviewed the recent studies highlighting Let-7 as a promising target in aging and aging-related diseases. The scope of the review is interesting. The article is nicely written and the authors provide nice figures to explain the role of the molecule. I feel this review is an important addition to the literature. This review provide new ideas for enriching the complex expression regulation mechanism and pathobiological function of let-7 in aging and related diseases. This will ultimately pro- 24 vide help for the development of new therapeutic strategies.
I recommend the paper for publication in Biomolecules
Author Response
Please see the attachment.
Author Response File: Author Response.docx
Reviewer 2 Report
suggested minor edits:
1. line 42: C. elegans --> Caenorhabditis elegans
2. Line 44: " ,,, across animal species excluding plants." -->
3. Line 145: cryptobacterium hidradenum --> Cryptobacterium hidradenum
Italicize this
4. Lines 153-158: Indicate that Gendron et al. were studying Drosophila
melanogaster.
Conclusion and Future directions.
... and muscle[113,115]. It regulates ... and related diseases. Let-7 plays a
critical role in aging and aging-related diseases.
What about future directions?
Author Response
Please see the attachment.
Author Response File: Author Response.docx