Zinc, Copper, and Calcium: A Triangle in the Synapse for the Pathogenesis of Vascular-Type Senile Dementia

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

This well-organized review describes the current understanding of the interactions between zinc and copper that may lead to neurodegeneration. The authors have drawn on their own work and the work of others to show mechanistic causes of disruptions in cellular calcium and alterations in gene expression involved in neuronal cell death pathways. This analysis has enabled them to develop a strong, testable hypothesis about the role of synergistic roles of copper, zinc, and calcium in the development of vascular dementia.   

Author Response

Response1: Thank you very very much for your warm comments to my article. Your comments are helpful to our work. Thank you again.

Reviewer 2 Report

Comments and Suggestions for Authors

Reviewing manuscript titled “Zinc, Copper, and Calcium: A Triangle in the Synapse for the Pathogenesis of Vascular-Type Senile Dementia”, authors discuss the roles of Zn and Cu in the synapse as well as the crosstalk between Zn, Cu, and Ca, which recent studies suggest may underlie the pathogenesis of vascular-type senile dementia.

In my opinion, this manuscript is quite well written, includes all relevant studies, and could be published after minor editing of English language.

Comments on the Quality of English Language

Minor editing of English language required

Author Response

Response2: Thank you very much for your comments. It was a great help for us. I have  asked to correct my English to native speakers in Edanz (https://jp.edanz.com/).    I also carefully checked my manuscript again and again, and corrected (corrected points are written in red). I hope owing to these correction, the manuscript become better.