Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective
Abstract
:1. Introduction
2. Materials and Methods
- I.
- Five years of molecular research on hip joint labrum, capsule, and synovial cellular senescence, with a total of 31 articles;
- II.
- Related research on similar molecular markers, totaling 51 articles;
- III.
- Perspectives, comprising 21 articles.
2.1. Five Years of Molecular Research on Hip Joint Labrum, Capsule, and Synovial Cellular Senescence
2.1.1. Hip Joint Labral Research
2.1.2. Hip Joint Capsule Research
2.1.3. Hip Joint Synovium Research
2.2. Related Research on Similar Molecular Markers
2.3. Perspectives
Author Contributions
Funding
Conflicts of Interest
References
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Article | Histology/Other | Biomolecule | Ultrastructural Association | IRM/CT Association/Other | H/AM | Statistics/ Scoring/ Scale | Aim |
---|---|---|---|---|---|---|---|
Antoniadis et al. [75] | ELISA/Explant culture/Alcian blue/Alizarin Red S | Pro/Pro-Col-Iα, IL-6, COMP/VEGF, ACAN | _ | Fluorescence imaging | H | Hierarchical clustering in ClustVis 1.0/GraphPad Prism/one-way ANOVA with Tukey’s multiple-comparison test/Mann–Whitney test and Friedman’s test with Dunn’s multiple-comparison test | Putative biomarkers of OA from explanted human labrum tissues under basal and inflammatory conditions |
Bay-Jensen et al. [76] | _ | CTX-II/TIMP | _ | _ | H | _ | Review of biomarkers derived from type II collagen and aggrecan |
Hasan et al. [77] | _ | TNFα/ TNF mRNA/TNFbeta/IL-1/IL-1b/ N-terminal-telopeptide (NTX) | _ | _ | H | ICROMS tool (integrated quality criteria for review of multiple study designs) | Review of blood and urine degenerative biomarkers |
Huang et al. [66] | Nanoparticles | VEGF/ SsDNA/CRISPR/Cas12a | _ | Fluorescence spectroscopy | H | _ | Rapid detection of ssDNA molecules |
Koyama et al. [78] | Real-time polymerase chain reaction (PCR) | RNA/TNFA/IL1B/IL6/COX2 mRNA | _ | _ | H | SPSS version 19.0 | Compare synovial tissue’s inflammatory cytokine levels |
Lynch et al. [79] | _ | COMP | _ | _ | H | Fixed-effect inverse-variance model | Review of COMP |
Mobasheri et al. [80] | _ | Collagen | _ | _ | H | _ | Review of glycosylation of collagens |
Nogami et al. [65] | Hematoxylin and eosin (HE) and Alcian blue (AB) | Collagen I and II | Collagen I and II | _ | H | _ | Ultrastructure of collagen fibers |
Oppl et al. [81] | ELISA—enzyme-linked immunosorbent assay | VCAM-1 | _ | _ | H | Clinical future prediction model development | |
Osashi et al. [82] | PCR | RNA | _ | _ | H | G∗POWER3 | NGF-expressing cells/mRNA expression of NGF, CD14, and CD90 |
Sato et al. [55] | Hematoxylin and eosin | Anti-VEGF/ Anti-NGF/ ISOGEN reagent | _ | _ | H | Krenn score/ Kellgren–Lawrence grade/ Harris Hip Score/ Spearman’s correlation analysis | VEGF and NGF expression levels |
Schon et al. [83] | HE/ Picrosirius Red | MMPs/TIMPs | _ | _ | H | Mann–Whitney U test | Expression profile of matrix metalloproteinases |
Stattin et al. [84] | Cell culture/Recombinant protein expression | ACAN gene (NM_00135.2, NM_013227.2) | _ | Chemiluminescent detection and documentation (Bio-Rad ChemiDoc MP) | H | Affinity Design 1.7 software | ACAN variants linked to hereditary skeletal disorders |
Wang et al. [85] | _ | Serum 25-hydroxyvitamin D | _ | _ | H | Categorical analysis, heterogeneity checks, publication bias analysis, and subgroup analyses | Review 25-(H)D |
Article | Histology/Other | Biomolecule | Ultrastructural Association | IRM/CT Association/Other | H/AM | Statistics/ Scoring/ Scale | Aim |
---|---|---|---|---|---|---|---|
Jiang et al. [92] | Cell cultures/chromatography via an ALP detection kit/chromatography using a hydroxyproline detection kit/PCR | Cbfa1α sense/Cbfa1α anti-sense/OCα sense/OCα anti-sense/BMPR-I/BMPR-II/Smad1/Smad5/phosphorylated (p) Smad1/pSmad5/Smad4/Smad6/Cbfa1 | Osteogenic disparity characteristics of fibroblasts in hip joint capsule | ||||
Li et al. [72] | Cell cycle, viability, apoptosis, immunofluorescence, reverse transcription polymerase chain reaction/RT-PCR/Western blotting | COL1A1/COL3A1/MMP1/MMP3/MMP9/MMP13/TGF-β1/TGF-β2/SMAD3/WNT11/αSMA/CCNB1/CCNE2/CCNA2/CDK1/E2F1/CDC6/CDC7 | _ | _ | H | Unpaired two-tailed t-test with GraphPad Prism software, USA | Molecular changes in hip dysplasia |
Zhang et al. [93] | Monoclonal rabbit anti-human collagen I/rabbit anti-human collagen III antibody/qPCR RT | X-ray imaging | Tonnis’ classification of hip dislocation/statistical software SPSS 16.0/two-tailed Student’s t-tests | Roles of collagen I and III in the hip capsule | |||
Zhao et al. [87] | HE/MASSON | DNBelab C Series Single-Cell Library Prep Kit/Metabolic genes | _ | _ | H | clusterProfiler R package/pseudotemporal analysis | Receptor-like cells and ligament stem cells |
Article | Histology/Other | Biomolecule | UA | IRM/CT Association/Other | H/AM | Statistics/ Scoring/ Scale | Aim |
---|---|---|---|---|---|---|---|
Batushansky et al. [107] | Liquid chromatography/gas chromatography–mass spectrometry | Glycine/histidine, lysophospholipid LPC/hypoxanthine/homocysteine/urate/tryptophan/fructose/citrate/malate/methionine/3-hydroxybutyrate | _ | _ | H | BIPED classification model of OA biomarkers | Review to relate metabolic syndrome to synovium pathology |
Carlson et al. [108] | High-performance liquid chromatography–mass spectrometry (LC-MS) | Glycine/serine/alanine/threonine/lysine, arginine/proline/urea cycle/phosphatidylinositol phosphate metabolism/carnitine shuttle/vitamin metabolism (B5 and C)/porphyrin metabolism | _ | _ | H | MetaboAnalyst/Kolmogorov–Smirnov test (KS-test)/HCA/Mummichog/Volcano plot analysis | Metabolomic phenotypes from human synovial fluid |
Coryell et al. [106] | _ | SA-β-Gal production/p16 expression/EV secretion | _ | _ | H | _ | Review of phenotypes associated with cellular senescence |
Haubruck et al. [99] | _ | Monocyte/Macrophage | _ | _ | H | _ | Review of synovial in situ dynamics of joint macrophages and monocytes |
Liu et al. [1] | _ | GATA/STINGFOXD1/SIRT6/DGCR8 | _ | _ | H | _ | Systematic review/chondrocyte senescence/senescent fibroblast-like synoviocytes |
Kim et al. [109] | Gas chromatography/time-of-flight mass spectrometry | Hypoxanthine/xanthine/adenosine/citrulline/histidine/tryptophan | _ | _ | H | MetaboAnalyst | RA and OA metabolomic differentiation |
Koyama et al. [78] | Real-time polymerase chain reaction (PCR) | RNA/TNFA/IL1B/IL6/COX2 mRNA | _ | _ | H | SPSS version 19.0 | Compare synovial tissue inflammatory cytokine levels |
Laus et al. [110] | 1H-NMR | Tryptophan/phenylalanine/tyrosine/glycine/asparagine/glutamine/arginine/methionine/1,3-Dihydroxyacetone | _ | _ | NH | Box–Cox transformation/t-test | Metabolomic phenotypes from horse synovial fluid |
MurilloSaich et al. [111] | HE/ELISA | CD68/Vimentin/TNF/CXCL2/ CCL2/MMP13 | _ | A 600 MHz Bruker Avance III spectrometer 1 H NMR | H | Krenn OPLS-DA/VIP | Potential metabolomic biomarkers of joint injury in synovial fluid and serum |
Stabile et al. [112] | 1H-NMR | Isoleucine/leucine/valine/β-hydroxybutyrate/threonine/alanine/glutamine/methionine/lactate/acetate/acetoacetate/pyruvate/citrate/creatine/creatinine/β-glucose/TMAO/lactate/histidine/phenylalanine/tyrosine/formic acid | _ | _ | NH | R Statistic software/unsupervised PCA, HCA/supervised OPLS-DA | Metabolomic phenotypes from canine synovial fluid |
Yang et al. [113] | _ | RNA/RT-qPCR/synovial mesenchymal stem cells/VEGF/MMP9 | _ | _ | H | R software/GraphPad Prism/Shapiro–Wilk test | Characteristics of the synovium in OA |
Wallace et al. [114] | High-performance liquid chromatography | GAG monomers/steroid hormones/NADPH | _ | _ | NH | MetaboAnalyst/hierarchical cluster analysis | Potential metabolomic biomarkers of joint injury in synovial fluid and serum |
Zhan et al. [115] | Mass spectrometry | Geniposide-related biomarkers | _ | _ | H | MetaboAnalyst/hierarchical cluster analysis | Potential metabolomic biomarkers of joint injury in synovial fluid |
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Huzum, R.M.; Hînganu, M.V.; Huzum, B.; Hînganu, D. Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective. Biomolecules 2024, 14, 784. https://doi.org/10.3390/biom14070784
Huzum RM, Hînganu MV, Huzum B, Hînganu D. Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective. Biomolecules. 2024; 14(7):784. https://doi.org/10.3390/biom14070784
Chicago/Turabian StyleHuzum, Riana Maria, Marius Valeriu Hînganu, Bogdan Huzum, and Delia Hînganu. 2024. "Advances in Molecular Research on Hip Joint Impingement—A Vascular Perspective" Biomolecules 14, no. 7: 784. https://doi.org/10.3390/biom14070784