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Review

The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review

1
Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
2
Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
3
Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
4
Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
5
Department of Gastrointestinal Surgery, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China
6
Institute of Molecular Precision Medicine and Hunan Key Laboratory of Molecular Precision Medicine, Xiangya Hospital, Central South University, Changsha 410008, China
*
Authors to whom correspondence should be addressed.
Biomolecules 2024, 14(7), 874; https://doi.org/10.3390/biom14070874 (registering DOI)
Submission received: 9 May 2024 / Revised: 16 July 2024 / Accepted: 18 July 2024 / Published: 20 July 2024

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. The unlimited proliferation of tumor cells is one of the key features resulting in the malignant development and progression of CRC. Consequently, understanding the potential proliferation and growth molecular mechanisms and developing effective therapeutic strategies have become key in CRC treatment. Pyroptosis is an emerging type of regulated cell death (RCD) that has a significant role in cells proliferation and growth. For the last few years, numerous studies have indicated a close correlation between pyroptosis and the occurrence, progression, and treatment of many malignancies, including CRC. The development of effective therapeutic strategies to inhibit tumor growth and proliferation has become a key area in CRC treatment. Thus, this review mainly summarized the different pyroptosis pathways and mechanisms, the anti-tumor (tumor suppressor) and protective roles of pyroptosis in CRC, and the clinical and prognostic value of pyroptosis in CRC, which may contribute to exploring new therapeutic strategies for CRC.
Keywords: pyroptosis; colorectal cancer; proliferation; growth; therapy pyroptosis; colorectal cancer; proliferation; growth; therapy

Share and Cite

MDPI and ACS Style

Fang, Q.; Xu, Y.; Tan, X.; Wu, X.; Li, S.; Yuan, J.; Chen, X.; Huang, Q.; Fu, K.; Xiao, S. The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review. Biomolecules 2024, 14, 874. https://doi.org/10.3390/biom14070874

AMA Style

Fang Q, Xu Y, Tan X, Wu X, Li S, Yuan J, Chen X, Huang Q, Fu K, Xiao S. The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review. Biomolecules. 2024; 14(7):874. https://doi.org/10.3390/biom14070874

Chicago/Turabian Style

Fang, Qing, Yunhua Xu, Xiangwen Tan, Xiaofeng Wu, Shuxiang Li, Jinyi Yuan, Xiguang Chen, Qiulin Huang, Kai Fu, and Shuai Xiao. 2024. "The Role and Therapeutic Potential of Pyroptosis in Colorectal Cancer: A Review" Biomolecules 14, no. 7: 874. https://doi.org/10.3390/biom14070874

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