Effects of Interrupting Prolonged Sitting with Light-Intensity Physical Activity on Inflammatory and Cardiometabolic Risk Markers in Young Adults with Overweight and Obesity: Secondary Outcome Analyses of the SED-ACT Randomized Controlled Crossover Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Eligibility Criteria
2.2. Study Design
2.3. Screening Visit
2.4. Trial Visits
2.5. Blood Sampling
2.6. Inflammatory and Cardiometabolic Risk Markers
2.7. Statistics
3. Results
3.1. Results of the Screening Visit
3.2. Results of the Trial Visits
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Characteristics | Mean (95% CI, n = 17) | Inflammatory and Cardiometabolic Risk Markers | Mean (95% CI, n = 17) |
---|---|---|---|
Females (n [%]) * | 8 (47.1) | IL-6 (pg/mL) | 3.2 (1.7–4.8) |
Age (years) | 23.4 (21.7–25.0) | CRP (mg/L | 2.6 (0.7–4.5) |
Height (cm) | 173.8 (167.5–180.0) | TC (mg/dL) | 180.0 (166.2–192.7) |
Weight (kg) | 90.1 (80.7–99.5) | HDL-C (mg/dL) | 54.1 (47.9–60.2) |
BMI (kg/m2) | 29.7 (27.8–31.6) | LDL-C (mg/dL | 103.0 (90.9–114.8) |
Body Composition | TG (mg/dL) | 112.6 (92.7–132.5) | |
ICW (L) | 28.3 (24.7–31.8) | TC/HDL-C (mg/dL) | 3.4 (3.1–3.8) |
ECW (L) | 16.8 (14.7–18.9) | TG/HDL-C (mg/dL) | 2.2 (1.7–2.7) |
TBW (L) | 45.1 (39.4–50.8) | LDL-C/HDL-C (mg/dL) | 2.0 (1.7–2.3) |
FM (kg) | 29.2 (23.9–34.4) | TyG index (mg/dL) | 8.4 (8.2–8.6) |
FM (%) | 31.8 (27.6–36.0) | Albumin (g/dL) | 4.9 (4.7–5.0) |
SMM (kg) | 34.9 (30.2–39.5) | Amylase, pancreatic (U/L) | 24.3 (20.3–28.4) |
SMM (%) | 38.6 (36.0–41.1) | Protein, total (g/dL) | 7.6 (7.4–7.7) |
VFA (cm2) | 119.2 (101.7–136.7) | Uric acid (mg/dL) | 5.8 (5.2–6.4) |
BMR (kcal) | 1700.0 (1531.0–1868.0) | Urea (mg/dL) | 24.3 (20.8–27.8) |
Creatinine (mg/dL) | 0.9 (0.8–1.0) |
Age (Years) | BMI (kg/m2) | FM (%) | SMM (%) | VFA (cm2) | |
---|---|---|---|---|---|
IL-6 (pg/mL) | 0.266 | 0.510 | 0.297 | 0.183 | 0.583 |
(0.298) | (0.039 *) | (0.245) | (0.478) | (0.016 *) | |
CRP (mg/L) | 0.475 | 0.319 | 0.070 | 0.057 | 0.460 |
(0.056) | (0.209) | (0.788) | (0.827) | (0.065) | |
TC (mg/dL) | 0.020 | −0.144 | −0.120 | −0.211 | −0.213 |
(0.941) | (0.661) | (0.645) | (0.415) | (0.410) | |
HDL-C (mg/dL) | −0.168 | −0.087 | 0.369 | 0.154 | −0.178 |
(0.513) | (0.735) | (0.145) | (0.554) | (0.491) | |
LDL-C (mg/dL) | −0.040 | −0.129 | −0.417 | −0.238 | −0.218 |
(0.877) | (0.6202) | (0.096) | (0.357) | (0.399) | |
TG (mg/dL) | 0.088 | 0.396 | 0.177 | 0.137 | 0.580 |
(0.733) | (0.116) | (0.497) | (0.599) | (0.015 *) | |
TC/HDL-C (mg/dL) | 0.103 | −0.018 | −0.392 | −0.290 | 0.061 |
(0.694) | (0.945) | (0.119) | (0.259) | (0.815) | |
TG/HDL-C (mg/dL) | 0.232 | 0.338 | 0.048 | 0.104 | 0.563 |
(0.371) | (0.184) | (0.856) | (0.690) | (0.019 *) | |
LDL-C/HDL-C (mg/dL) | 0.070 | −0.147 | −0.481 | −0.355 | −0.117 |
(0.788) | (0.577) | (0.051) | (0.162) | (0.654) | |
TyG index (mg/dL) | 0.162 | 0.142 | 0.059 | 0.212 | 0.412 |
(0.536) | (0.586) | (0.823) | (0.415) | (0.100) | |
Albumin (g/dL) | 0.061 | 0.276 | −0.235 | 0.171 | 0.272 |
(0.815) | (0.283) | (0.364) | (0.513) | (0.292) | |
Amylase, pancreatic (U/L) | 0.218 | −0.083 | −0.193 | −0.434 | −0.085 |
(0.401 | (0.753) | (0.458) | (0.082) | (0.747) | |
Protein, total (g/dL) | 0.103 | 0.578 | −0.055 | 0.241 | 0.514 |
(0.696) | (0.015 *) | (0.835) | (0.352) | (0.035 *) | |
Uric acid (mg/dL) | 0.500 | 0.335 | −0.327 | −0.060 | 0.406 |
(0.041 *) | (0.189) | (0.199) | (0.820) | (0.106) | |
Urea (mg/dL) | −0.405 | −0.072 | −0.188 | −0.326 | −0.078 |
(0.107) | (0.785) | (0.469) | (0.202) | (0.764) | |
Creatinine (mg/dL) | 0.143 | 0.056 | −0.513 | −0.396 | 0.100 |
(0.585) | (0.831) | (0.035 *) | (0.116) | (0.702) |
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Hoffmann, S.W.; Schierbauer, J.; Zimmermann, P.; Voit, T.; Grothoff, A.; Wachsmuth, N.B.; Rössler, A.; Niedrist, T.; Lackner, H.K.; Moser, O. Effects of Interrupting Prolonged Sitting with Light-Intensity Physical Activity on Inflammatory and Cardiometabolic Risk Markers in Young Adults with Overweight and Obesity: Secondary Outcome Analyses of the SED-ACT Randomized Controlled Crossover Trial. Biomolecules 2024, 14, 1029. https://doi.org/10.3390/biom14081029
Hoffmann SW, Schierbauer J, Zimmermann P, Voit T, Grothoff A, Wachsmuth NB, Rössler A, Niedrist T, Lackner HK, Moser O. Effects of Interrupting Prolonged Sitting with Light-Intensity Physical Activity on Inflammatory and Cardiometabolic Risk Markers in Young Adults with Overweight and Obesity: Secondary Outcome Analyses of the SED-ACT Randomized Controlled Crossover Trial. Biomolecules. 2024; 14(8):1029. https://doi.org/10.3390/biom14081029
Chicago/Turabian StyleHoffmann, Sascha W., Janis Schierbauer, Paul Zimmermann, Thomas Voit, Auguste Grothoff, Nadine B. Wachsmuth, Andreas Rössler, Tobias Niedrist, Helmut K. Lackner, and Othmar Moser. 2024. "Effects of Interrupting Prolonged Sitting with Light-Intensity Physical Activity on Inflammatory and Cardiometabolic Risk Markers in Young Adults with Overweight and Obesity: Secondary Outcome Analyses of the SED-ACT Randomized Controlled Crossover Trial" Biomolecules 14, no. 8: 1029. https://doi.org/10.3390/biom14081029