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Review

Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer

1
Department of Pharmacy, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China
2
Institute of Medical Research, Northwestern Polytechnical University, Xi’an 710072, China
3
Department of Science and Education, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China
*
Author to whom correspondence should be addressed.
Biomolecules 2024, 14(8), 917; https://doi.org/10.3390/biom14080917 (registering DOI)
Submission received: 10 July 2024 / Revised: 21 July 2024 / Accepted: 25 July 2024 / Published: 27 July 2024

Abstract

Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores the interplay between intratumoral microbiota, tumor metabolism, and major types of GI cancers (including esophageal, gastric, liver, pancreatic, and colorectal cancers), summarizing recent studies and elucidating their clinical implications and future directions. Recent research revealed altered microbial signatures within GI tumors, impacting tumor progression, immune responses, and treatment outcomes. Dysbiosis-induced alterations in tumor metabolism, including glycolysis, fatty acid metabolism, and amino acid metabolism, play critical roles in cancer progression and therapeutic resistance. The integration of molecular mechanisms and potential biomarkers into this understanding further enhances the prognostic significance of intratumoral microbiota composition and therapeutic opportunities targeting microbiota-mediated tumor metabolism. Despite advancements, challenges remain in understanding the dynamic interactions within the tumor microenvironment (TME). Future research directions, including advanced omics technologies and prospective clinical studies, offer promising avenues for precision oncology and personalized treatment interventions in GI cancer. Overall, integrating microbiota-based approaches and molecular biomarkers into GI cancer management holds promise for improving patient outcomes and survival.
Keywords: intratumoral microbiota; gastrointestinal cancer; microbial biomarkers; tumor metabolism; tumor microenvironment intratumoral microbiota; gastrointestinal cancer; microbial biomarkers; tumor metabolism; tumor microenvironment

Share and Cite

MDPI and ACS Style

Bi, X.; Wang, J.; Liu, C. Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer. Biomolecules 2024, 14, 917. https://doi.org/10.3390/biom14080917

AMA Style

Bi X, Wang J, Liu C. Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer. Biomolecules. 2024; 14(8):917. https://doi.org/10.3390/biom14080917

Chicago/Turabian Style

Bi, Xueyuan, Jihan Wang, and Cuicui Liu. 2024. "Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer" Biomolecules 14, no. 8: 917. https://doi.org/10.3390/biom14080917

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