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Review

Epigenetic Modifiers in Cancer Metastasis

1
Key Laboratory of Molecular Genetics between Kangda College of Nanjing Medical University and Suzhou Medical College of Soochow University, Suzhou 215123, China
2
Department of Basic Medicine, Kangda College of Nanjing Medical University, Lianyungang 222000, China
3
Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China
4
Laboratory Animal Center, Suzhou Medical College of Soochow University, Suzhou 215123, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2024, 14(8), 916; https://doi.org/10.3390/biom14080916 (registering DOI)
Submission received: 3 June 2024 / Revised: 18 July 2024 / Accepted: 25 July 2024 / Published: 27 July 2024
(This article belongs to the Section Cellular Biochemistry)

Abstract

Metastasis is the primary cause of cancer-related death, with the dissemination and colonization of primary tumor cells at the metastatic site facilitated by various molecules and complex pathways. Understanding the biological mechanisms underlying the metastatic process is critical for the development of effective interventions. Several epigenetic modifications have been identified that play critical roles in regulating cancer metastasis. This review aims to provide a comprehensive summary of recent advances in understanding the role of epigenetic modifiers, including histone modifications, DNA methylation, non-coding RNAs, enhancer reprogramming, chromatin accessibility, and N6-methyladenosine, in metastasis-associated processes, such as epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion. In particular, this review provides a detailed and in-depth description of the role of crosstalk between epigenetic regulators in tumor metastasis. Additionally, we explored the potential and limitations of epigenetics-related target molecules in the diagnosis, treatment, and prognosis of cancer metastasis.
Keywords: epigenetics; DNA methylation; histone methylation; non-coding RNAs; metastasis epigenetics; DNA methylation; histone methylation; non-coding RNAs; metastasis

Share and Cite

MDPI and ACS Style

Hu, D.; Zhao, T.; Xu, C.; Pan, X.; Zhou, Z.; Wang, S. Epigenetic Modifiers in Cancer Metastasis. Biomolecules 2024, 14, 916. https://doi.org/10.3390/biom14080916

AMA Style

Hu D, Zhao T, Xu C, Pan X, Zhou Z, Wang S. Epigenetic Modifiers in Cancer Metastasis. Biomolecules. 2024; 14(8):916. https://doi.org/10.3390/biom14080916

Chicago/Turabian Style

Hu, Die, Tianci Zhao, Chenxing Xu, Xinyi Pan, Zhengyu Zhou, and Shengjie Wang. 2024. "Epigenetic Modifiers in Cancer Metastasis" Biomolecules 14, no. 8: 916. https://doi.org/10.3390/biom14080916

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