This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessReview
Epigenetic Modifiers in Cancer Metastasis
by
Die Hu
Die Hu 1,2,†,
Tianci Zhao
Tianci Zhao 3,†,
Chenxing Xu
Chenxing Xu 2,
Xinyi Pan
Xinyi Pan 2,
Zhengyu Zhou
Zhengyu Zhou 4,* and
Shengjie Wang
Shengjie Wang 1,2,4,*
1
Key Laboratory of Molecular Genetics between Kangda College of Nanjing Medical University and Suzhou Medical College of Soochow University, Suzhou 215123, China
2
Department of Basic Medicine, Kangda College of Nanjing Medical University, Lianyungang 222000, China
3
Key Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang 110122, China
4
Laboratory Animal Center, Suzhou Medical College of Soochow University, Suzhou 215123, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2024, 14(8), 916; https://doi.org/10.3390/biom14080916 (registering DOI)
Submission received: 3 June 2024
/
Revised: 18 July 2024
/
Accepted: 25 July 2024
/
Published: 27 July 2024
Abstract
Metastasis is the primary cause of cancer-related death, with the dissemination and colonization of primary tumor cells at the metastatic site facilitated by various molecules and complex pathways. Understanding the biological mechanisms underlying the metastatic process is critical for the development of effective interventions. Several epigenetic modifications have been identified that play critical roles in regulating cancer metastasis. This review aims to provide a comprehensive summary of recent advances in understanding the role of epigenetic modifiers, including histone modifications, DNA methylation, non-coding RNAs, enhancer reprogramming, chromatin accessibility, and N6-methyladenosine, in metastasis-associated processes, such as epithelial-mesenchymal transition (EMT), cancer cell migration, and invasion. In particular, this review provides a detailed and in-depth description of the role of crosstalk between epigenetic regulators in tumor metastasis. Additionally, we explored the potential and limitations of epigenetics-related target molecules in the diagnosis, treatment, and prognosis of cancer metastasis.
Share and Cite
MDPI and ACS Style
Hu, D.; Zhao, T.; Xu, C.; Pan, X.; Zhou, Z.; Wang, S.
Epigenetic Modifiers in Cancer Metastasis. Biomolecules 2024, 14, 916.
https://doi.org/10.3390/biom14080916
AMA Style
Hu D, Zhao T, Xu C, Pan X, Zhou Z, Wang S.
Epigenetic Modifiers in Cancer Metastasis. Biomolecules. 2024; 14(8):916.
https://doi.org/10.3390/biom14080916
Chicago/Turabian Style
Hu, Die, Tianci Zhao, Chenxing Xu, Xinyi Pan, Zhengyu Zhou, and Shengjie Wang.
2024. "Epigenetic Modifiers in Cancer Metastasis" Biomolecules 14, no. 8: 916.
https://doi.org/10.3390/biom14080916
Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details
here.
Article Metrics
Article metric data becomes available approximately 24 hours after publication online.