Plectin: Dual Participation in Tumor Progression
Abstract
:1. Introduction
2. Molecular Structure and Function of Plectin
3. The Role of Plectin in Tumor Initiation and Progression
3.1. Plectin Promotes Cancer Development
3.2. Plectin Inhibits Cancer Development
4. Summary and Perspective
Author Contributions
Funding
Conflicts of Interest
References
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Tumor Types | Outcomes | Signal Molecules | Refs. |
---|---|---|---|
HNSCC | Increased proliferation, migration, and invasion | Erk1/2 | [8] |
OSCC | Increased migration, invasion, tumorigenicity and levels of F-actin | Integrin β4, Cdc42, F-actin, Arp 2/3, MMP-9, NDRG1 | [46,49] |
Colon cancer | Increased migration, invasion and adhesion | Actin | [16] |
ESCC | Promotes the occurrence of ESCC | Caspase-8 | [56] |
IPMN | Enhances the malignance | Unknown | [61] |
PDAC | Increased migration and invasion; a specific marker | BRCA2 | [11] |
Prostate cancer | Increased growth, metastasis, invasion and colony formation | Clusterin, NNMT, QARS, RPS2, RPLP0, GRHPR, GlnRS, Actin, Glutamine | [6] |
HCC | Increased migration, invasion and EMT | Erk1/2 | [60] |
Melanoma | Increased proliferation, Src activity and cell adhesion | Src | [63] |
Bladder cancer | Increased migration, invasion and metastases | Vimentin, Cortactin, F-actin, MMPs | [64] |
Lung adenocarcinoma | Increased migration and invasion | Erk1/2 | [70] |
Ovarian cancer | Increased invasion | Actin | [68] |
Tumor types | Outcomes | Signal Molecules | Refs. |
---|---|---|---|
HCC | Increases cell motility and causes pleomorphism of cancer cells | FAK, Rac1-GTPase | [12,13] |
BCC | Increases invasion and metastasis | Integrin α6β4 | [14] |
SCC | |||
Situ skin carcinomas | |||
Breast cancer | Promotes nuclear centrosome dissociation and micronucleus formation | BRCA2, centrosome | [71] |
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Wang, Z.; Wang, W.; Luo, Q.; Song, G. Plectin: Dual Participation in Tumor Progression. Biomolecules 2024, 14, 1050. https://doi.org/10.3390/biom14091050
Wang Z, Wang W, Luo Q, Song G. Plectin: Dual Participation in Tumor Progression. Biomolecules. 2024; 14(9):1050. https://doi.org/10.3390/biom14091050
Chicago/Turabian StyleWang, Zhihui, Wenbin Wang, Qing Luo, and Guanbin Song. 2024. "Plectin: Dual Participation in Tumor Progression" Biomolecules 14, no. 9: 1050. https://doi.org/10.3390/biom14091050