Bringing Vitamin D and the Vitamin D Receptor into the Limelight
Funding
Conflicts of Interest
References
- Sun, J.; Zhang, Y.G. Vitamin D Receptor Influences Intestinal Barriers in Health and Disease. Cells 2022, 11, 1129. [Google Scholar] [CrossRef] [PubMed]
- Ismailova, A.; White, J.H. Vitamin D, infections and immunity. Rev. Endocr. Metab. Disord. 2022, 23, 265–277. [Google Scholar] [CrossRef] [PubMed]
- Wu, S.; Sun, J. Vitamin D, vitamin D receptor, and macroautophagy in inflammation and infection. Discov. Med. 2011, 11, 325–335. [Google Scholar] [PubMed]
- Demay, M.B.; Pittas, A.G.; Bikle, D.D.; Diab, D.L.; Kiely, M.E.; Lazaretti-Castro, M.; Lips, P.; Mitchell, D.M.; Murad, M.H.; Powers, S.; et al. Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2024, 109, 1907–1947. [Google Scholar] [CrossRef]
- Dimitrov, V.; Barbier, C.; Ismailova, A.; Wang, Y.; Dmowski, K.; Salehi-Tabar, R.; Memari, B.; Groulx-Boivin, E.; White, J.H. Vitamin D-regulated Gene Expression Profiles: Species-specificity and Cell-specific Effects on Metabolism and Immunity. Endocrinology 2021, 162, bqaa218. [Google Scholar] [CrossRef]
- Bakke, D.; Sun, J. Ancient Nuclear Receptor VDR with New Functions: Microbiome and Inflammation. Inflamm. Bowel Dis. 2018, 24, 1149–1154. [Google Scholar] [CrossRef]
- Wang, J.; Thingholm, L.B.; Skieceviciene, J.; Rausch, P.; Kummen, M.; Hov, J.R.; Degenhardt, F.; Heinsen, F.A.; Ruhlemann, M.C.; Szymczak, S.; et al. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat. Genet. 2016, 48, 1396–1406. [Google Scholar] [CrossRef]
- Zhang, Y.G.; Lu, R.; Wu, S.; Chatterjee, I.; Zhou, D.; Xia, Y.; Sun, J. Vitamin D Receptor Protects Against Dysbiosis and Tumorigenesis via the JAK/STAT Pathway in Intestine. Cell Mol. Gastroenterol. Hepatol. 2020, 10, 729–746. [Google Scholar] [CrossRef]
- Giampazolias, E.; Pereira da Costa, M.; Lam, K.C.; Lim, K.H.J.; Cardoso, A.; Piot, C.; Chakravarty, P.; Blasche, S.; Patel, S.; Biram, A.; et al. Vitamin D regulates microbiome-dependent cancer immunity. Science 2024, 384, 428–437. [Google Scholar] [CrossRef]
- Lu, R.; Zhang, Y.G.; Xia, Y.; Zhang, J.; Kaser, A.; Blumberg, R.; Sun, J. Paneth Cell Alertness to Pathogens Maintained by Vitamin D Receptors. Gastroenterology 2021, 160, 1269–1283. [Google Scholar] [CrossRef]
- Wu, S.; Zhang, Y.G.; Lu, R.; Xia, Y.; Zhou, D.; Petrof, E.O.; Claud, E.C.; Chen, D.; Chang, E.B.; Carmeliet, G.; et al. Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis. Gut 2015, 64, 1082–1094. [Google Scholar] [CrossRef]
- Zhang, Y.G.; Wu, S.; Sun, J. Vitamin D, Vitamin D Receptor, and Tissue Barriers. Tissue Barriers 2013, 1, e23118. [Google Scholar] [CrossRef] [PubMed]
- Mavar, M.; Soric, T.; Bagaric, E.; Saric, A.; Matek Saric, M. The Power of Vitamin D: Is the Future in Precision Nutrition through Personalized Supplementation Plans? Nutrients 2024, 16, 1176. [Google Scholar] [CrossRef] [PubMed]
- Elmelid, A.; Siekkeri Vandikas, M.; Gillstedt, M.; Osmancevic, A.; Alsterholm, M. The Effect of Narrow-Band Ultraviolet B Phototherapy on Free and Total Vitamin D Serum Levels in Mild to Severe Plaque Psoriasis. Biomolecules 2023, 13, 1018. [Google Scholar] [CrossRef] [PubMed]
- Bastyte, D.; Tamasauskiene, L.; Stakaitiene, I.; Ugenskiene, R.; Gradauskiene Sitkauskiene, B. The Association of Vitamin D Receptor Gene Polymorphisms with Vitamin D, Total IgE, and Blood Eosinophils in Patients with Atopy. Biomolecules 2024, 14, 212. [Google Scholar] [CrossRef]
- Kristjansson, K.; Rut, A.R.; Hewison, M.; O’Riordan, J.L.; Hughes, M.R. Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3. J. Clin. Investig. 1993, 92, 12–16. [Google Scholar] [CrossRef]
- Zhao, X.; Bridgman, S.L.; Drall, K.M.; Tun, H.M.; Mandhane, P.J.; Moraes, T.J.; Simons, E.; Turvey, S.E.; Subbarao, P.; Scott, J.A.; et al. Infant Vitamin D Supplements, Fecal Microbiota and Their Metabolites at 3 Months of Age in the CHILD Study Cohort. Biomolecules 2023, 13, 200. [Google Scholar] [CrossRef]
- Sharma, A.; Yu, Y.; Lu, J.; Lu, L.; Zhang, Y.G.; Xia, Y.; Sun, J.; Claud, E.C. The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life. Biomolecules 2023, 13, 847. [Google Scholar] [CrossRef]
- Szabo, T.M.; Nagy, E.E.; Kirchmaier, A.; Heidenhoffer, E.; Gabor-Kelemen, H.L.; Frasineanu, M.; Cseke, J.; German-Sallo, M.; Frigy, A. Total 25-Hydroxyvitamin D Is an Independent Marker of Left Ventricular Ejection Fraction in Heart Failure with Reduced and Mildly Reduced Ejection Fraction. Biomolecules 2023, 13, 1578. [Google Scholar] [CrossRef]
- Battaglia, Y.; Bellasi, A.; Esposito, P.; Bortoluzzi, A.; Rotondi, S.; Andreucci, M.; Fiorini, F.; Russo, D.; Storari, A. The Impact of Cholecaciferol Supplementation on Bone Mineral Density in Long-Term Kidney Transplant Recipients. Biomolecules 2023, 13, 629. [Google Scholar] [CrossRef]
- Crafa, A.; Cannarella, R.; Barbagallo, F.; Leanza, C.; Palazzolo, R.; Flores, H.A.; La Vignera, S.; Condorelli, R.A.; Calogero, A.E. Mechanisms Suggesting a Relationship between Vitamin D and Erectile Dysfunction: An Overview. Biomolecules 2023, 13, 930. [Google Scholar] [CrossRef]
- Peluso-Iltis, C.; Pierrat, N.; Rovito, D.; Osz, J.; Sawada, D.; Kittaka, A.; Laverny, G.; Rochel, N. 4-Hydroxy-1alpha,25-Dihydroxyvitamin D(3): Synthesis and Structure-Function Study. Biomolecules 2024, 14, 551. [Google Scholar] [CrossRef] [PubMed]
- Chatterjee, I.; Lu, R.; Zhang, Y.; Zhang, J.; Dai, Y.; Xia, Y.; Sun, J. Vitamin D receptor promotes healthy microbial metabolites and microbiome. Sci. Rep. 2020, 10, 7340. [Google Scholar] [CrossRef] [PubMed]
- Abe, K.; Ino, H.; Niwa, T.; Semmy, D.; Takaochi, A.; Nishimura, T.; Mogi, C.; Uenaka, M.; Ishii, M.; Tanaka, K.; et al. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Sci. Adv. 2024, 10, eadi1621. [Google Scholar] [CrossRef] [PubMed]
- Boughanem, H.; Ruiz-Limon, P.; Pilo, J.; Lisbona-Montanez, J.M.; Tinahones, F.J.; Moreno Indias, I.; Macias-Gonzalez, M. Linking serum vitamin D levels with gut microbiota after 1-year lifestyle intervention with Mediterranean diet in patients with obesity and metabolic syndrome: A nested cross-sectional and prospective study. Gut Microbes 2023, 15, 2249150. [Google Scholar] [CrossRef]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Sun, J. Bringing Vitamin D and the Vitamin D Receptor into the Limelight. Biomolecules 2024, 14, 1094. https://doi.org/10.3390/biom14091094
Sun J. Bringing Vitamin D and the Vitamin D Receptor into the Limelight. Biomolecules. 2024; 14(9):1094. https://doi.org/10.3390/biom14091094
Chicago/Turabian StyleSun, Jun. 2024. "Bringing Vitamin D and the Vitamin D Receptor into the Limelight" Biomolecules 14, no. 9: 1094. https://doi.org/10.3390/biom14091094