Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment—A Review

Round 1

Reviewer 1 Report

The article ''Distribution of Orchids with Different Rooting Systems in the Czech Republic'' is very interesting. I congrats the authors for the extensive research.

Author Response

The article ''Distribution of Orchids with Different Rooting Systems in the Czech Republic'' is very interesting. I congrats the authors on the extensive research.

Response: Thanks for the comment, orchids are very interesting from various points of view, photochemistry, pharmacology, botany.

Author Response File: Author Response.docx

Reviewer 2 Report

Mexican Plants and Derivatives Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment-A Review that was authorized by Geovanna N. Quiñonez-Bastidas and Andrés Navarrete is a well-organized, comprehensively described , and scientifically sound work.

However, the chemical structures of the mentioned compounds used in inflammatory and neuropathic pain treatment are not found in the current version of the review. I suggest that the authors add the chemical structures in the revised manuscript.

Author Response

Mexican Plants and Derivatives Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment-A Review that was authorized by Geovanna N. Quiñonez-Bastidas and Andrés Navarrete is a well-organized, comprehensively described, and scientifically sound work.

 

Response: Thanks for your comment.

However, the chemical structures of the mentioned compounds used in inflammatory and neuropathic pain treatment are not found in the current version of the review. I suggest that the authors add the chemical structures in the revised manuscript.

Response: We include a figure (Figure 1) with the chemical structures of those compounds with anti-inflammatory or antinociceptive/antineuropathic effects.

 

Author Response File: Author Response.docx

Reviewer 3 Report

The manuscript complies useful information regarding Mexican plants as alternative for inflammatory and neuropathic pain treatment.

I see some English language mistakes and therefore it can be published after a critical english language check.

Author Response

The manuscript complies useful information regarding Mexican plants as alternative for inflammatory and neuropathic pain treatment.

Response: Thanks for your comment.

I see some English language mistakes and therefore it can be published after a critical English language check.

Response: The English language was revised completely.  

Author Response File: Author Response.docx

Reviewer 4 Report

“Mexican Plants and Derivates Compounds as Alternative for Inflammatory and Neuropathic Pain Treatment-A Review”

The idea of the paper is very interesting, especially for the readers from other sides of the globe. 

I have the following suggestions or comments:

1. The Latin name of species should include the author (botanist) - subchapters: 14, 20, 21, 23, 24, 28, 32, 34.
2. The Latin name of species, genera, and families should be written in italic.
3. There is a lot of spelling mistakes in the Latin names of the plants. 
4. The Latin name of the family should be written in capital letters.
5. In Latin names, ssp or var should not be in italic. 
6. Chapter 2.14. should be Choisya, not Conyza.
7. Compositae is the old name of the Asteraceae family. The authors use them both.
8. Some names of the family are written in quotation marks. Why? They are official, botanical names.
9. For all plants should provide the family name. (2.29)
10. I disagree that Chamomilla and Rosmarinus are Mexican plants. Maybe they are used in traditional medicine, but they do not suit the article's idea and title. Both species are well known from the medicinal and phytochemical side, so it is not valid to introduce them here.
11. In every point where it is possible should be given the group of metabolites that mentioned compounds belonging to. (2.2; 2.3; 2.5; 2.20).
12. Quercitrin is the quercetin rhamnoside. Authors cannot write “other flavonoids” as other that quercetin glycosides. Tiliroside is flavonoid derivative. Page 5, line 197. 
13. I do not know what the idea for the sequence of the plant in the paper was, but Brickellia species should be next to each other. 2.11 and 2.26.
14. Rutin is the common name of rutoside and hyperin for hyperoside. Rutoside and hyperoside should be used. 
15. I do not believe that rutoside possesses antinociceptive activity or acting via the opioid receptor. It should be checked.
16. 2.15 Is any known compound of Mimosa albida root? 
17. 2.18 Methyl brevifolincarboxylate or methylbrevifolin carboxylate?
18. I am not sure (honestly, I do not believe) that catechins exhibit the anti-neuropathic effect. It should be checked at independent reference.
19. Line 431. Why it is lethal? What compound is responsible for that effect?
20. Ursolic acid is a commonly occurring compound in higher plants. Is any information about its neuropathic activity?
21. I do not believe that flavonoid compound kaempferitrin (dirhamnoside of kaempferol) possesses antidepressant, antispasmodic activity, or acting via the opioid receptor. It should be checked.
22. The order of the plant in the table should be the same as in the text. They should be grouped (all information and citation connected with one species together, one by one).
23. On pages 20 and 21 in the table information is lacking or some technical problems with the layout happened. 
24. Exostema caribaeum is not mentioned in the text only in the table. References 193 and 194 cited these species are missing in the text.
25. Scaphyglottis livida is mentioned only in the table.
26. Plant species with annotation (no effect) should be deleted from the table.
27. An impressive number of references. Authors should look through all of them once again. The whole list should be checked. Some of the references are missing in the text (153, 192, 193, 194). Two of them are cited only in the table (241, 242). No. 241 should be cited on page 5, too. 242 is about species not mentioned in the text.

Spelling mistakes and other errors are marked in yellow in the text.

Author Response

Dear Reviewer,

Thanks for your accurate comments. We revised the manuscript and incorporated all suggestions.

 

Point 1: The Latin name of species should include the author (botanist) - subchapters: 14, 20, 21, 23, 24, 28, 32, 34.

 

Response 1: Changes were added into the manuscript.

 

Point 2: The Latin name of species, genera, and families should be written in italic.

 

Response 2: Changes were added into the manuscript.

 

Point 3: There is a lot of spelling mistakes in the Latin names of the plants.

 

Response 3: We revised the Latin names and made the corrections.

 

Point 4: The Latin name of the family should be written in capital letters.

 

Response 4: The changes in Latin name of the family were included.

 

Point 5: In Latin names, ssp or var should not be in italic.

 

Response 5: We included the changes in the manuscript.

 

Point 6: Chapter 2.14. should be Choisya, not Conyza.

 

Response 6: We did the change (line 268)

 

Point 7: Compositae is the old name of the Asteraceae family. The authors use them both.

 

Response 7: We unify the Asteraceae family

 

Point 8: Some names of the family are written in quotation marks. Why? They are official, botanical names.

 

Response 8: We did the corrections (2.28“Verbenaceae” family, 2.33. “Meliaceae”), only the popular names are written in quotation marks. Family names were written without quotes and with capital letter on italic form.

 

Point 9: For all plants should provide the family name. (2.29)

 

Response 9: Asteraceae family was included in Pittocaulon genus. In addition, we revised all the text and other families were included in 2.1, 2.2., etc.

 

Point 10: I disagree that Chamomilla and Rosmarinus are Mexican plants. Maybe they are used in traditional medicine, but they do not suit the article's idea and title. Both species are well known from the medicinal and phytochemical side, so it is not valid to introduce them here.

 

Response 10: We agree with the suggestion. Both plants are commonly used in Mexican folk, were introduced many years ago in Mexico but they are not native’s plants. Hence, we delete Chamomilla and Rosmarinus sections.

 

Point 11: In every point where it is possible should be given the group of metabolites that mentioned compounds belonging to. (2.2; 2.3; 2.5; 2.20).

 

Response 11: We prefer to include a figure (Figure 1) with the chemical structures of the secondary metabolites for which have been demonstrated anti-inflammatory or antinociceptive/antineuropathic effects.

 

Point 12: Quercitrin is the quercetin rhamnoside. Authors cannot write “other flavonoids” as other that quercetin glycosides. Tiliroside is flavonoid derivative. Page 5, line 197.

 

Response 12: Some authors suggested that Kaempferol-3,7-O-dirhamnoside (kaempferitrin), Quercetin-3-pentosylhexoside, Kaempferol-3-pentosylhexoside, Quercetin-3-O-glucoside (isoquercitrin), Kaempferol-3-O-glucoside (astragalin), Quercetin-3-O-rhamnoside (quercitrin), Kaempferol-3-O-rhamnoside,  Kaempferol-3-O-(6-p-coumaroyl)-glucoside (tiliroside), Quercetin-3,7-O-dirhamnoside, Quercetin-3-O-rutinoside (rutin), Quercetin-3-pentoside, Quercetin-malonylhexoside are the responsible of the anxiolytic effect of Tilia var mexicana. These compounds were detected on methanol extract from three different regions in Mexico. We made the corrections.

 

Point 13: I do not know what the idea for the sequence of the plant in the paper was, but Brickellia species should be next to each other. 2.11 and 2.26.

 

Response 13: We realized the observations and made the corresponding changes in the manuscript

 

Point 14: Rutin is the common name of rutoside and hyperin for hyperoside. Rutoside and hyperoside should be used.

 

Response 14: We change the common names (line 260-261).

 

Point 15: I do not believe that rutoside possesses antinociceptive activity or acting via the opioid receptor. It should be checked.

 

Response 15: Authors demonstrate that organic extract of Conyza filaginoides induces antinociceptive effects, moreover, rutoside “rutin” decreased the nociceptive behavior in mice submitted to formalin test. The antinociceptive effect of rutoside was reverted by flumazenil, bicuculline, and naltrexone.

Ovalle-Magallanes B, Déciga-Campos M, Mata R. Antinociceptive and hypoglycaemic evaluation of Conyza filaginoides (D.C.) Hieron Asteraceae. J Pharm Pharmacol. 2015 Dec;67(12):1733-43. doi: 10.1111/jphp.12477. Epub 2015 Sep 26. PMID: 26408418.

 

Point 16: 2.15 Is any known compound of Mimosa albida root?

 

Response 16: Our knowledge there are not reports about the phytochemical composition of Mimosa albida root.

 

Point 17: 2.18 Methyl brevifolincarboxylate or methylbrevifolin carboxylate?

 

Response 17: Methyl brevifolincarboxylate is correct. Was changed in 2.17. Geranium bellum Rose (line 338).

 

Point 18: I am not sure (honestly, I do not believe) that catechins exhibit the anti-neuropathic effect. It should be checked at independent reference.

 

Response 18:

1- Quiñonez-Bastidas GN, Pineda-Farias JB, Flores-Murrieta FJ, Rodríguez-Silverio J, Reyes-García JG, Godínez-Chaparro B, Granados-Soto V, Rocha-González HI. Antinociceptive effect of (-)-epicatechin in inflammatory and neuropathic pain in rats. Behav Pharmacol. 2018 Apr;29(2 and 3-Spec Issue):270-279. doi: 10.1097/FBP.0000000000000320. PMID: 28590304.

 

2-Addepalli V, Suryavanshi SV. Catechin attenuates diabetic autonomic neuropathy in streptozotocin induced diabetic rats. Biomed Pharmacother. 2018 Dec;108:1517-1523. doi: 10.1016/j.biopha.2018.09.179. Epub 2018 Oct 9. PMID: 30372853.

 

3- Quiñonez-Bastidas GN, Cervantes-Durán C, Rocha-González HI, Murbartián J, Granados-Soto V. Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats. Life Sci. 2013 Oct 17;93(17):637-45. doi: 10.1016/j.lfs.2013.08.022. Epub 2013 Sep 6. PMID: 24012613.

 

Point 19: Line 431. Why it is lethal? What compound is responsible for that effect?

 

Response 19: In Meckes study, the antinociceptive activity of 14 extracts of medicinal plants was tested. They registered mortality with the hexane extracts of A. farnesiana, C. tepejilote, J. spicigera, S. angustifolia, the chloroform extracts of A. farnesiana, J. spicigera, the methanol extract of E. globulus and the acetone–water extract of H. glomeratum. However, the responsible compounds contained into the extracts was not clarified.

 

Point 20: Ursolic acid is a commonly occurring compound in higher plants. Is any information about its neuropathic activity?

 

Response 20: There is a report about anti-hyperalgesia induced by Ursolic acid in the neuropathic pain model. The proposal was included in 2.5 Agastache Mexicana.

Reference: Bhat RA, Lingaraju MC, Pathak NN, Kalra J, Kumar D, Kumar D, Tandan SK. Effect of ursolic acid in attenuating chronic constriction injury-induced neuropathic pain in rats. Fundam Clin Pharmacol. 2016 Dec;30(6):517–28.

 

 

Point 21: I do not believe that flavonoid compound kaempferitrin (dirhamnoside of kaempferol) possesses antidepressant, antispasmodic activity, or acting via the opioid receptor. It should be checked.

 

Response 21: Kaempferitrin (Km) isolated from the plant Justicia spicigera was evaluated in forced swimming and a suspension tail test in mice. Moreover, the author suggested that ani depressant effect induced by Km involved the serotoninergic pathway.

Reference: Cassani J, Dorantes-Barrón AM, Novales LM, Real GA, Estrada-Reyes R. Anti-depressant-like effect of kaempferitrin isolated from Justicia spicigera Schltdl (Acanthaceae) in two behavior models in mice: evidence for the involvement of the serotonergic system. Molecules. 2014 Dec 19;19(12):21442-61. doi: 10.3390/molecules191221442. PMID: 25532842; PMCID: PMC6271707.

 

Regarding antispasmodic effect:

Data suggested that administration of kaempferitrin reduces the number of writhes in a mice model. Moreover, the administration of ethanolic extract of Justicia spicigera, which contains Kaempferitrin, induces a regulatory effect on motility and a partial relaxing response on the intestinal tissue. In addition, an antinociceptive effect in a writing constriction model was observed. This antinociceptive effect was abolished by the serotonergic and opioidergic antagonists, suggesting the participation of these pathways.

 

Reference:

De Melo GO, Malvar Ddo C, Vanderlinde FA, Rocha FF, Pires PA, Costa EA, de Matos LG, Kaiser CR, Costa SS. Antinociceptive and anti-inflammatory kaempferol glycosides from Sedum dendroideum. J Ethnopharmacol. 2009 Jul 15;124(2):228-32. doi: 10.1016/j.jep.2009.04.024. Epub 2009 May 3. PMID: 19397977.

 

Aguirre-Hernández E, González-Trujano ME, Martínez AL, Moreno J, Kite G, Terrazas T, Soto-Hernández M. HPLC/MS analysis and anxiolytic-like effect of quercetin and kaempferol flavonoids from Tilia americana var. mexicana. J Ethnopharmacol. 2010 Jan 8;127(1):91-7. doi: 10.1016/j.jep.2009.09.044. Epub 2009 Sep 30. PMID: 19799990.

 

Point 22: The order of the plant in the table should be the same as in the text. They should be grouped (all information and citation connected with one species together, one by one).

 

Response 22 We did the changes in the table.

 

Point 23: On pages 20 and 21 in the table information is lacking or some technical problems with the layout happened.

 

Response 23: Corrections in the table were added.

 

Point 24: Exostema caribaeum is not mentioned in the text only in the table. References 193 and 194 cited these species are missing in the text.

 

Response 24: Exostema caribeum was eliminated in accordance with the point 25 and 26.

 

Point 25: Scaphyglottis livida is mentioned only in the table.

 

Response 25: We do not include Scaphyglottis livida, this plant doesn’t present an antinociceptive effect, also, there is only one report about its antinociceptive effects, which did not demonstrate. Because of this, we decided to delete all plants that do not have effects, according to your observation on point 26.

 

Point 26: We restructured the table, missing the plants with the legend “no effect”.

 

Response 26: Please provide your response for Point 2. (in red)

 

Point 27: An impressive number of references. Authors should look through all of them once again. The whole list should be checked. Some of the references are missing in the text (153, 192, 193, 194). Two of them are cited only in the table (241, 242). No. 241 should be cited on page 5, too. 242 is about species not mentioned in the text.

 

Response 27: References were revised and mentioned in tex. Some references were eliminated in accordance with deleted chapters Chamomilla and Rosmarinus.

 

Author Response File: Author Response.docx

Round 2

Reviewer 4 Report

Dear Author,

now the paper presents very good. I have atached pdf file with some speling mistakes marked.

Best regards

Comments for author File: Comments.pdf

Author Response

 

now the paper presents very good. I have atached pdf file with some speling mistakes marked.

Response: 

Many thanks to reviewer 4, for carefully reading our manuscript and finding the punctual typographical errors.

The corrections indicated by the reviewer were made 7 in the text and one in the table.