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Volume 11
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10.3390/plants11172286
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Communication

A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh

by
Jiumn-Yih Wu
1,†,
Hsiou-Yu Ding
2,†,
Tzi-Yuan Wang
3,†,
Min-Hui Hsu
4 and
Te-Sheng Chang
4,*
1
Department of Food Science, National Quemoy University, Kinmen County 892, Taiwan
2
Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, No. 60 Erh-Jen Rd., Sec. 1, Tainan 71710, Taiwan
3
Biodiversity Research Center, Academia Sinica, Taipei 11529, Taiwan
4
Department of Biological Sciences and Technology, National University of Tainan, Tainan 70005, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Plants 2022, 11(17), 2286; https://doi.org/10.3390/plants11172286
Submission received: 1 August 2022 / Revised: 27 August 2022 / Accepted: 31 August 2022 / Published: 1 September 2022
(This article belongs to the Special Issue Isolation and Analysis of Characteristic Compounds from Herbal and Plant Extracts 2.0)
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Abstract

Ha-Soo-Oh is a traditional Chinese medicine prepared from the roots of Polygonum multiflorum Thunb. The herb extract has been widely used in Asian countries as a tonic agent and nutritional supplement for centuries. To identify new bioactive compounds in Chinese herbs, the biotransformation-guided purification (BGP) process was applied to Ha-Soo-Oh with Bacillus megaterium tyrosinase (BmTYR) as a biocatalyst. The result showed that a major biotransformed compound could be purified using the BGP process with preparative high-performance liquid chromatography (HPLC), and it was confirmed as a new compound, 2,3,5,3′,4′-pentahydroxystilbene-2-O-β-glucoside (PSG) following mass and nucleic magnetic resonance (NMR) spectral analyses. PSG was further confirmed as a biotransformation product from 2,3,5,4′-tetrahydroxystilbene-2-O-β-glucoside (TSG) by BmTYR. The new PSG exhibited 4.7-fold higher 1,1-diphenyl-2-picrylhydrazine (DPPH) free radical scavenging activity than that of TSG. The present study highlights the potential usage of BGP in herbs to discover new bioactive compounds in the future.
Keywords: Polygonum multiflorum; Ha-Soo-Oh; tyrosinase; biotransformation; hydroxylation; melanogenesis; antioxidant Polygonum multiflorum; Ha-Soo-Oh; tyrosinase; biotransformation; hydroxylation; melanogenesis; antioxidant

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MDPI and ACS Style

Wu, J.-Y.; Ding, H.-Y.; Wang, T.-Y.; Hsu, M.-H.; Chang, T.-S. A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh. Plants 2022, 11, 2286. https://doi.org/10.3390/plants11172286

AMA Style

Wu J-Y, Ding H-Y, Wang T-Y, Hsu M-H, Chang T-S. A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh. Plants. 2022; 11(17):2286. https://doi.org/10.3390/plants11172286

Chicago/Turabian Style

Wu, Jiumn-Yih, Hsiou-Yu Ding, Tzi-Yuan Wang, Min-Hui Hsu, and Te-Sheng Chang. 2022. "A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh" Plants 11, no. 17: 2286. https://doi.org/10.3390/plants11172286

APA Style

Wu, J.-Y., Ding, H.-Y., Wang, T.-Y., Hsu, M.-H., & Chang, T.-S. (2022). A New Stilbene Glucoside from Biotransformation-Guided Purification of Chinese Herb Ha-Soo-Oh. Plants, 11(17), 2286. https://doi.org/10.3390/plants11172286

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