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Volume 11
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10.3390/plants11192540
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Article

Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis

by
Hwa Pyoung Lee
1,
Wooram Choi
1,
Ki Woong Kwon
1,
Long You
1,
Laily Rahmawati
1,
Van Dung Luong
2,
Wonhee Kim
3,
Byoung-Hee Lee
3,
Sarah Lee
3,
Ji Hye Kim
1,* and
Jae Youl Cho
1,*
1
Department of Integrative Biotechnology, Sungkyunkwan University, Suwon 16419, Korea
2
Department of Biology, Dalat University, 01 Phu Dong Thien Vuong, Dalat 670000, Vietnam
3
National Institute of Biological Resources, Environmental Research Complex, Incheon 222689, Korea
*
Authors to whom correspondence should be addressed.
Plants 2022, 11(19), 2540; https://doi.org/10.3390/plants11192540
Submission received: 4 September 2022 / Revised: 25 September 2022 / Accepted: 26 September 2022 / Published: 27 September 2022
(This article belongs to the Special Issue Biological Activities of Plant Extracts II)
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Abstract

Grewia tomentosa Juss. is a deciduous shrub that mainly grows in Asia. Despite studies of other Grewia species for treatment of various diseases, Grewia tomentosa Juss. has not been studied as a medicinal herb. This study evaluates the anti-allergic and anti-topic dermatitis activity of Grewia tomentosa Juss. ethanol extract (Gt-EE). The results show that Gt-EE suppressed IgE–antigen-induced β-hexosaminidase release. The mRNA expression of IL-1β, IL-4, IL-5, IL-6, IL-13, TNF-α, MCP-1, and TSLP, which are involved in allergic responses, was inhibited by Gt-EE in IgE-stimulated RBL-2H3 cells. In addition, the phosphorylation of Syk, PLCγ1, PKCδ, PI3K, AKT, NF-κB p65, NF-κB p50, p38, JNK, and ERK1/2 was decreased by Gt-EE in these cells. Gt-EE also showed anti-inflammatory effects in in vivo mouse models. In passive cutaneous anaphylaxis (PCA), a commonly used mouse model, Gt-EE decreased the allergic response, infiltration of mast cells, and mRNA level of IL-4. Furthermore, Gt-EE ameliorated symptoms of DNCB-induced atopic dermatitis (AD). In DNCB-induced AD, Gt-EE suppressed the increase in mast cells, serum IgE level, expression of allergic mediators (IL-1β, IL-4, IL-5, IL-6, TNF-α), and phosphorylation of proteins (IκBα, NF-κB p65, NF-κB p50, p38, JNK, and ERK1/2) implicated in allergic reactions
Keywords: Grewia tomentosa Juss.; allergic inflammation; mast cell; passive cutaneous anaphylaxis; atopic dermatitis Grewia tomentosa Juss.; allergic inflammation; mast cell; passive cutaneous anaphylaxis; atopic dermatitis

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MDPI and ACS Style

Lee, H.P.; Choi, W.; Kwon, K.W.; You, L.; Rahmawati, L.; Luong, V.D.; Kim, W.; Lee, B.-H.; Lee, S.; Kim, J.H.; et al. Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis. Plants 2022, 11, 2540. https://doi.org/10.3390/plants11192540

AMA Style

Lee HP, Choi W, Kwon KW, You L, Rahmawati L, Luong VD, Kim W, Lee B-H, Lee S, Kim JH, et al. Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis. Plants. 2022; 11(19):2540. https://doi.org/10.3390/plants11192540

Chicago/Turabian Style

Lee, Hwa Pyoung, Wooram Choi, Ki Woong Kwon, Long You, Laily Rahmawati, Van Dung Luong, Wonhee Kim, Byoung-Hee Lee, Sarah Lee, Ji Hye Kim, and et al. 2022. "Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis" Plants 11, no. 19: 2540. https://doi.org/10.3390/plants11192540

APA Style

Lee, H. P., Choi, W., Kwon, K. W., You, L., Rahmawati, L., Luong, V. D., Kim, W., Lee, B.-H., Lee, S., Kim, J. H., & Cho, J. Y. (2022). Inhibitory Effects of Grewia tomentosa Juss. on IgE-Mediated Allergic Reaction and DNCB-Induced Atopic Dermatitis. Plants, 11(19), 2540. https://doi.org/10.3390/plants11192540

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