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Review

Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components

by
Camila Castanho Cardinelli
1,
Josiane Elizabeth Almeida e Silva
2,3,
Rayssa Ribeiro
2,
Valdir F. Veiga-Junior
2,*,
Elisabete Pereira dos Santos
1 and
Zaida Maria Faria de Freitas
1,*
1
Department of Drugs and Medicines, Faculty of Pharmacy, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, Brazil
2
Department of Chemical Engineering, Military Institute of Engineering, Rio de Janeiro 22290-270, Brazil
3
Department of Biological Sciences, Institute of Biological Sciences, Federal University of Amazonas, Manaus 69080-900, Brazil
*
Authors to whom correspondence should be addressed.
Plants 2023, 12(5), 1054; https://doi.org/10.3390/plants12051054
Submission received: 9 January 2023 / Revised: 15 February 2023 / Accepted: 22 February 2023 / Published: 27 February 2023
(This article belongs to the Special Issue Medicinal Plants and Natural Products in South America)
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Abstract

Vegetable oils are among the most important traditional resources of Amazonia. Oleoresins are a type of oil that have interesting characteristics and highly bioactive properties with pharmacological potential. Oleoresins produced in the trunks of Copaifera (Fabaceae) spp. trees, known as copaiba oils, are made up of terpenes from the sesquiterpene (volatile) and diterpene (resinous) classes, but in amounts that vary between species and depending on several factors, such as soil type. Despite being used for medicinal purposes, via topical and oral application, the toxic effects of copaiba oils and their constituents are little known. The current paper reviews the toxicological studies, both in vitro and in vivo, described in the literature for copaiba oils, as well as the cytotoxic characteristics (against microorganisms and tumor cells) in in silico, in vitro and in vivo models for the sesquiterpenes and diterpenes that make up these oils.
Keywords: Copaifera; isolated compounds; toxicity; biological activity Copaifera; isolated compounds; toxicity; biological activity
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MDPI and ACS Style

Cardinelli, C.C.; Silva, J.E.A.e.; Ribeiro, R.; Veiga-Junior, V.F.; Santos, E.P.d.; de Freitas, Z.M.F. Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components. Plants 2023, 12, 1054. https://doi.org/10.3390/plants12051054

AMA Style

Cardinelli CC, Silva JEAe, Ribeiro R, Veiga-Junior VF, Santos EPd, de Freitas ZMF. Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components. Plants. 2023; 12(5):1054. https://doi.org/10.3390/plants12051054

Chicago/Turabian Style

Cardinelli, Camila Castanho, Josiane Elizabeth Almeida e Silva, Rayssa Ribeiro, Valdir F. Veiga-Junior, Elisabete Pereira dos Santos, and Zaida Maria Faria de Freitas. 2023. "Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components" Plants 12, no. 5: 1054. https://doi.org/10.3390/plants12051054

APA Style

Cardinelli, C. C., Silva, J. E. A. e., Ribeiro, R., Veiga-Junior, V. F., Santos, E. P. d., & de Freitas, Z. M. F. (2023). Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components. Plants, 12(5), 1054. https://doi.org/10.3390/plants12051054

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