Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway
Abstract
:1. Introduction
2. Results
2.1. Identification and Annotation of DDL SE and TGH Orthologs across the Tree of Life
2.2. Conservation of Domain Architecture in DDL SE and TGH Orthologs
2.3. Phylogenetic Classification of miRNA Biogenesis Factors
2.4. Functionally Divergent Residues Were Identified in the FHA Domain of Metazoan and Green Plant DDL Orthologs
3. Discussions
4. Conclusions
5. Materials and Methods
5.1. Homolog Mining Domain Architecture Analyses and Multiple Sequence Alignment
5.2. Phylogenetic Analyses and Estimation of Functional Divergence
5.3. miRNA Length Analysis
5.4. Deposition of the Phylogenetic Tree
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Type II Divergence | |
---|---|
αML | 0.753156 |
θII ± SE | 0.054996 ± 0.105161 |
GR/GC | 0.612903/0.387097 |
N/C/R | 101/24/38 |
F00, N/C/R | 0.331288/0.024540/0.012270 |
Residues (PP) | V21P (4.269792) |
P31V (4.269792) | |
K95G (4.269792) |
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Moturu, T.R.; Sinha, S.; Salava, H.; Thula, S.; Nodzyński, T.; Vařeková, R.S.; Friml, J.; Simon, S. Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway. Plants 2020, 9, 299. https://doi.org/10.3390/plants9030299
Moturu TR, Sinha S, Salava H, Thula S, Nodzyński T, Vařeková RS, Friml J, Simon S. Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway. Plants. 2020; 9(3):299. https://doi.org/10.3390/plants9030299
Chicago/Turabian StyleMoturu, Taraka Ramji, Sansrity Sinha, Hymavathi Salava, Sravankumar Thula, Tomasz Nodzyński, Radka Svobodová Vařeková, Jiří Friml, and Sibu Simon. 2020. "Molecular Evolution and Diversification of Proteins Involved in miRNA Maturation Pathway" Plants 9, no. 3: 299. https://doi.org/10.3390/plants9030299