Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis
Abstract
:1. Introduction
2. Results and Discussion
2.1. Therapeutic Effects of KM1608 on DSS-Induced Colitis in Mice
2.2. Biodistribution Analysis Using Optical Fluorescence Imaging
3. Materials and Methods
3.1. Preparation of KM1608
3.2. Animals
3.3. DSS-Induced Colitis in Mice
3.4. FDG-PET Imaging in Colitis-Induced Mice
3.5. Assessment of Inflammatory Mediators in the Colon of Colitis Mouse
3.6. High-Performance Liquid Chromatography (HPLC) Analysis
3.7. Dehydrocostus Lactone Biodistribution
3.8. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Lee, S.; Kim, S.-B.; Lee, J.; Park, J.; Choi, S.; Hwang, G.S.; Choi, H.-S.; Kang, K.S. Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis. Plants 2020, 9, 1175. https://doi.org/10.3390/plants9091175
Lee S, Kim S-B, Lee J, Park J, Choi S, Hwang GS, Choi H-S, Kang KS. Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis. Plants. 2020; 9(9):1175. https://doi.org/10.3390/plants9091175
Chicago/Turabian StyleLee, Sullim, Sang-Back Kim, Jaemin Lee, Jimin Park, Sungyoul Choi, Gwi Seo Hwang, Han-Seok Choi, and Ki Sung Kang. 2020. "Evaluation of Anti-Colitis Effect of KM1608 and Biodistribution of Dehydrocostus Lactone in Mice Using Bioimaging Analysis" Plants 9, no. 9: 1175. https://doi.org/10.3390/plants9091175