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Chemosensors
Volume 12
Issue 7
10.3390/chemosensors12070132
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

A Rapid and Interference-Resistant Formaldehyde Detection Method Based on Surface-Enhanced Raman Spectroscopy with A Reaction-Induced Self-Amplification Strategy

by
Chen Wang
1,
Yanli Gao
1,
Xinrong Qiu
1,
Lifang Nie
1,
Yang Liu
1,
Rigui Zhou
2,
Hongpeng Wang
3 and
Shengjun Xiong
1,*
1
HT-NOVA Co., Ltd., Beijing 101312, China
2
Research Center of Intelligent Information Processing and Quantum Intelligent Computing, College of Information Engineering, Shanghai Maritime University, Shanghai 201306, China
3
Key Laboratory of Space Active Opto-Electronics Technology, Chinese Academy of Sciences, Shanghai 200083, China
*
Author to whom correspondence should be addressed.
Chemosensors 2024, 12(7), 132; https://doi.org/10.3390/chemosensors12070132
Submission received: 24 April 2024 / Revised: 17 May 2024 / Accepted: 5 July 2024 / Published: 8 July 2024
(This article belongs to the Special Issue Advanced Spectroscopy Technology for Chemical Qualitative and Quantitative Analysis)
Versions Notes

Abstract

Formaldehyde is widely utilized across various industries such as food, textiles, and leather, yet its presence raises significant health concerns due to its irritation and carcinogenicity. Numerous methods have been developed to probe it in solution and gas states. Among them, absorption spectroscopy-based methods commonly employed. However, these methods require complex preprocessing for colored solutions to avoid interference. In response to this challenge, a novel interference-resistant detection kit leveraging surface-enhanced Raman spectroscopy (SERS) coupled with reaction-induced self-amplification for rapid and direct detection of formaldehyde was developed. The kit needed only ten minutes and achieved a limit of detection lower than 10−4 μg/mL with a handheld Raman spectrometer. Thanks to the kit’s reaction with formaldehyde, colloidal nanoparticles were linked to form “hot-spots” to further enhance the SERS signals. The signal demonstrated outstanding resistance to interference, including different dyes, ensuring a practical tool for direct detection of formaldehyde in complex solutions.
Keywords: surface-enhanced Raman spectroscopy; formaldehyde detection; interference-resistant detection; reaction-induced self-amplification strategy surface-enhanced Raman spectroscopy; formaldehyde detection; interference-resistant detection; reaction-induced self-amplification strategy

Share and Cite

MDPI and ACS Style

Wang, C.; Gao, Y.; Qiu, X.; Nie, L.; Liu, Y.; Zhou, R.; Wang, H.; Xiong, S. A Rapid and Interference-Resistant Formaldehyde Detection Method Based on Surface-Enhanced Raman Spectroscopy with A Reaction-Induced Self-Amplification Strategy. Chemosensors 2024, 12, 132. https://doi.org/10.3390/chemosensors12070132

AMA Style

Wang C, Gao Y, Qiu X, Nie L, Liu Y, Zhou R, Wang H, Xiong S. A Rapid and Interference-Resistant Formaldehyde Detection Method Based on Surface-Enhanced Raman Spectroscopy with A Reaction-Induced Self-Amplification Strategy. Chemosensors. 2024; 12(7):132. https://doi.org/10.3390/chemosensors12070132

Chicago/Turabian Style

Wang, Chen, Yanli Gao, Xinrong Qiu, Lifang Nie, Yang Liu, Rigui Zhou, Hongpeng Wang, and Shengjun Xiong. 2024. "A Rapid and Interference-Resistant Formaldehyde Detection Method Based on Surface-Enhanced Raman Spectroscopy with A Reaction-Induced Self-Amplification Strategy" Chemosensors 12, no. 7: 132. https://doi.org/10.3390/chemosensors12070132

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