Implication of Sphingolipid Metabolism Gene Dysregulation and Cardiac Sphingosine-1-Phosphate Accumulation in Heart Failure
, Ignacio José Sánchez-Lázaro 1,2,3, Manuel Portolés 1,2, Esther Roselló-Lletà 1,2,*,†and EstefanÃa Tarazón 1,2,*,†Round 1
Reviewer 1 Report
This manuscript demonstrates the potentially important role of sphingolipid metabolism in the pathogenesis of heart failure. The authors found accumulation of ceramide and sphingosine-1-phosphate in cardiac muscle tissue in patients with heart failure. The materials and methods of the study are adequate. The results of this study have fundamental and potential therapeutic significance.
The article is suitable for publication and I have only minor comments:
- Abstract: "S1P levels have not ever been measured in cardiac tissue" S1P - abbreviation is not defined in abstract.
- "cardiac muscle tissue" or "myocardium" instead of "cardiac tissue".
- In my opinion, it is necessary to add a figure/table summarizing the possible negative effects of sphingolipids (ceramide and S1P) on the myocardium.
Author Response
Please see the attachment.
Author Response File: 
Author Response.pdf
Reviewer 2 Report
This is generally a well-written and comprehensive article regarding the implication of sphingolipid metabolism gene dysregulation and cardiac sphingosine-1-phosphate accumulation in heart failure. The article is well-structured, very interesting and the results are presented in an appropriate manner, being clear and transparent. The set goals correspond to the conclusions. I consider that the study is valuable and sound and can be published in its current form.
Author Response
We appreciate the words of the Reviewer #2 and are grateful that he has considered our work suitable for publication in Biomedicines.
