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Article

The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation

by
Leonardo Fernandez-Avila
1,2,
Aribert Maryosly Castro-Amaya
2,
Andrea Molina-Pineda
3,4,
Rodolfo Hernández-Gutiérrez
3,
Luis Felipe Jave-Suarez
1,2,* and
Adriana Aguilar-Lemarroy
1,2,*
1
Programa de Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico
2
División de Inmunología, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Jalisco, Mexico
3
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C., Guadalajara 44270, Jalisco, Mexico
4
Consejo Nacional de Ciencia y Tecnología, CONAHCYT, Mexico City 03940, Mexico
*
Authors to whom correspondence should be addressed.
Biomedicines 2023, 11(10), 2655; https://doi.org/10.3390/biomedicines11102655
Submission received: 1 September 2023 / Revised: 20 September 2023 / Accepted: 22 September 2023 / Published: 28 September 2023
(This article belongs to the Special Issue The Role of Cytokines in Health and Disease)
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Abstract

Cervical cancer (CC) is a serious global health issue, and it is well-known that HPV infection is the main etiological factor that triggers carcinogenesis. In cancer, chemokine ligands and receptors are involved in tumor cell growth, metastasis, leukocyte infiltration, and angiogenesis; however, information on the role played by E6/E7 of HPV16/18 in the modulation of chemokines is very limited. Therefore, this study aimed to determine whether chemokines are differentially expressed in CC-derived cell lines; if E6/E7 oncoproteins from HPV16 and 18 are capable of mediating chemokine expression, what is the expression profile of chemokines in tissues derived from CC and what is their impact on the overall survival of patients with this pathology? For this purpose, RNA sequencing and real-time PCR were performed on SiHa, HeLa, and C33A tumorigenic cell lines, on the non-tumorigenic HaCaT cells, and the E6/E7 HPV-transduced HaCaT cell models. Furthermore, chemokine expression and survival analysis were executed on 304 CC and 22 normal tissue samples from The Cancer Genome Atlas (TCGA) repository. The results demonstrate that CXCL1, CXCL2, CXCL3, and CXCL8 are regulated by E6/E7 of HPV16 and 18, are overexpressed in CC biopsies, and that their higher expression is related to a worse prognostic survival.
Keywords: chemokines; HPV; E6; E7; cervical cancer; CXCL; prognosis marker; HaCaT cells; HeLa; SiHa; C33A chemokines; HPV; E6; E7; cervical cancer; CXCL; prognosis marker; HaCaT cells; HeLa; SiHa; C33A
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MDPI and ACS Style

Fernandez-Avila, L.; Castro-Amaya, A.M.; Molina-Pineda, A.; Hernández-Gutiérrez, R.; Jave-Suarez, L.F.; Aguilar-Lemarroy, A. The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation. Biomedicines 2023, 11, 2655. https://doi.org/10.3390/biomedicines11102655

AMA Style

Fernandez-Avila L, Castro-Amaya AM, Molina-Pineda A, Hernández-Gutiérrez R, Jave-Suarez LF, Aguilar-Lemarroy A. The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation. Biomedicines. 2023; 11(10):2655. https://doi.org/10.3390/biomedicines11102655

Chicago/Turabian Style

Fernandez-Avila, Leonardo, Aribert Maryosly Castro-Amaya, Andrea Molina-Pineda, Rodolfo Hernández-Gutiérrez, Luis Felipe Jave-Suarez, and Adriana Aguilar-Lemarroy. 2023. "The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation" Biomedicines 11, no. 10: 2655. https://doi.org/10.3390/biomedicines11102655

APA Style

Fernandez-Avila, L., Castro-Amaya, A. M., Molina-Pineda, A., Hernández-Gutiérrez, R., Jave-Suarez, L. F., & Aguilar-Lemarroy, A. (2023). The Value of CXCL1, CXCL2, CXCL3, and CXCL8 as Potential Prognosis Markers in Cervical Cancer: Evidence of E6/E7 from HPV16 and 18 in Chemokines Regulation. Biomedicines, 11(10), 2655. https://doi.org/10.3390/biomedicines11102655

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