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Biomedicines
Volume 11
Issue 6
10.3390/biomedicines11061579
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Review

Personalized Treatment of Glioblastoma: Current State and Future Perspective

by
Alen Rončević
1,2,*,
Nenad Koruga
1,2,
Anamarija Soldo Koruga
2,3,
Robert Rončević
2,4,
Tatjana Rotim
2,4,
Tihana Šimundić
2,5,
Domagoj Kretić
2,4,
Marija Perić
2,6,
Tajana Turk
2,4 and
Damir Štimac
2,7
1
Department of Neurosurgery, University Hospital Center Osijek, 31000 Osijek, Croatia
2
Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia
3
Department of Neurology, University Hospital Center Osijek, 31000 Osijek, Croatia
4
Department of Diagnostic and Interventional Radiology, University Hospital Center Osijek, 31000 Osijek, Croatia
5
Department of Nephrology, University Hospital Center Osijek, 31000 Osijek, Croatia
6
Department of Cytology, University Hospital Center Osijek, 31000 Osijek, Croatia
7
Department of Radiology, National Memorial Hospital Vukovar, 32000 Vukovar, Croatia
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(6), 1579; https://doi.org/10.3390/biomedicines11061579
Submission received: 14 March 2023 / Revised: 24 May 2023 / Accepted: 27 May 2023 / Published: 30 May 2023
(This article belongs to the Section Neurobiology and Clinical Neuroscience)
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Abstract

Glioblastoma (GBM) is the most aggressive glial tumor of the central nervous system. Despite intense scientific efforts, patients diagnosed with GBM and treated with the current standard of care have a median survival of only 15 months. Patients are initially treated by a neurosurgeon with the goal of maximal safe resection of the tumor. Obtaining tissue samples during surgery is indispensable for the diagnosis of GBM. Technological improvements, such as navigation systems and intraoperative monitoring, significantly advanced the possibility of safe gross tumor resection. Usually within six weeks after the surgery, concomitant radiotherapy and chemotherapy with temozolomide are initiated. However, current radiotherapy regimens are based on population-level studies and could also be improved. Implementing artificial intelligence in radiotherapy planning might be used to individualize treatment plans. Furthermore, detailed genetic and molecular markers of the tumor could provide patient-tailored immunochemotherapy. In this article, we review current standard of care and possibilities of personalizing these treatments. Additionally, we discuss novel individualized therapeutic options with encouraging results. Due to inherent heterogeneity of GBM, applying patient-tailored treatment could significantly prolong survival of these patients.
Keywords: glioblastoma; chemotherapy; immunotherapy; neurosurgery; radiotherapy glioblastoma; chemotherapy; immunotherapy; neurosurgery; radiotherapy

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MDPI and ACS Style

Rončević, A.; Koruga, N.; Soldo Koruga, A.; Rončević, R.; Rotim, T.; Šimundić, T.; Kretić, D.; Perić, M.; Turk, T.; Štimac, D. Personalized Treatment of Glioblastoma: Current State and Future Perspective. Biomedicines 2023, 11, 1579. https://doi.org/10.3390/biomedicines11061579

AMA Style

Rončević A, Koruga N, Soldo Koruga A, Rončević R, Rotim T, Šimundić T, Kretić D, Perić M, Turk T, Štimac D. Personalized Treatment of Glioblastoma: Current State and Future Perspective. Biomedicines. 2023; 11(6):1579. https://doi.org/10.3390/biomedicines11061579

Chicago/Turabian Style

Rončević, Alen, Nenad Koruga, Anamarija Soldo Koruga, Robert Rončević, Tatjana Rotim, Tihana Šimundić, Domagoj Kretić, Marija Perić, Tajana Turk, and Damir Štimac. 2023. "Personalized Treatment of Glioblastoma: Current State and Future Perspective" Biomedicines 11, no. 6: 1579. https://doi.org/10.3390/biomedicines11061579

APA Style

Rončević, A., Koruga, N., Soldo Koruga, A., Rončević, R., Rotim, T., Šimundić, T., Kretić, D., Perić, M., Turk, T., & Štimac, D. (2023). Personalized Treatment of Glioblastoma: Current State and Future Perspective. Biomedicines, 11(6), 1579. https://doi.org/10.3390/biomedicines11061579

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