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Biomedicines
Volume 11
Issue 8
10.3390/biomedicines11082141
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Article

Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia

by
Eun-Hye Park
1,
Jin-Moo Kim
1,
EunHwa Seong
1,
Eunmi Lee
1,
Kiyuk Chang
1,2 and
Young Choi
1,2,*
1
Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
2
Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
*
Author to whom correspondence should be addressed.
Biomedicines 2023, 11(8), 2141; https://doi.org/10.3390/biomedicines11082141
Submission received: 22 June 2023 / Revised: 27 July 2023 / Accepted: 28 July 2023 / Published: 29 July 2023
(This article belongs to the Special Issue Recent Advances in Ischemic Heart Diseases)
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Abstract

The scar border zone is a main source of reentry responsible for ischemic ventricular tachycardia (VT). We evaluated the effects of mesenchymal stem cell (MSC) injection into the scar border zone on arrhythmic risks in a post-myocardial infarction (MI) animal model. Rabbit MI models were generated by left descending coronary artery ligation. Surviving rabbits after 4 weeks underwent left thoracotomy and autologous MSCs or phosphate-buffered saline (PBS) was administered to scar border zones in two rabbits in each group. Another rabbit without MI underwent a sham procedure (control). An implantable loop recorder (ILR) was implanted in the left chest wall in all animals. Four weeks after cell injections, ventricular fibrillation was induced in 1/2 rabbit in the PBS group by electrophysiologic study, and no ventricular arrhythmia was induced in the MSC group or control. Spontaneous VT was not detected during ILR analysis in any animal for 4 weeks. Histologic examination showed restoration of connexin 43 (Cx43) expression in the MSC group, which was higher than in the PBS group and comparable to the control. In conclusion, MSC injections into the MI scar border zone did not increase the risk of VT and were associated with favorable Cx43 expression and arrangement.
Keywords: mesenchymal stem cells; ventricular tachycardia; myocardial infarction; connexin 43; ambulatory electrocardiographic monitoring mesenchymal stem cells; ventricular tachycardia; myocardial infarction; connexin 43; ambulatory electrocardiographic monitoring

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MDPI and ACS Style

Park, E.-H.; Kim, J.-M.; Seong, E.; Lee, E.; Chang, K.; Choi, Y. Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia. Biomedicines 2023, 11, 2141. https://doi.org/10.3390/biomedicines11082141

AMA Style

Park E-H, Kim J-M, Seong E, Lee E, Chang K, Choi Y. Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia. Biomedicines. 2023; 11(8):2141. https://doi.org/10.3390/biomedicines11082141

Chicago/Turabian Style

Park, Eun-Hye, Jin-Moo Kim, EunHwa Seong, Eunmi Lee, Kiyuk Chang, and Young Choi. 2023. "Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia" Biomedicines 11, no. 8: 2141. https://doi.org/10.3390/biomedicines11082141

APA Style

Park, E.-H., Kim, J.-M., Seong, E., Lee, E., Chang, K., & Choi, Y. (2023). Effects of Mesenchymal Stem Cell Injection into Healed Myocardial Infarction Scar Border Zone on the Risk of Ventricular Tachycardia. Biomedicines, 11(8), 2141. https://doi.org/10.3390/biomedicines11082141

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