Bioactive Steroids Bearing Oxirane Ring
Round 1
Reviewer 1 Report
It is an excellent article on the anticancer potential of cyclobutane-containing compounds. It will be great for audiences of medicinal chemistry and drug discovery, researcher. It is well-written as well presented with many excellent illustrations.
It is an excellent article on the anticancer potential of cyclobutane-containing compounds. It will be great for audiences of medicinal chemistry and drug discovery, researcher. It is well-written as well presented with many excellent illustrations.
Author Response
Thank you very much for reading my biomedicines-2538600 manuscript "Bioactive Steroids Bearing Oxirane Ring" submitted by Biomedicines. I'm glad you liked the article. I hope that readers of Biomedicines will also find this article interesting and useful.
Reviewer 2 Report
It is known that the use of the cyclobutane ring in natural compounds has become a promising direction in the search for new anticancer agents. The present reviewer explores a wide range of natural compounds containing the cyclobutane ring and highlights their potential as valuable candidates for cancer treatment. The review presents specific examples of cyclobutane-containing compounds known for their remarkable antitumor properties, revealing their unique structural characteristics and biological activity.
This is undoubtedly an interesting work that deserves the attention of readers. 1. However, it seems to me that in the tables for each compound it is necessary to provide a link to the literary source, which describes the given properties. 2. activities with Pa > 0.7 are shown, check for the abbreviation Pa when using it for the first time.
Author Response
Thank you very much for reading my biomedicines-2538600 manuscript "Bioactive Steroids Bearing Oxirane Ring" submitted by Biomedicines.
As for your proposal, I think that it is not advisable to do so, since the text contains links to articles that should not be duplicated. In addition, I made an addition (highlighted in blue) which describes that some activities were determined using the PASS program. I hope that my additions will satisfy your suggestions.
Thanks for the positive feedback on the article.
