Identification of Novel Tumor Pyroptosis-Related Antigens and Pyroptosis Subtypes for Developing mRNA Vaccines in Pancreatic Adenocarcinoma
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Collection and Preprocessing
2.2. cBioPortal Analysis and GEPIA Analysis
2.3. Tumor Antigens and Immune Cells Infiltration
2.4. Discovery and Validation of Pyroptosis Subtypes
2.5. Prognostic Evaluation of the Pyroptosis Subtypes
2.6. Weighted Gene Co-Expression Network Analysis (WGCNA)
2.7. Construction of Pyroptosis Landscape of Tumor Microenvironment
2.8. Statistical Analysis
3. Results
3.1. Identification of Potential Pyroptosis-Related Antigens in PAAD
3.2. Identification of Potential Pyroptosis Subtypes in PAAD
3.3. The Relationship between Pyroptosis Subtypes and Mutation Status
3.4. The Relationship between Pyroptosis Subtypes and Immunomodulator
3.5. The Molecular and Cellular Features of Pyroptosis Subtypes
3.6. Pyroptosis Landscape of PAAD
3.7. Identification of Pyroptosis Gene Co-Expression Modules and Hub Genes in PAAD
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Lin, Q.; Liang, L.; Wang, Q.; Wang, X.; You, Y.; Rong, Y.; Zhou, Y.; Guo, X. Identification of Novel Tumor Pyroptosis-Related Antigens and Pyroptosis Subtypes for Developing mRNA Vaccines in Pancreatic Adenocarcinoma. Biomedicines 2024, 12, 726. https://doi.org/10.3390/biomedicines12040726
Lin Q, Liang L, Wang Q, Wang X, You Y, Rong Y, Zhou Y, Guo X. Identification of Novel Tumor Pyroptosis-Related Antigens and Pyroptosis Subtypes for Developing mRNA Vaccines in Pancreatic Adenocarcinoma. Biomedicines. 2024; 12(4):726. https://doi.org/10.3390/biomedicines12040726
Chicago/Turabian StyleLin, Qiaowei, Li Liang, Qing Wang, Xiao Wang, Yang You, Yefei Rong, Yuhong Zhou, and Xi Guo. 2024. "Identification of Novel Tumor Pyroptosis-Related Antigens and Pyroptosis Subtypes for Developing mRNA Vaccines in Pancreatic Adenocarcinoma" Biomedicines 12, no. 4: 726. https://doi.org/10.3390/biomedicines12040726