Next Article in Journal
Lipid Toxicity in the Cardiovascular-Kidney-Metabolic Syndrome (CKMS)
Next Article in Special Issue
T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature
Previous Article in Journal
Correlation of Systemic Inflammation Parameters and Serum SLFN11 in Small Cell Lung Cancer—A Prospective Pilot Study
Previous Article in Special Issue
The Possible Role of Pathogens and Chronic Immune Stimulation in the Development of Diffuse Large B-Cell Lymphoma
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomedicines
Volume 12
Issue 5
10.3390/biomedicines12050977
biomedicines-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Beyond Chemotherapy: Present and Future Perspectives in the Treatment of Lymphoproliferative Disorders

by
Fulvio Massaro
*,
Fabio Andreozzi
,
Tom Abrassart
,
Julie Castiaux
,
Hanne Massa
,
Ornella Rizzo
and
Marie Vercruyssen
Hematology Department, Institut Jules Bordet, Université Libre de Bruxelles (ULB), 1000 Brussels, Belgium
*
Author to whom correspondence should be addressed.
Biomedicines 2024, 12(5), 977; https://doi.org/10.3390/biomedicines12050977
Submission received: 27 March 2024 / Revised: 17 April 2024 / Accepted: 23 April 2024 / Published: 29 April 2024
(This article belongs to the Special Issue Recent Advances in Lymphoma)
Browse Figure
Versions Notes

Abstract

Over the past three decades, the treatment of lymphoproliferative disorders has undergone profound changes, notably due to the increasing availability of innovative therapies with the potential to redefine clinical management paradigms. A major impact is related to the development of monoclonal antibodies, checkpoint inhibitors, bispecific antibodies, and chimeric antigen receptor T (CAR-T) cell therapies. This review discusses the current landscape of clinical trials targeting various hematological malignancies, highlighting promising early-phase results and strategies to overcome resistance. Lymphoproliferative disorders encompass a range of conditions: while in Hodgkin lymphoma (HL) the goal is to reduce chemotherapy-related toxicity by integrating immunotherapy into the frontline setting, peripheral T cell lymphoma (PTCL) lacks effective targeted therapies. The review emphasizes a shifting therapeutic landscape towards precision medicine and treatment modalities that are less toxic yet more effective.
Keywords: lymphoproliferative disorders; non-Hodgkin lymphoma (NHL); Hodgkin lymphoma (HL); immunotherapy; monoclonal antibodies; checkpoint inhibitors; bispecific antibodies; CAR-T cell lymphoproliferative disorders; non-Hodgkin lymphoma (NHL); Hodgkin lymphoma (HL); immunotherapy; monoclonal antibodies; checkpoint inhibitors; bispecific antibodies; CAR-T cell

Share and Cite

MDPI and ACS Style

Massaro, F.; Andreozzi, F.; Abrassart, T.; Castiaux, J.; Massa, H.; Rizzo, O.; Vercruyssen, M. Beyond Chemotherapy: Present and Future Perspectives in the Treatment of Lymphoproliferative Disorders. Biomedicines 2024, 12, 977. https://doi.org/10.3390/biomedicines12050977

AMA Style

Massaro F, Andreozzi F, Abrassart T, Castiaux J, Massa H, Rizzo O, Vercruyssen M. Beyond Chemotherapy: Present and Future Perspectives in the Treatment of Lymphoproliferative Disorders. Biomedicines. 2024; 12(5):977. https://doi.org/10.3390/biomedicines12050977

Chicago/Turabian Style

Massaro, Fulvio, Fabio Andreozzi, Tom Abrassart, Julie Castiaux, Hanne Massa, Ornella Rizzo, and Marie Vercruyssen. 2024. "Beyond Chemotherapy: Present and Future Perspectives in the Treatment of Lymphoproliferative Disorders" Biomedicines 12, no. 5: 977. https://doi.org/10.3390/biomedicines12050977

APA Style

Massaro, F., Andreozzi, F., Abrassart, T., Castiaux, J., Massa, H., Rizzo, O., & Vercruyssen, M. (2024). Beyond Chemotherapy: Present and Future Perspectives in the Treatment of Lymphoproliferative Disorders. Biomedicines, 12(5), 977. https://doi.org/10.3390/biomedicines12050977

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop