Abstract
Around 30–60% of patients with rheumatoid arthritis (RA) present treatment failure to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs). Chitinase-like proteins (CLPs) (YKL-40, YKL-39, SI-CLP) might play a role, as they are associated with the inflammatory process. This study aimed to evaluate CLP utility as a biomarker in the treatment failure of csDMARDs. A case–control study included 175 RA patients classified into two groups based on therapeutic response according to DAS28-ESR: responders (DAS28 < 3.2); non-responders (DAS28 ≥ 3.2). CLP serum levels were determined by ELISA. Multivariable logistic regression and receiver operating characteristic (ROC) curves were used to evaluate CLPs’ utility as biomarkers of treatment failure. Non-responders presented higher levels of YKL-40, YKL-39, and SI-CLP compared with responders (all: p < 0.001). YKL-40 correlated positively with YKL-39 (rho = 0.39, p < 0.001) and SI-CLP (rho = 0.23, p = 0.011) and YKL-39 with SI-CLP (rho = 0.34, p < 0.001). The addition of CLPs to the regression models improves diagnostic accuracy (AUC 0.918) compared to models including only clinical classical variables (AUC 0.806) p < 0.001. Non-responders were positive for all CLPs in 35.86%. Conclusions: CLPs could be considered as a useful biomarker to assess treatment failure, due to their association with clinical variables and improvement to the performance of regression models.
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MDPI and ACS Style
Esparza-Díaz, J.D.T.; Gamez-Nava, J.I.; Gonzalez-Lopez, L.; Saldaña-Cruz, A.M.; Machado-Sulbaran, A.C.; Beltrán-Ramírez, A.; Guillén-Medina, M.R.; Flores-Vargas, A.G.; Pérez-Guerrero, E.E.
Elevated Serum Levels of YKL-40, YKL-39, and SI-CLP in Patients with Treatment Failure to DMARDs in Patients with Rheumatoid Arthritis. Biomedicines 2024, 12, 1406.
https://doi.org/10.3390/biomedicines12071406
AMA Style
Esparza-Díaz JDT, Gamez-Nava JI, Gonzalez-Lopez L, Saldaña-Cruz AM, Machado-Sulbaran AC, Beltrán-Ramírez A, Guillén-Medina MR, Flores-Vargas AG, Pérez-Guerrero EE.
Elevated Serum Levels of YKL-40, YKL-39, and SI-CLP in Patients with Treatment Failure to DMARDs in Patients with Rheumatoid Arthritis. Biomedicines. 2024; 12(7):1406.
https://doi.org/10.3390/biomedicines12071406
Chicago/Turabian Style
Esparza-Díaz, José David Tadeo, Jorge Ivan Gamez-Nava, Laura Gonzalez-Lopez, Ana Miriam Saldaña-Cruz, Andrea Carolina Machado-Sulbaran, Alberto Beltrán-Ramírez, Miryam Rosario Guillén-Medina, Ana Gabriela Flores-Vargas, and Edsaúl Emilio Pérez-Guerrero.
2024. "Elevated Serum Levels of YKL-40, YKL-39, and SI-CLP in Patients with Treatment Failure to DMARDs in Patients with Rheumatoid Arthritis" Biomedicines 12, no. 7: 1406.
https://doi.org/10.3390/biomedicines12071406
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