A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse?
Abstract
:1. Introduction
1.1. Starting Point #1: Common Features of the Pathogenesis of Dementia, CKD, and IPF
1.1.1. Common Clinical Features
1.1.2. Pathology: Shrinkage and Fibrosis/Gliosis
1.1.3. All Three Are Highly Vascular
1.1.4. Low Resistance, High Pulsatility
1.1.5. Relation to Age: The Reassuring Normality of Lethal Disease
1.1.6. Hypertension Is a Risk Factor for All Three
1.1.7. Reserve Tissue, Clinical Threshold
1.1.8. Relentless Progression
1.1.9. The Pathology of Normal Ageing Is Also the Pathology of the Lethal Condition
1.2. Starting Point #2: Evidence of APICH in the Ageing Brain
2. Evidence That the Kidney and Lung Are Also Damaged by APICH
2.1. Kidney
2.2. Lung
3. What About the Liver? The Spleen? The Retina?
4. Summary and Implications; Therapeutic Opportunity
4.1. Implications
4.2. Conclusions
Funding
Conflicts of Interest
References
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Stone, J.; Robinson, S.R.; Mitrofanis, J.; Johnstone, D.M. A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse? Biomedicines 2024, 12, 1969. https://doi.org/10.3390/biomedicines12091969
Stone J, Robinson SR, Mitrofanis J, Johnstone DM. A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse? Biomedicines. 2024; 12(9):1969. https://doi.org/10.3390/biomedicines12091969
Chicago/Turabian StyleStone, Jonathan, Stephen R. Robinson, John Mitrofanis, and Daniel M. Johnstone. 2024. "A Triple Mystery of Insidious Organ Failure: Are the Lung, Kidney and Brain All Damaged by the Ageing Pulse?" Biomedicines 12, no. 9: 1969. https://doi.org/10.3390/biomedicines12091969