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Open AccessArticle
Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases
by
Daniel Ungureanu
Daniel Ungureanu 1,2,3
,
Adina Popa
Adina Popa 3,*
,
Adina Nemeș
Adina Nemeș 2,4,* and
Cătălina-Angela Crișan
Cătălina-Angela Crișan 5,6
1
Department Pharmacy I, Discipline of Pharmaceutical Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 41 Victor Babeș Street, 400012 Cluj-Napoca, Romania
2
“Prof. Dr. Ion Chiricuță” Oncology Institute, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania
3
Department Pharmacy II, Discipline of Clinical Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, 12 Ion Creangă Street, 400010 Cluj-Napoca, Romania
4
Department of Oncology, Discipline of Medical Oncology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania
5
Department of Neurosciences, Discipline of Psychiatry and Pediatric Psychiatry, “Iuliu Hațieganu” University of Medicine and Pharmacy, 43 Victor Babeș Street, 400012 Cluj-Napoca, Romania
6
First Psychiatric Clinic, Emergency County Hospital, 43 Victor Babeș Street, 400012 Cluj-Napoca, Romania
*
Authors to whom correspondence should be addressed.
Biomedicines 2024, 12(9), 1971; https://doi.org/10.3390/biomedicines12091971 (registering DOI)
Submission received: 12 July 2024
/
Revised: 26 August 2024
/
Accepted: 29 August 2024
/
Published: 1 September 2024
Abstract
Prostate cancer (PC) represents the second most common diagnosed cancer in men. The burden of diagnosis and long-term treatment may frequently cause psychiatric disorders in patients, particularly depression. The most common PC treatment option is androgen deprivation therapy (ADT), which may be associated with taxane chemotherapy. In patients with both PC and psychiatric disorders, polypharmacy is frequently present, which increases the risk of drug–drug interactions (DDIs) and drug-related adverse effects. Therefore, this study aimed to conduct a pharmacoepidemiologic study of the concomitant administration of PC drugs and psychotropics using three drug interaction databases (Lexicomp®, drugs.com®, and Medscape®). This study assayed 4320 drug–drug combinations (DDCs) and identified 814 DDIs, out of which 405 (49.63%) were pharmacokinetic (PK) interactions and 411 (50.37%) were pharmacodynamic (PD) interactions. The most common PK interactions were based on CYP3A4 induction (n = 275, 67.90%), while the most common PD interactions were based on additive torsadogenicity (n = 391, 95.13%). Proposed measures for managing the identified DDIs included dose adjustments, drug substitutions, supplementary agents, parameters monitoring, or simply the avoidance of a given DDC. A significant heterogenicity was observed between the selected drug interaction databases, which can be mitigated by cross-referencing multiple databases in clinical practice.
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MDPI and ACS Style
Ungureanu, D.; Popa, A.; Nemeș, A.; Crișan, C.-A.
Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases. Biomedicines 2024, 12, 1971.
https://doi.org/10.3390/biomedicines12091971
AMA Style
Ungureanu D, Popa A, Nemeș A, Crișan C-A.
Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases. Biomedicines. 2024; 12(9):1971.
https://doi.org/10.3390/biomedicines12091971
Chicago/Turabian Style
Ungureanu, Daniel, Adina Popa, Adina Nemeș, and Cătălina-Angela Crișan.
2024. "Concomitant Administration of Psychotropic and Prostate Cancer Drugs: A Pharmacoepidemiologic Study Using Drug–Drug Interaction Databases" Biomedicines 12, no. 9: 1971.
https://doi.org/10.3390/biomedicines12091971
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