Association between Vitamin D Status and Health Status of Adults in Western Libya

Round 1

Reviewer 1 Report (Previous Reviewer 3)

The authors have responded to my corrections , so the decision is approved for publishing 

Author Response

Manuscript title "Association between Vitamin D Status and Health Status of Adults in Western Libya”

 Comments and Suggestions for Authors

1. The authors have responded to my corrections, so the decision is approved for publishing

Author response

Thank you so much

Author Response File: Author Response.docx

Reviewer 2 Report (New Reviewer)

This study mainly focuses on the relationship between VitD status 22 and health status in Western Libya. This study is well designed. However, some issues need to be resolved before accepted. 

1. All the figures need to be remade, as these are so small and hard to be followed.

2. The Statistics should be descripted in detail. What methods are used for parametric and non-parametric test？

3. What is the limitation of the study? That should be well discussed.

Author Response

Manuscript title "Association between Vitamin D Status and Health Status of Adults in Western Libya”

 Comments and Suggestions for Authors

This study mainly focuses on the relationship between VitD status 22 and health status in Western Libya. This study is well designed. However, some issues need to be resolved before accepted.

1. All the figures need to be remade, as these are so small and hard to be followed.

Author response

• The figures have been remade to be clearer.

2. The Statistics should be descripted in detail. What methods are used for parametric and non-parametric test？

Author response

• In the methodology section, the statistics section has been rewritten.

3. What is the limitation of the study? That should be well discussed

Author response

• The limitation of this study has been discussed in many sections of the discussion.

Author Response File: Author Response.docx

Round 2

Reviewer 2 Report (New Reviewer)

This paper can be accepted in the present form.

This manuscript is a resubmission of an earlier submission. The following is a list of the peer review reports and author responses from that submission.

Round 1

Reviewer 1 Report

Simple summary should be re-written, improve the English

Introduction; badly written

Figure 1 and Figure 2: badly design with high error bars, what are the significance among treatments?

Table 1: add significance values among treatments (rows)

Reviewer 2 Report

Although of interest, the manuscript is bad written and not clear. Please re-write it, and good luck with a new submission. 

Reviewer 3 Report

All corrections should be done before start of publication process

There is no recommendations

Discussion needs more improvement and should be based upon discussing the obtained results with those of the previous investigators results

LN/22-34----is this highlights or what ??? the same like an ordinary abstract ( should be removed)

LN/35---add target instead of cross-sectional

LN/50---delete status after vitamin D

LN/50---add western Libya , epidemiological study and malnutrion to the keywords

LN/67-68---what is your opinion about vitD deficiency----leads to decrease parathyroid hormones and increase the insulin resistance---diabetes ---explain with reference

LN/68---cytokines like TNF ----and what else ????

LN/69---glucose hemostasis----how you can adjust it ????  

Are the following items have any relationship in the development of vitamin D deficiency disturbances or not ????

-Urbanization        -Demographic shifts

-Decreased outdoor activity                  -Air pollution

-Decrease cutaneous production of vitamin D with the age

Is the bariatric surgery has a role in the improvement vitamin D status or not ???

There is no plan for the studying area

There is no reference for the statistical analysis

LN/141----females are more prone to VitD deficiency than males ---why ?? Hormonal or tendency or what ?????

The most used methodology without references

LN/227---why did VitD deficiency is more health-related in Libyan adults than in young adults ????

LN/271-280----there is no references

LN/362---selected Cohort of male---explain

There is no recommendations

The most cited references contained more than 6 authors ---why ???? should be 6 at the maximum plus etal with the last ones ---APPLY FOR ALL

The most cited references need to be more update

Ref(1)---delete volume and pp and write like :-3:154-196/2007

Why you did not apply your obtained results experimentally on rats or mice for more confirmation ???

LN/454----there is no issue , number, volume or pages ---why ??