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Processes, Volume 6, Issue 9

2018 September - 38 articles

Cover Story: Despite a booming Synthetic Biology community and some notable successes, engineering biomolecular circuits with quantitatively predictable behavior remains extremely time-consuming. Mathematical models are uniquely suited to address this problem. Synthetic Biology has so far made limited use of mathematical models, mostly because inferring them is perceived as expensive and/or difficult. For Synthetic Biology to progress, model inference must be simpler, faster and ultimately cheaper. In this issue, we propose an iterative in-vivo Optimal Experimental Design approach that fully automates model calibration. We compare it with current model identification methods for biological parts and we show how this can lead to a reliable model much faster. View this paper.
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Articles (38)

  • Feature Paper
  • Review
  • Open Access
82 Citations
12,627 Views
27 Pages

Modeling Permeation through Mixed-Matrix Membranes: A Review

  • Gloria M. Monsalve-Bravo and
  • Suresh K. Bhatia

18 September 2018

Over the past three decades, mixed-matrix membranes (MMMs), comprising an inorganic filler phase embedded in a polymer matrix, have emerged as a promising alternative to overcome limitations of conventional polymer and inorganic membranes. However, w...

  • Article
  • Open Access
13 Citations
6,096 Views
25 Pages

17 September 2018

Owing to the pollution free nature, higher efficiency and noise free operation, fuel cells have been identified as ideal energy sources for the future. To avoid direct storage of hydrogen due to safety considerations, storing hydrocarbon fuel such as...

  • Article
  • Open Access
28 Citations
6,432 Views
22 Pages

Influence of Organic Ligands on the Colloidal Stability and Removal of ZnO Nanoparticles from Synthetic Waters by Coagulation

  • Rizwan Khan,
  • Muhammad Ali Inam,
  • Du Ri Park,
  • Saba Zam Zam,
  • Sookyo Shin,
  • Sarfaraz Khan,
  • Muhammad Akram and
  • Ick Tae Yeom

17 September 2018

The large-scale production and usage of zinc oxide nanoparticles (ZnO NPs) may lead to their post-release into the aquatic environment. In this study, the effect of hydrophobic/hydrophilic organic ligands on sorption and sedimentation of ZnO NPs has...

  • Article
  • Open Access
16 Citations
4,879 Views
26 Pages

17 September 2018

Transversely isotropic rocks are commonly encountered in rock engineering practices, and their strength and failure behavior is often governed by the property of anisotropy. The particle flow modeling method was utilized to investigate the failure me...

  • Article
  • Open Access
7 Citations
7,351 Views
19 Pages

Towards an Aspect-Oriented Design and Modelling Framework for Synthetic Biology

  • Philipp Boeing,
  • Miriam Leon,
  • Darren N. Nesbeth,
  • Anthony Finkelstein and
  • Chris P. Barnes

15 September 2018

Work on synthetic biology has largely used a component-based metaphor for system construction. While this paradigm has been successful for the construction of numerous systems, the incorporation of contextual design issues—either compositional,...

  • Article
  • Open Access
35 Citations
6,003 Views
18 Pages

15 September 2018

The widespread raising of swine in farms becomes a serious problem in terms of the emission of carbon dioxide (CO2) and methane (CH4). This study aims to measure concentrations of carbon dioxide and methane, which account for the largest percentage o...

  • Feature Paper
  • Article
  • Open Access
45 Citations
7,553 Views
18 Pages

Basic Dye Removal with Sorption onto Low-Cost Natural Textile Fibers

  • George Z. Kyzas,
  • Evi Christodoulou and
  • Dimitrios N. Bikiaris

14 September 2018

Over the last several years, the trend of researchers has been to use some very low-cost materials as adsorbents. For this purpose, some already commercially used bast fibers were selected as potential adsorbent materials to remove basic dye from syn...

  • Feature Paper
  • Review
  • Open Access
83 Citations
9,534 Views
20 Pages

Recent Advance on Draw Solutes Development in Forward Osmosis

  • Qingwu Long,
  • Yongmei Jia,
  • Jinping Li,
  • Jiawei Yang,
  • Fangmei Liu,
  • Jian Zheng and
  • Biao Yu

13 September 2018

In recent years, membrane technologies have been developed to address water shortage and energy crisis. Forward osmosis (FO), as an emerging membrane-based water treatment technology, employs an extremely concentrated draw solution (DS) to draw water...

  • Feature Paper
  • Article
  • Open Access
5 Citations
5,301 Views
20 Pages

11 September 2018

In this contribution, we aim to show that opinion dynamics and population balance modeling can benefit from an exchange of problems and methods. To support this claim, the Deffuant-Weisbuch model, a classical approach in opinion dynamics, is formulat...

  • Article
  • Open Access
23 Citations
8,603 Views
10 Pages

7 September 2018

The article summarizes a systematic process design for the extraction and purification of artemisinin from annual mugwort (Artemisia annua L.). Artemisinin serves as an anti-malaria drug, therefore, resource-efficient and economic processes for its p...

  • Feature Paper
  • Review
  • Open Access
121 Citations
14,351 Views
27 Pages

Photocatalytic Membranes in Photocatalytic Membrane Reactors

  • Pietro Argurio,
  • Enrica Fontananova,
  • Raffaele Molinari and
  • Enrico Drioli

7 September 2018

The present work gives a critical overview of the recent progresses and new perspectives in the field of photocatalytic membranes (PMs) in photocatalytic membrane reactors (PMRs), thus highlighting the main advantages and the still existing limitatio...

  • Article
  • Open Access
11 Citations
6,426 Views
35 Pages

7 September 2018

Solar energy is becoming a promising source of heat and power for electrical generation and desalination plants. In this work, an integrated study of modeling, optimization, and experimental work is undertaken for a parabolic trough concentrator comb...

  • Feature Paper
  • Article
  • Open Access
5 Citations
6,859 Views
13 Pages

6 September 2018

In recent papers we have discussed the use of cuboid packed-bed devices as alternative to columns for chromatographic separations. These devices address some of the major flow distribution challenges faced by preparative columns used for process-scal...

  • Article
  • Open Access
13 Citations
4,449 Views
18 Pages

Temporal Mixing Behavior of Conservative Solute Transport through 2D Self-Affine Fractures

  • Zhi Dou,
  • Brent Sleep,
  • Pulin Mondal,
  • Qiaona Guo,
  • Jingou Wang and
  • Zhifang Zhou

5 September 2018

In this work, the influence of the Hurst exponent and Peclet number (Pe) on the temporal mixing behavior of a conservative solute in the self-affine fractures with variable-aperture fracture and constant-aperture distributions were investigated. The...

  • Article
  • Open Access
17 Citations
14,214 Views
17 Pages

The Seepage Control of the Tunnel Excavated in High-Pressure Water Condition Using Multiple Times Grouting Method

  • Bin Gong,
  • Yujing Jiang,
  • Keisuke Okatsu,
  • Xuezhen Wu,
  • Jin Teduka and
  • Koichi Aoki

5 September 2018

Groundwater can cause many hazardous problems when a tunnel is excavating. Seepage force acting on the support structure and the tunnel surface cannot be negligible. Under high groundwater table condition, the seepage situation becomes more complex a...

  • Article
  • Open Access
9 Citations
5,849 Views
16 Pages

5 September 2018

The Effectiveness-Number of Transfer Unit method (ε-NTU method) was applied to determine the overall mass transfer coefficient, KLa, of operating gas-liquid absorbers treating Volatile Organic Compounds (VOCs). This method requires the knowle...

  • Feature Paper
  • Article
  • Open Access
11 Citations
8,651 Views
29 Pages

Mathematical Modeling of RBC Count Dynamics after Blood Loss

  • Manuel Tetschke,
  • Patrick Lilienthal,
  • Torben Pottgiesser,
  • Thomas Fischer,
  • Enrico Schalk and
  • Sebastian Sager

5 September 2018

The regeneration of red blood cells (RBCs) after blood loss is an individual complex process. We present a novel simple compartment model which is able to capture the most important features and can be personalized using parameter estimation. We comp...

  • Article
  • Open Access
11 Citations
4,521 Views
14 Pages

4 September 2018

The adsorptive properties of poly(1-methylpyrrol-2-ylsquaraine) (PMPS) particles were investigated in batch and column adsorption experiments as alternative adsorbent for the treatment of endocrine-disrupting chemicals in water. The PMPS particles we...

  • Article
  • Open Access
14 Citations
5,643 Views
18 Pages

Supported Ionic Liquid Membranes for Separation of Lignin Aqueous Solutions

  • Ricardo Abejón,
  • Javier Rabadán,
  • Silvia Lanza,
  • Azucena Abejón,
  • Aurora Garea and
  • Angel Irabien

1 September 2018

Lignin valorization is a key aspect to design sustainable management systems for lignocellulosic biomass. The successful implementation of bio-refineries requires high value added applications for the chemicals derived from lignin. Without effective...

  • Feature Paper
  • Review
  • Open Access
23 Citations
5,901 Views
14 Pages

1 September 2018

The fluid dynamics of macroscopic and microscopic systems is well developed and has been extensively validated. Its extraordinary success makes it tempting to apply Navier–Stokes fluid dynamics without modification to systems of ever decreasing...

  • Article
  • Open Access
14 Citations
6,546 Views
36 Pages

1 September 2018

Since modeling and simulation are the two most effective tools that can be used in the design or analysis process, they play a vital role in developing such system. In many cases, they are the only possible means of making a safe engineering decision...

  • Article
  • Open Access
32 Citations
6,033 Views
20 Pages

1 September 2018

Coal and gas outbursts are serious safety concerns in the Chinese coal industry. Mining of the upper or lower protective coal seams has been widely used to minimize this problem. This paper presents new findings from longwall mining-induced fractures...

  • Feature Paper
  • Review
  • Open Access
38 Citations
9,640 Views
19 Pages

1 September 2018

Pulsed field gradient (PFG) nuclear magnetic resonance (NMR) allows recording of molecular diffusion paths (notably, the probability distribution of molecular displacements over typically micrometers, covered during an observation time of typically m...

  • Feature Paper
  • Article
  • Open Access
22 Citations
8,094 Views
15 Pages

On-Line Optimal Input Design Increases the Efficiency and Accuracy of the Modelling of an Inducible Synthetic Promoter

  • Lucia Bandiera,
  • Zhaozheng Hou,
  • Varun B. Kothamachu,
  • Eva Balsa-Canto,
  • Peter S. Swain and
  • Filippo Menolascina

1 September 2018

Synthetic biology seeks to design biological parts and circuits that implement new functions in cells. Major accomplishments have been reported in this field, yet predicting a priori the in vivo behaviour of synthetic gene circuits is major a challen...

  • Article
  • Open Access
19 Citations
4,735 Views
14 Pages

1 September 2018

The existence of surface roughness, various contact conditions and the occurrence of flow nonlinearity make the flow process in natural rock fractures more complicated. To evaluate the fluid flow regimes in deformable rough-walled rock fractures, a g...

  • Article
  • Open Access
25 Citations
5,099 Views
18 Pages

1 September 2018

When the hard and thick key strata are located above the working face, the bed separation structure is easy to be formed after mining because of the high strength and integrity of the hard and thick key strata and the initial breaking step is large....

  • Feature Paper
  • Article
  • Open Access
17 Citations
4,790 Views
12 Pages

Dopamine Incorporated Forward Osmosis Membranes with High Structural Stability and Chlorine Resistance

  • Yi Wang,
  • Zhendong Fang,
  • Chaoxin Xie,
  • Shuaifei Zhao,
  • Derrick Ng and
  • Zongli Xie

1 September 2018

The degradation and detachment of the polyamide (PA) layer for the conventional thin-film composite (TFC) membranes due to chemical disinfectants cleaning with chlorine and material difference of PA layer and substrate are two major bottlenecks of fo...

  • Article
  • Open Access
12 Citations
4,829 Views
13 Pages

Shear-Flow Coupled Behavior of Artificial Joints with Sawtooth Asperities

  • Cheng Zhao,
  • Rui Zhang,
  • Qingzhao Zhang,
  • Zhenming Shi and
  • Songbo Yu

1 September 2018

The coupling between hydraulic and mechanical processes in rock joints has significantly influenced the properties and applications of rock mass in many engineering fields. In this study, a series of regular shear tests and shear-flow coupled tests w...

  • Article
  • Open Access
30 Citations
7,600 Views
17 Pages

Energy and Exergy Analysis of the S-CO2 Brayton Cycle Coupled with Bottoming Cycles

  • Muhammad Ehtisham Siddiqui,
  • Aqeel Ahmad Taimoor and
  • Khalid H. Almitani

1 September 2018

Supercritical carbon dioxide (S-CO2) Brayton cycles (BC) are soon to be a competitive and environment friendly power generation technology. Progressive technological developments in turbo-machineries and heat exchangers have boosted the idea of using...

  • Feature Paper
  • Article
  • Open Access
19 Citations
6,189 Views
25 Pages

1 September 2018

An experimental study in industry was previously carried out on a batch fluid bed granulation system by varying the inlet fluidizing air temperature, binder liquid spray atomization pressure, the binder liquid spray rate and the disintegrant composit...

  • Article
  • Open Access
17 Citations
4,827 Views
16 Pages

Simulation and Analysis of Oleic Acid Pretreatment for Microwave-Assisted Biodiesel Production

  • Weiquan Ma,
  • Tao Hong,
  • Tian Xie,
  • Fengxia Wang,
  • Bin Luo,
  • Jie Zhou,
  • Yang Yang,
  • Huacheng Zhu and
  • Kama Huang

28 August 2018

Oleic acid needs to be heated when it is utilized for biodiesel production, but, as a low-loss solution, oleic acid is difficult to heat by microwave. An efficient heating method for oleic acid is designed. A high loss material porous media is placed...

  • Article
  • Open Access
2 Citations
4,382 Views
18 Pages

27 August 2018

Regulatory T cells (Tregs) have an important role in self-tolerance. Understanding the functions of Tregs is important for preventing or slowing the progress of Type 1 Diabetes. We use a two-dimensional (2D) agent-based model to simulate immune respo...

  • Article
  • Open Access
7 Citations
4,402 Views
16 Pages

Photocatalytic Inactivation of Enterobacter cloacae and Escherichia coli Using Titanium Dioxide Supported on Two Substrates

  • Yelitza Aguas,
  • Margarita Hincapié,
  • Camilo Sánchez,
  • Liliana Botero and
  • Pilar Fernández-Ibañez

23 August 2018

The antibacterial photocatalytic activity of TiO2 supported over two types of substrates, borosilicate glass tubes (TiO2/SiO2-borosilicate glass tubes (BGT)) and low-density polyethylene pellets (TiO2-LDPE pellets), which were placed in a compound pa...

  • Feature Paper
  • Review
  • Open Access
7 Citations
4,946 Views
19 Pages

23 August 2018

Severe influenza infections are often characterized as having unique host responses (e.g., early, severe hypercytokinemia). Neuraminidase inhibitors can be effective in controlling the severe symptoms of influenza but are often not administered until...

  • Feature Paper
  • Article
  • Open Access
53 Citations
10,058 Views
21 Pages

Valorization of Shale Gas Condensate to Liquid Hydrocarbons through Catalytic Dehydrogenation and Oligomerization

  • Taufik Ridha,
  • Yiru Li,
  • Emre Gençer,
  • Jeffrey J. Siirola,
  • Jeffrey T. Miller,
  • Fabio H. Ribeiro and
  • Rakesh Agrawal

23 August 2018

The recent shale gas boom has transformed the energy landscape of the United States. Compared to natural gas, shale resources contain a substantial amount of condensate and natural gas liquids (NGLs). Many shale basin regions located in remote areas...

  • Article
  • Open Access
37 Citations
7,248 Views
11 Pages

23 August 2018

The oil industry is plagued with regular incidences of spills into the environment, causing environmental damage to flora and fauna, especially in marine environments where spills easily travel long distances from their sources. This study was carrie...

  • Feature Paper
  • Article
  • Open Access
13 Citations
4,560 Views
24 Pages

22 August 2018

Inference of biochemical network models from experimental data is a crucial problem in systems and synthetic biology that includes parameter calibration but also identification of unknown interactions. Stochastic modelling from single-cell data is kn...

  • Feature Paper
  • Article
  • Open Access
41 Citations
5,451 Views
22 Pages

21 August 2018

To reduce CO 2 emissions from power plants, electricity companies have diversified their generation sources. Fossil fuels, however, still remain an integral energy generation source as they are more reliable compared to the renewable energy so...

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Processes - ISSN 2227-9717