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Inorganics
Volume 11
Issue 5
10.3390/inorganics11050185
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Review

Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity

by
Raúl Colorado-Peralta
1,
José Luis Olivares-Romero
2,
Sharon Rosete-Luna
1,
Oscar García-Barradas
3,
Viviana Reyes-Márquez
4,
Delia Hernández-Romero
1,* and
David Morales-Morales
5,*
1
Facultad de Ciencias Químicas, Universidad Veracruzana, Prolongación de Oriente 6, No. 1009, Orizaba C.P. 94340, Veracruz, Mexico
2
Instituto de Ecología A.C., Red de Estudios Moleculares Avanzados, Clúster Científico y Tecnológico BioMimic®, Carretera Antigua a Coatepec, No. 351, Xalapa C.P. 91070, Veracruz, Mexico
3
Instituto de Química Aplicada, Universidad Veracruzana, Luis Castelazo Ayala S/N, Xalapa C.P. 91190, Veracruz, Mexico
4
Departamento de Ciencias Químico-Biológicas, Universidad de Sonora, Luis Encinas y Rosales S/N, Hermosillo C.P. 83000, Sonora, Mexico
5
Instituto de Química, Universidad Nacional Autónoma de México, Cd. Universitaria, Circuito Exterior S/N, Coyoacán C.P. 04510, Ciudad de México, Mexico
*
Authors to whom correspondence should be addressed.
Inorganics 2023, 11(5), 185; https://doi.org/10.3390/inorganics11050185
Submission received: 7 April 2023 / Revised: 18 April 2023 / Accepted: 19 April 2023 / Published: 25 April 2023
(This article belongs to the Special Issue Editorial Board Members’ Collection Series in “Featuring Ligands and Their Applications in Coordination Chemistry”)
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Abstract

Throughout human history, bacteria and fungi have caused infections that are difficult to combat. For this reason, countless research groups have developed novel compounds to solve this problem. Thiazole and benzothiazole are present in different structures with interesting biological effects and are used to develop new effective antimicrobial agents. Moreover, nitrogen atoms that are present in this heterocycle allow for coordination with various metals, forming metal complexes that enhance the biological activity of organic ligands that are often used as commercial drugs. This bibliographical review summarizes the copper complexes that use thiazole and benzothiazole as ligands and that report efficient antimicrobial activity against different bacteria and fungi.
Keywords: thiazole; benzothiazole; copper complexes; heterocycles; azoles; antibacterial; antifungal thiazole; benzothiazole; copper complexes; heterocycles; azoles; antibacterial; antifungal
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MDPI and ACS Style

Colorado-Peralta, R.; Olivares-Romero, J.L.; Rosete-Luna, S.; García-Barradas, O.; Reyes-Márquez, V.; Hernández-Romero, D.; Morales-Morales, D. Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity. Inorganics 2023, 11, 185. https://doi.org/10.3390/inorganics11050185

AMA Style

Colorado-Peralta R, Olivares-Romero JL, Rosete-Luna S, García-Barradas O, Reyes-Márquez V, Hernández-Romero D, Morales-Morales D. Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity. Inorganics. 2023; 11(5):185. https://doi.org/10.3390/inorganics11050185

Chicago/Turabian Style

Colorado-Peralta, Raúl, José Luis Olivares-Romero, Sharon Rosete-Luna, Oscar García-Barradas, Viviana Reyes-Márquez, Delia Hernández-Romero, and David Morales-Morales. 2023. "Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity" Inorganics 11, no. 5: 185. https://doi.org/10.3390/inorganics11050185

APA Style

Colorado-Peralta, R., Olivares-Romero, J. L., Rosete-Luna, S., García-Barradas, O., Reyes-Márquez, V., Hernández-Romero, D., & Morales-Morales, D. (2023). Copper-Coordinated Thiazoles and Benzothiazoles: A Perfect Alliance in the Search for Compounds with Antibacterial and Antifungal Activity. Inorganics, 11(5), 185. https://doi.org/10.3390/inorganics11050185

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