Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review
Abstract
:1. Introduction
2. Methodology
3. Role of DDT in Female Infertility
3.1. In Vitro Studies
3.2. Epidemiological Studies
3.2.1. DDT and Menstrual Cycle Length
3.2.2. DDT and Infertility/Fecundability
3.2.3. DDT and Preterm Birth
3.2.4. DDT and Fetal Loss
4. Role of DDT in Female Reproductive Cancers
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
Abbreviations
AR | Androgen Receptor |
cAMP | Cyclic Adenosine 3′, 5′-monophosphate |
CP | Clinical Pregnancy |
Cx | Connexin |
DDD | Dichlorodiphenyldichloroethane |
DDE | Dichlorodiphenyldichloroethylene |
DDT | Dichlorodiphenyltrichloroethane |
E2 | Estradiol |
EDC | Endocrine-disrupting Chemicals |
EPL | Early Pregnancy Loss |
ER | Estrogen Receptor |
Erβ | Estrogen Receptor Beta |
FSH | Follicle Stimulating Hormone |
hCG | Human chorionic gonadotropin |
hCG/LHR | Human chorionic gonadotropin/Luteinizing Hormone Receptor |
LRAT | Long-Range Atmospheric Transport |
LEH | Luminal Epithelial Height |
LH | Luteinizing Hormone |
LIF | Leukemia Inhibitor Factor |
NP-I | Neurophysin-1 |
ο,p′-DDD | ortho, para′-Dichlorodiphenyldichloroethane |
ο,p′-DDE | ortho, para′-Dichlorodiphenyldichloroethylene |
ο,p′-DDT | ortho, para′-Dichlorodiphenyltrichloroethane |
OCP | Organochlorine Pesticide |
OCP | Organochlorine Pesticide |
OT | Oxytocin |
p,p′-DDE | para, para′-Dichlorodiphenyldichloroethylene |
p,p′-DDT | para, para′-Dichlorodiphenyltrichloroethane |
p,p′-DDD | para, para′-Dichlorodiphenyldichloroethane |
P4 | Progesterone |
PGA | Prostaglandin A |
PGE2 | Prostaglandin E2 |
PGF2α | Prostaglandin F2 alpha |
LOG | Length of gestation |
POP | Persistent Organic Pollutant |
PRISMA | Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
PTB | Preterm Birth |
ROS | Reactive Oxygen Species |
SGA | Small for Gestational Age |
TTP | Time to Pregnancy |
UWW | Uterine Wet Weight |
References
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Chemical/Hormone | DDT Isomer | Levels of Chemical/Hormone |
---|---|---|
Estradiol | ο,p′-DDT | Increase or Decrease |
ο,p′-DDE | Increase or Decrease | |
ο,p′-DDD | Increase or Decrease | |
p,p′-DDT | Increase | |
p,p′-DDE | Increase | |
Oxytocin | DDT | Increase |
DDE | Increase | |
Prostaglandin A | DDT | Decrease |
DDE | Decrease | |
Prostaglandin F2a | DDT | Increase |
DDE | Increase | |
Prostaglandin E | DDT | Decrease |
DDE | Decrease | |
Progesterone | DDE | Increase |
hCG/LHR | p,p′-DDT | Decrease |
Sr No. | Study Type | Ethnicity | Population | Metabolite | Parameter | Effect |
---|---|---|---|---|---|---|
1 | Case–control | American | 289 | p,p′-DDT, p,p′-DDE | TTP | Decreased |
2 | Case–control | Mexican | 233 | p,p′-DDE | PTB | Increased |
3 | Nested case–control | American | 720 | DDT/DDE | Infertility | No statistically significant association |
4 | Case–control | North Indian | 100 | DDT/DDE | PTB | Increased |
5 | Case–control | Indian | 90 | p,p′-DDE | PTB | Increased |
6 | Case–control | Indian | 90 | p,p′-DDT, p,p′-DDE | PTB | Increased |
7 | Cohort | American | 2613 | DDT/DDE | Fetal loss | DDE increased, no relation with DDT |
8 | Cohort | American | 20,754 | DDT/DDE | PTB | No statistically significant association |
9 | Cohort | Chinese | 287 | o,p′-DDT, o,p′-DDE | Menstrual cycle length | Increased |
10 | Cohort | American | 1752 | p,p′-DDT, o,p′-DDT, p,p′-DDE | POG | Decreased |
11 | Prospective | Chinese | 291 | DDT | Clinical pregnancy | Decreased |
12 | Cohort | Bolivian | 200 | p,p′-DDE, o,p′-DDT | POG | Decreased |
13 | Prospective | Chinese | 388 | DDT | Fetal loss | Increased |
14 | Cross-sectional | Chinese | 466 | p,p′-DDE/DDT | Menstrual cycle length | Reduced age at menarche |
15 | Cross-sectional | Latina | 402 | p,p′-DDT, o,p′-DDT, p,p′-DDE | TTP | No statistically significant association |
16 | Pilot | Chinese | 60 | p,p′-DDT, o,p′-DDT | Menstrual cycle length | No statistically significant association |
17 | Pilot | German | 89 | DDT | Infertility | Increased |
18 | Pilot | Laotian | 50 | DDT/DDE | Menstrual cycle length | Decreased |
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Syed, S.; Qasim, S.; Ejaz, M.; Sammar; Khan, N.; Ali, H.; Zaker, H.; Hatzidaki, E.; Mamoulakis, C.; Tsatsakis, A.; et al. Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review. Toxics 2023, 11, 725. https://doi.org/10.3390/toxics11090725
Syed S, Qasim S, Ejaz M, Sammar, Khan N, Ali H, Zaker H, Hatzidaki E, Mamoulakis C, Tsatsakis A, et al. Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review. Toxics. 2023; 11(9):725. https://doi.org/10.3390/toxics11090725
Chicago/Turabian StyleSyed, Shermeen, Shandana Qasim, Maheen Ejaz, Sammar, Nimra Khan, Haider Ali, Himasadat Zaker, Eleftheria Hatzidaki, Charalampos Mamoulakis, Aristidis Tsatsakis, and et al. 2023. "Effects of Dichlorodiphenyltrichloroethane on the Female Reproductive Tract Leading to Infertility and Cancer: Systematic Search and Review" Toxics 11, no. 9: 725. https://doi.org/10.3390/toxics11090725