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Stability of Fly Maggot Peptides and Its Alleviating Effect on Lipopolysaccharide Combined with Hemocoagulase Oxidative Stress in Arbor Acres Chicks
by
,
Qin Wang
†,
Pingfei Qiu
†,
Zeru Peng
,
Junlong Wu
,
Ruiying Bao
,
Liangmin Huang
,
Xiaochun Li
,
Huiyu Shi
,
Haiwen Zhang
and
Xuemei Wang
* Animal Nutrition, Reproduction and Breeding Laboratory, Department of Animal ScienceSchool of Agricultural and Rural Affairs Hainan University, Danzhou, 571737, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Vet. Sci. 2024, 11(10), 470; https://doi.org/10.3390/vetsci11100470 (registering DOI)
Submission received: 31 August 2024
/
Revised: 26 September 2024
/
Accepted: 27 September 2024
/
Published: 1 October 2024
(This article belongs to the Topic Animal Diseases in Agricultural Production Systems, 2nd Edition)
Simple Summary
Considering the issue of antibiotic residues, developing equivalent alternatives in the context of banning antibiotics is key. Peptides are considered a satisfactory option, and the current study aims to demonstrate the effect of prophylactic fly maggot peptides on oxidative stress. Oral administration of fly maggot polypeptide can improve the oxidative stress induced by lipopolysaccharide combined with hemocoagulase, and improve the growth performance, antioxidant function, immune function, and intestinal barrier function of broilers.
Abstract
Recently, there has been fast-growing interest among researchers in discovering bioactive peptides from insects and evaluating their potential applications in livestock production. The present study aimed to assess the antioxidant properties and stability of fly maggot peptide (FMP) and its effects on Arbor Acres (AA) broilers' oxidative stress induced by lipopolysaccharide (LPS) and hemocoagulase (HC). A total of 108 one-day-old AA broilers were randomly divided into six groups: CG (normal saline, basal diet), DG (LPS + HC, basal diet), VG (DG + vitamin C 50 ug/kg), LPG (DG + FMP 5 mg/kg), MPG (DG + FMP 15 mg/kg), and HPG (DG + FMP 25 mg/kg). The results showed that the addition of FMP to the diet promoted LPS+ HC-induced increases in average daily gain (ADG), total superoxide dismutase (T-SOD), total antioxidant capacity (T-AOC). Meanwhile, FMP regulated the intestinal morphology. Additionally, FMP decreased the increase in the contents of malondialdehyde (MDA), the relative weight of immune organs, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). In conclusion, this research suggested that the addition of FMP can relieve the LPS+ HC-induced oxidative stress of AA broilers and the recommended dose of FMP is 25 mg/kg. This study presents a theoretical foundation for the addition of an FMP supplement for the purpose of protecting broilers’ growth.
