Effect of Leukoreduction by Pre-Storage Filtration on Coagulation Activity of Canine Plasma Collected for Transfusion
Abstract
:1. Introduction
2. Materials and Methods
2.1. Blood Donors, Sample Collection and Processing
2.2. Laboratory Analysis
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter (Reference Range) | Time | Non-Leuko-Reduced (Non-LR) Plasma | Leuko-Reduced (LR) Plasma | ||||||
---|---|---|---|---|---|---|---|---|---|
Min | Max | Median | 25th–75th Percentiles | Min | Max | Median | 25th–75th Percentiles | ||
PT (7–9.8 s) | D0 | 7.3 | 7.7 | 7.4 | 7.3–7.4 | 7.3 | 8.0 | 7.5 | 7.4–7.9 |
D7 | 7.1 | 7.7 | 7.6 | 7.3–7.7 | 7.2 | 8.5 | 7.6 | 7.3–8.2 | |
aPPT (11–16.9 s) | D0 | 14.1 | 15.7 | 14.7 | 14.1–15.3 | 18.6 | 21.8 | 20.2 | 19.6–21.0 |
D7 | 14.2 | 16.2 | 15.2 | 14.8–15.5 | 18.6 | 21.8 | 20.6 | 20.1–21.6 | |
FV (50–150%) | D0 | 80.0 | 99.0 | 86.0 | 83.7–96.0 | 65.0 | 101.0 | 80.0 | 72.5–90.5 |
D7 | 77.0 | 107.0 | 105.0 | 80.7–106.2 | 69.0 | 104.0 | 88.0 | 72.7–96.5 | |
FVIII (50–150%) | D0 | 76.0 | 131.0 | 109.0 | 90.2–121.2 | 64.0 | 95.0 | 93.0 | 84.2–94.2 |
D7 | 69.0 | 130.0 | 118.0 | 86.2–127.0 | 63.0 | 101.0 | 95.0 | 86.2–97.2 | |
FX (80–175%) | D0 | 82.0 | 109.0 | 103.0 | 85.0–106.0 | 82.0 | 100.0 | 91.0 | 85.7–93.2 |
D7 | 78.0 | 97.0 | 89.0 | 81.0–94.0 | 73.0 | 94.0 | 81.0 | 76.7–88.0 | |
FXI (50–150%) | D0 | 88.0 | 108.0 | 104.0 | 97.7–105.7 | 27.0 | 32.0 | 31.0 | 29.2–32.0 |
D7 | 109.0 | 138.0 | 119.0 | 113.5–131.2 | 33.0 | 48.0 | 41.0 | 39.0–43.5 | |
ATIII (95–140%) | D0 | 114.0 | 130.0 | 120.0 | 117.0–127.0 | 110.0 | 132.0 | 120.0 | 112.2–128.2 |
D7 | 108.0 | 130.0 | 120.0 | 111.7–126.2 | 106.0 | 136.0 | 114.0 | 109.0–128.5 | |
Fibrinogen (100–400 mg/mL) | D0 | 141.8 | 198.6 | 174.6 | 157.3–188.0 | 108.5 | 193.7 | 162.3 | 123.9–191.2 |
D7 | 150.7 | 284.2 | 255.3 | 197.5–283.4 | 204.6 | 336.1 | 250.8 | 205.8–313.7 | |
vWF (70–180%) | D0 | 50.0 | 105.0 | 91.0 | 58.2–96.0 | 27.0 | 89.0 | 80.0 | 63.7–83.7 |
D7 | 46.0 | 102.0 | 68.0 | 56.5–82.5 | 26.0 | 86.0 | 80.0 | 62.7–83.0 | |
D-dimers (0.01–0.35 μg/mL) | D0 | 0.16 | 0.45 | 0.23 | 0.16–0.43 | 0.02 | 0.14 | 0.10 | 0.06–0.12 |
D7 | 0.14 | 0.42 | 0.41 | 0.20–0.41 | 0.02 | 0.13 | 0.07 | 0.02–0.12 |
Variable (Reference Range) | Time Point | Non-Leuko-Reduced (Non-LR) Plasma Units | Leuko-Reduced (LR) Plasma Units | p-Value for Comparison Non-LR and LR Plasma Units | ||||||
---|---|---|---|---|---|---|---|---|---|---|
Median | Average Rank | Paired Difference D0 vs. D7 | Median | Average Rank | Paired Difference D0 vs. D7 | |||||
Median | p-Value | Median | p-Value | |||||||
PT (7–9.8 s) | D0 | 7.4 | 4.2 | 0.0 | - | 7.5 | 6.8 | 0.10 | 0.4375 | 0.1666 |
D7 | 7.6 | 5.0 | 7.6 | 6.0 | 0.5982 | |||||
aPTT (11–16.9 s) | D0 | 14.7 | 3.0 | 0.5 | 0.1250 | 20.2 | 8.0 | 0.4 | - | 0.0088 |
D7 | 15.2 | 3.0 | 20.6 | 8.0 | 0.0088 | |||||
FV (50–150%) | D0 | 86.0 | 6.3 | 8.0 | 0.3125 | 80.0 | 4.7 | 4.0 | 0.3125 | 0.4020 |
D7 | 105.0 | 6.8 | 88.0 | 4.2 | 0.1745 | |||||
FVIII (50–150%) | D0 | 109.0 | 7.1 | −1.0 | 0.8125 | 93.0 | 3.9 | 1.0 | 0.1875 | 0.0937 |
D7 | 118.0 | 6.4 | 95.0 | 4.6 | 0.3472 | |||||
FX (80–175%) | D0 | 103.0 | 6.3 | −8.0 | 0.0625 | 91.0 | 4.7 | −9.0 | 0.0625 | 0.4005 |
D7 | 89.0 | 6.5 | 81.0 | 4.5 | 0.2948 | |||||
FXI (50–150%) | D0 | 104.0 | 8.0 | 21.0 | 0.0625 | 31.0 | 3.0 | 9.0 | 0.0625 | 0.0088 |
D7 | 119.0 | 8.0 | 41.0 | 3.0 | 0.0088 | |||||
ATIII (95–140%) | D0 | 120.0 | 5.7 | −1.0 | - | 120.0 | 5.3 | −3.0 | 0.3125 | 0.8340 |
D7 | 120.0 | 5.6 | 114.0 | 5.4 | 0.9168 | |||||
Fibrinogen (100–400 mg/dl) | D0 | 174.6 | 6.2 | 80.7 | 0.125 | 162.3 | 4.8 | 97.8 | 0.0625 | 0.4647 |
D7 | 255.3 | 5.2 | 250.8 | 5.8 | 0.7540 | |||||
vWF (70–180%) | D0 | 91.0 | 6.4 | −4.0 | 0.0625 | 80.0 | 4.6 | −1.0 | - | 0.3472 |
D7 | 68.0 | 5.0 | 80.0 | 6.0 | 0.6015 | |||||
D-Dimers (0.01–0.35 μg/mL) | D0 | 0.23 | 7.00 | −0.01 | 0.8125 | 0.10 | 2.50 | −0.01 | - | 0.0139 |
D7 | 0.41 | 7.00 | 0.07 | 2.50 | 0.0139 |
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Spada, E.; Perego, R.; Baggiani, L.; Proverbio, D. Effect of Leukoreduction by Pre-Storage Filtration on Coagulation Activity of Canine Plasma Collected for Transfusion. Vet. Sci. 2021, 8, 157. https://doi.org/10.3390/vetsci8080157
Spada E, Perego R, Baggiani L, Proverbio D. Effect of Leukoreduction by Pre-Storage Filtration on Coagulation Activity of Canine Plasma Collected for Transfusion. Veterinary Sciences. 2021; 8(8):157. https://doi.org/10.3390/vetsci8080157
Chicago/Turabian StyleSpada, Eva, Roberta Perego, Luciana Baggiani, and Daniela Proverbio. 2021. "Effect of Leukoreduction by Pre-Storage Filtration on Coagulation Activity of Canine Plasma Collected for Transfusion" Veterinary Sciences 8, no. 8: 157. https://doi.org/10.3390/vetsci8080157