Cardiorespiratory Effects of Three Infusion Doses of Adenosine in Conscious Goats: A Preliminary Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals
2.2. Study Design
2.2.1. Cardiorespiratory Parameters and Rectal Temperature
2.2.2. Echocardiographic Parameters
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameters | Group | Time Points (Minutes) | |||||
---|---|---|---|---|---|---|---|
B | dInf | 1 | 3 | 5 | 10 | ||
HR (beats/min) | SAL | 108.3 ± 5.2 | 98.1 ±14.2 | 91.5 ± 10.5 | 98.5 ± 10.4 | 109 ± 11.6 | 100.5 ± 12.5 |
AD 50 | 108.7 ± 6.8 | 98.1 ± 6.8 | 101.8 ± 11.6 | 99.3 ± 9.1 | 102.3 ± 11 | 93.1 ± 6.9 | |
AD 100 | 103.3 ± 6 | 113.7 ± 4.2 | 94.6 ± 9.1 | 97.3 ± 9.9 | 99.6 ± 10.3 | 96.5 ± 13 | |
p = 0.001 ٭ | |||||||
AD 200 | 105.3 ± 8.6 | 131 ± 7.1 ٭ | 121.8 ± 6.4 ٭ | 106 ± 7 | 102 ± 7.8 | 105.2 ± 12.2 | |
p = 0.006 | p = 0.035 | ||||||
RR (breaths/min) | SAL | 20.1 ± 3.7 | 21.5 ± 2.8 | 21 ± 5.8 | 22 ± 5.1 | 22.5 ± 4 | 21.3 ± 3.5 |
AD 50 | 23.8 ± 3 | 22.6 ± 4.1 | 20 ± 3.2 | 21.6 ± 2.9 | 22.5 ± 4.4 | 21.3 ± 5.2 | |
AD 100 | 23 ± 5 | 22.1 ± 3.6 | 20.1 ± 2 | 20.6 ± 4.2 | 22.8 ± 4.9 | 23.8 ± 2 | |
AD 200 | 22.5 ± 3.3 | 41.1 ± 3٭ | 22.8 ± 3 | 21 ± 3 | 20.5 ± 3.5 | 23.3 ± 3 | |
p < 0.001 | |||||||
SpO2 (%) | SAL | 94.8 ± 3 | 93.8 ± 2.2 | 94 ± 2 | 93.5 ± 2.5 | 93.6 ± 2 | 94 ± 2.6 |
AD 50 | 95.2 ± 3 | 94 ± 2 | 93.8 ± 2.9 | 94 ± 2.8 | 94 ± 2.6 | 94.6 ± 2.6 | |
AD 100 | 95.1 ± 3.2 | 95.3 ± 3 | 94.6 ± 3.6 | 95 ± 2.9 | 94.6 ± 3.5 | 94.5 ± 3.4 | |
AD 200 | 95.2 ± 2.9 | 94.8 ± 2.4 | 95.3 ± 2.8 | 95 ± 3.4 | 94.2 ± 2.5 | 94.1 ± 1.6 | |
RT (°C) | SAL | 39.4 ± 0.16 | 39.5 ± 0.29 | 39.5 ± 0.19 | 39.5 ± 0.17 | 39.5 ± 0.24 | 39.15 ± 0.19 |
AD 50 | 39.4 ± 0.23 | 39.5 ± 0.21 | 39.5 ± 0.27 | 39.4 ± 0.23 | 39.5 ± 0.13 | 39.5 ± 0.10 | |
AD 100 | 39.4 ± 0.22 | 39.4 ± 0.24 | 39.5 ± 0.15 | 39.4 ± 0.27 | 39.4 ± 0.14 | 39.6 ± 0.12 | |
AD 200 | 39.5 ± 0.24 | 39.4 ± 0.17 | 39.5 ± 0.24 | 39.4 ± 0.30 | 39.5 ± 0.21 | 39.6 ± 0.20 |
Parameters | Group | Time Points (Minutes) | |||||
---|---|---|---|---|---|---|---|
B | dInf | 1 | 3 | 5 | 10 | ||
EF (%) | SAL | 72.1 ± 5.9 | 71.8 ± 4.2 | 72.6 ± 5.7 | 71.6 ± 4.8 | 75.5 ± 4.4 | 74.5 ± 4 |
AD 50 | 71.5 ± 2.8 | 72.8 ± 2.4 | 72.1 ± 4.8 | 71.8 ± 3.4 | 73 ± 2.9 | 73.5 ± 3 | |
AD 100 | 73 ± 4 | 74 ± 3.8 | 74.3 ± 3.3 | 73.5 ± 3.2 | 72.8 ± 4.7 | 72.5 ± 3.7 | |
AD 200 | 72.8 ± 2.7 | 75 ± 3.3 | 73.6 ± 4.2 | 73 ± 4.1 | 72.8 ± 4.4 | 73.8 ± 3.9 | |
FS (%) | SAL | 38.5 ± 3 | 39.3 ± 3.2 | 37.3 ± 4.6 | 38.3 ± 3.5 | 36.5 ± 2.5 | 38.1 ± 4 |
AD 50 | 38.3 ± 2.7 | 37.6 ± 2.2 | 37.3 ± 2.7 | 36.6 ± 2.5 | 37.3 ± 2.1 | 36.8 ± 2.5 | |
AD 100 | 38 ± 3 | 38.3 ± 1.6 | 36.8 ± 1.4 | 37.3 ± 2.8 | 37 ± 2.6 | 36.6 ± 1.8 | |
AD 200 | 37 ± 2.3 | 38.3 ± 2.3 | 37 ± 2 | 36.6 ± 2.2 | 37 ± 1.7 | 36.5 ± 2 | |
CO (L/min) | SAL | 2.5 ± 0.3 | 2.3 ± 0.5 | 2.6 ± 0.3 | 2.4 ± 0.3 | 2.5 ± 0.4 | 2.6 ± 0.2 |
AD 50 | 2.4 ± 0.28 | 2.4 ± 0.29 | 2.3 ± 0.33 | 2.3 ± 0.23 | 2.3 ± 0.30 | 2.5 ± 0.27 | |
AD 100 | 2.4 ± 0.36 | 2.5 ± 0.35 | 2.3 ± 0.32 | 2.2 ± 0.31 | 2.2 ± 0.21 | 2.3 ± 0.30 | |
AD 200 | 2.4 ± 0.35 | 2.5 ± 0.42 | 2.2 ± 0.32 | 2.1 ± 0.30 | 2.2 ± 0.21 | 2.3 ± 0.29 |
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Salah, E.; Abouelfetouh, M.M.; Englar, R.E.; Ding, M.; Ding, Y. Cardiorespiratory Effects of Three Infusion Doses of Adenosine in Conscious Goats: A Preliminary Study. Vet. Sci. 2021, 8, 158. https://doi.org/10.3390/vetsci8080158
Salah E, Abouelfetouh MM, Englar RE, Ding M, Ding Y. Cardiorespiratory Effects of Three Infusion Doses of Adenosine in Conscious Goats: A Preliminary Study. Veterinary Sciences. 2021; 8(8):158. https://doi.org/10.3390/vetsci8080158
Chicago/Turabian StyleSalah, Eman, Mahmoud M. Abouelfetouh, Ryane E. Englar, Mingxing Ding, and Yi Ding. 2021. "Cardiorespiratory Effects of Three Infusion Doses of Adenosine in Conscious Goats: A Preliminary Study" Veterinary Sciences 8, no. 8: 158. https://doi.org/10.3390/vetsci8080158