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Volume 9
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10.3390/gels9010024
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Article

Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage

by
Minhua Liu
1,†,
Yate Huang
1,†,
Chunwen Tao
1,
Weijia Yang
1,
Junrong Chen
1,
Li Zhu
1,
Tonghe Pan
1,
Ravin Narain
2,*,
Kaihui Nan
1,3,4,* and
Yangjun Chen
1,3,4,*
1
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325027, China
2
Department of Chemical and Materials Engineering, University of Alberta, Edmonton, AB T6G 2G6, Canada
3
National Engineering Research Center of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China
4
National Clinical Research Center for Ocular Diseases, Affiliated Eye Hospital of Wenzhou Medical University, Wenzhou 325027, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Gels 2023, 9(1), 24; https://doi.org/10.3390/gels9010024
Submission received: 22 November 2022 / Revised: 16 December 2022 / Accepted: 20 December 2022 / Published: 29 December 2022
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Abstract

Oxidative stress is considered as a major factor causing retinal pigment epithelium (RPE) dysfunction and finally leading to retinal diseases such as age-related macular degeneration (AMD). Developing hydrogels for RPE cell delivery, especially those with antioxidant feature, is emerging as a promising approach for AMD treatment. Herein, a readily prepared antioxidant alginate-based hydrogel was developed to serve as a cytoprotective agent for RPE cells against oxidative damage. Alg-BOB was synthesized via conjugation of benzoxaborole (BOB) to the polysaccharide backbone. Hydrogels were formed through self-crosslinking of Alg-BOB based on benzoxaborole-diol complexation. The resulting hydrogel showed porous micro-structure, pH dependent mechanical strength and excellent self-healing, remolding, and injectable properties. Moreover, the hydrogel exhibited excellent cytocompatibility and could efficiently scavenge reactive oxygen species (ROS) to achieve an enhanced viability of ARPE-19 cells under oxidative condition. Altogether, our study reveals that the antioxidant Alg-BOB hydrogel represents an eligible candidate for RPE delivery and AMD treatment.
Keywords: alginate; self-healing hydrogel; dynamic crosslinking; oxidative stress; retinal pigment epithelium alginate; self-healing hydrogel; dynamic crosslinking; oxidative stress; retinal pigment epithelium

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MDPI and ACS Style

Liu, M.; Huang, Y.; Tao, C.; Yang, W.; Chen, J.; Zhu, L.; Pan, T.; Narain, R.; Nan, K.; Chen, Y. Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage. Gels 2023, 9, 24. https://doi.org/10.3390/gels9010024

AMA Style

Liu M, Huang Y, Tao C, Yang W, Chen J, Zhu L, Pan T, Narain R, Nan K, Chen Y. Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage. Gels. 2023; 9(1):24. https://doi.org/10.3390/gels9010024

Chicago/Turabian Style

Liu, Minhua, Yate Huang, Chunwen Tao, Weijia Yang, Junrong Chen, Li Zhu, Tonghe Pan, Ravin Narain, Kaihui Nan, and Yangjun Chen. 2023. "Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage" Gels 9, no. 1: 24. https://doi.org/10.3390/gels9010024

APA Style

Liu, M., Huang, Y., Tao, C., Yang, W., Chen, J., Zhu, L., Pan, T., Narain, R., Nan, K., & Chen, Y. (2023). Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage. Gels, 9(1), 24. https://doi.org/10.3390/gels9010024

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