Helicobacter pylori (H. pylori) gastric infection is considered one of the most common human infections. It occurs in half of the world’s population is the most common cause of adenocarcinoma of the distal stomach [1].
The risk in developing gastric cancer is believed to be related to differences among H. pylori strains and the inflammatory responses mediated by host genetic factors.
The accepted evidence is that the H. pylori strains reach the stomach by ingestion through the mouth, and because of its non-invasive nature, the stomach is the definitive site for colonization [2,3].
One of the key issues related to the eradication of gastric H. pylori has been the importance of oral hygiene and periodontal procedures. Dental plaque control and periodontal therapy can prevent gastric H. pylori infection recurrence for patients with gastric diseases associated with H. pylori [4].
Conflicts of Interest
The Authors declare no conflict of interest.
References
- Atherton, J.C.; Cao, P.; Peek, R.M., Jr.; Tummuru, M.K.; Blaser, M.J.; Cover, T.L. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 1995, 270, 17771–17777. [Google Scholar] [CrossRef] [PubMed]
- Cave, D.R. Transmission and epidemiology of Helicobacter pylori. Am. J. Med. 1996, 100, 12S–17S. [Google Scholar] [CrossRef] [PubMed]
- Covacci, A.; Telford, J.L.; Del Giudice, G.; Parsonnet, J.; Rappuoli, R. Helicobacter pylori virulence and genetic geography. Science 1999, 284, 1328–1333. [Google Scholar] [CrossRef] [PubMed]
- Dunn, B.E.; Cohen, H.; Blaser, M.J. Helicobacter pylori. Clin. Microbiol. Rev. 1997, 10, 720–741. [Google Scholar] [CrossRef] [PubMed]
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).