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Proceedings, 2020, Eurachem 2020

The Virtual Eurachem Workshop 2020—“Quality Assurance for Analytical Laboratories in the University Curriculum”

online | 14–15 July 2020

Volume Editors:
Eugenia Eftimie Totu, University Politehnica of Bucharest, Romania
Ana Maria Joşceanu, University Politehnica of Bucharest, Romania

Number of Papers: 24
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Cover Story (view full-size image): The Eurachem Workshop, usually organized in connection with the Eurachem General Assembly, annually gathers a broad audience of specialists for quality assurance in chemistry, accreditation, [...] Read more.
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Editorial

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1 pages, 127 KiB  
Editorial
Eurachem—A Focus for Analytical Chemistry in Europe
by Vicki J Barwick
Proceedings 2020, 55(1), 19; https://doi.org/10.3390/proceedings2020055019 - 23 Oct 2020
Cited by 1 | Viewed by 1445
Abstract
Established in 1989, the aim of Eurachem is to provide a focus for analytical chemistry and [...] Full article

Research

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1 pages, 148 KiB  
Abstract
Validation of a Screening Method Based on a Needle Stochastic Sensor for the Determination of Interleukins 1β, 6, and 12 in Biological Samples
by Sorin Sebastian Gheorghe, Ruxandra Maria Ilie-Mihai, Raluca-Ioana Stefan-van Staden and Alexandru Bratei
Proceedings 2020, 55(1), 14; https://doi.org/10.3390/proceedings2020055014 - 10 Oct 2020
Viewed by 1062
Abstract
Interleukins proved to be valuable biomarkers for different diseases. Interleukins 1β, 6, and 12 can be used as biomarkers for brain cancer diagnosis, and therefore this paper proposed a needle stochastic sensor based on protoporphyrin IX immobilized in nano-diamond paste for fast screening [...] Read more.
Interleukins proved to be valuable biomarkers for different diseases. Interleukins 1β, 6, and 12 can be used as biomarkers for brain cancer diagnosis, and therefore this paper proposed a needle stochastic sensor based on protoporphyrin IX immobilized in nano-diamond paste for fast screening of biological samples, such as whole blood, urine and brain tumoral tissue, for these interleukins. The results obtained using this needle stochastic sensor proved that the interleukins 1β, 6, and 12 can be reliably determined from whole blood, urine and brain tumoral tissue, with recoveries higher than 96.00% and with relative standard deviations lower than 1.00%. The validation of the method was performed using whole blood and tissue samples collected from the patients confirmed with brain tumor. Full article
1 pages, 126 KiB  
Abstract
Good Laboratory Practice in Analytical Chemistry with Modern Laboratory Management
by Jacobus (Koos) Frederick van Staden
Proceedings 2020, 55(1), 23; https://doi.org/10.3390/proceedings2020055023 - 29 Oct 2020
Viewed by 1967
Abstract
Analytical chemistry is experiencing dramatic, turbulent change beyond laboratory and laboratory management control. Technological innovations, staffing demographics, new business models, automation, industry consolidation, society, regulatory expectations, and other factors are transforming nearly every aspect of analytical chemistry. This course takes a strategic view [...] Read more.
Analytical chemistry is experiencing dramatic, turbulent change beyond laboratory and laboratory management control. Technological innovations, staffing demographics, new business models, automation, industry consolidation, society, regulatory expectations, and other factors are transforming nearly every aspect of analytical chemistry. This course takes a strategic view of the laboratory system in the context of current quality management philosophies to determine options for achieving best practices. Experiences will be shared to provide insight into the obstacles and expected outcomes for the various approaches. Furthermore, this course includes the mission and function of the analytical enterprise, along with ways to improve the quality, performance, and evaluation of the laboratory for excellent benchmarking in giant industries. Full article
1 pages, 123 KiB  
Abstract
Uncertainty in the Classroom
by Wolfhard Wegscheider
Proceedings 2020, 55(1), 24; https://doi.org/10.3390/proceedings2020055024 - 19 Nov 2020
Viewed by 1096
Abstract
One of the more technically challenging concepts in quality assurance is the appropriate quantification of the uncertainty of measurement. Consequently, there must be an adequate emphasis on didactic approaches to ascertain that the student is not just educated about pertinent aspects, but actually [...] Read more.
One of the more technically challenging concepts in quality assurance is the appropriate quantification of the uncertainty of measurement. Consequently, there must be an adequate emphasis on didactic approaches to ascertain that the student is not just educated about pertinent aspects, but actually can apply the necessary procedures in his/her own field of expertise. “Student”, in this context, can denote very different stages in a career, from first-year students to doctoral students, as well as seasoned practitioners. Correspondingly, the teaching of measurement uncertainty can be quite diverse. In this contribution, specific examples of learning approaches towards “skills” will be provided based on past personal experience. Full article

Other

Jump to: Editorial, Research

4 pages, 341 KiB  
Proceeding Paper
Corrosion Protection of Carbon Steel Using Natural Seaweeds from Seawater
by Simona Căprărescu, Annette Madelene Dăncilă, Cristina Modrogan and Violeta Purcar
Proceedings 2020, 55(1), 1; https://doi.org/10.3390/proceedings2020055001 - 17 Sep 2020
Viewed by 1670
Abstract
The aim of this work was to investigate the corrosion inhibition effect of natural seaweeds in seawater on carbon steel. The corrosion efficiency of carbon steel in the absence and the presence of natural seaweeds in seawater was evaluated by the gravimetric method [...] Read more.
The aim of this work was to investigate the corrosion inhibition effect of natural seaweeds in seawater on carbon steel. The corrosion efficiency of carbon steel in the absence and the presence of natural seaweeds in seawater was evaluated by the gravimetric method at room temperature and calculating the corrosion rate and protection degree. The experimental results showed that the corrosion rate on carbon steel decreased when the seaweeds were used. In addition, the value of protection degree (P) was greater than 60% when seaweeds were used. Natural seaweeds reduce the corrosion rate and can be considered an ecofriendly corrosion inhibitor for carbon steel. Full article
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5 pages, 217 KiB  
Proceeding Paper
Quality Assurance of Analytical Measurements—A Vital Element in Safety Performance in the Nuclear Field
by Elena Neacsu
Proceedings 2020, 55(1), 2; https://doi.org/10.3390/proceedings2020055002 - 17 Sep 2020
Viewed by 1413
Abstract
The (International Atomic Energy Agency) IAEA’s fundamental safety objective is to protect people and the environment from harmful effects of ionizing radiation. The safety principles apply to all facilities and all activities to reduce existing radiation risks. Analytical quality assurance has gained in [...] Read more.
The (International Atomic Energy Agency) IAEA’s fundamental safety objective is to protect people and the environment from harmful effects of ionizing radiation. The safety principles apply to all facilities and all activities to reduce existing radiation risks. Analytical quality assurance has gained in importance in many scientific areas, including the analysis of radioactive specimens that require a thorough investigation and regulations for safety and ecological reasons. The use of certified reference materials is an essential pillar for the assessment of the quality of analytical data. Still, such matrix-matched certified reference materials are unfortunately not available for most investigations relevant to the nuclear domain. Therefore, other strategies have to be established, i.e., to compare the analytical results obtained for a particular instrumental technique, with data from another methodology whose analyte detection is based on a different physical principle. Full article
1 pages, 129 KiB  
Extended Abstract
Pros and Cons for the Laboratory Quality Management System in the Academic Environment
by David Milde
Proceedings 2020, 55(1), 3; https://doi.org/10.3390/proceedings2020055003 - 17 Sep 2020
Viewed by 1022
Abstract
Experience with the implementation of a quality management system (QMS) at the research laboratory of a public university in the Czech Republic will be presented in this talk. [...] Full article
1 pages, 153 KiB  
Extended Abstract
Validation of Disposable Stochastic Sensors Based on Nanolayer Depositon(s) of Silver and AgC Composite on Plastic for the Assay of α-Amylase in Whole Blood and Saliva
by Alexandrina Lungu-Moscalu, Raluca-Ioana Stefan-van Staden and Marius Badulescu
Proceedings 2020, 55(1), 4; https://doi.org/10.3390/proceedings2020055004 - 17 Sep 2020
Viewed by 1075
Abstract
Nanolayer deposition(s) of Ag and AgC composite on a plastic substrate was used to design disposable stochastic sensors. The first sensor was based on an Ag nanofilm deposited on plastic; for the second sensor, an AgC composite was deposited on plastic, and, for [...] Read more.
Nanolayer deposition(s) of Ag and AgC composite on a plastic substrate was used to design disposable stochastic sensors. The first sensor was based on an Ag nanofilm deposited on plastic; for the second sensor, an AgC composite was deposited on plastic, and, for the third sensor, on the plastic was deposited first a nanofilm of Ag and on top of it a nanofilm of the AgC composite. α-Cyclodextrin was used to modify the active surface of the sensor. Full article
3 pages, 205 KiB  
Proceeding Paper
Determination of Intrinsic and Metrological Correlations of Components of Product Impact on Risks of False Decisions in Conformity Assessment
by Luciana Separovic, Ricardo J. N. Bettencourt da Silva and Felipe Rebello Lourenço
Proceedings 2020, 55(1), 5; https://doi.org/10.3390/proceedings2020055005 - 18 Sep 2020
Cited by 2 | Viewed by 1427
Abstract
The correlation between the measured values of product components can influence the total risk of false decisions in conformity assessment. This correlation can originate from the characteristics of the product (intrinsic) or from how the components are measured (metrological). This work aimed to [...] Read more.
The correlation between the measured values of product components can influence the total risk of false decisions in conformity assessment. This correlation can originate from the characteristics of the product (intrinsic) or from how the components are measured (metrological). This work aimed to determine both correlations by testing a medicine with two compounds separately and together (correlated). The same intrinsic correlation was estimated regardless of whether the measurements were independent or correlated. Furthermore, the intrinsic covariance contributed significantly to the total covariance between the components evaluated. Both metrological and intrinsic correlations should be considered, as they can affect the risks of false decisions in conformity assessment when there are two or more compounds associated in the product. Full article
5 pages, 270 KiB  
Proceeding Paper
Implications of Matrix Effects in Quantitative HPLC/ESI-ToF-MS Analyses of Atmospheric Organic Aerosols
by Cornelia Amarandei, Romeo Iulian Olariu and Cecilia Arsene
Proceedings 2020, 55(1), 6; https://doi.org/10.3390/proceedings2020055006 - 21 Sep 2020
Cited by 2 | Viewed by 1788
Abstract
Matrix-induced signal suppression or enhancements are known phenomena in electrospray ionization mass spectrometry. Very few studies report on method development for organic aerosols analyses with the evaluation of the matrix effects. The matrix effects lead to errors in the quantification of the analytes [...] Read more.
Matrix-induced signal suppression or enhancements are known phenomena in electrospray ionization mass spectrometry. Very few studies report on method development for organic aerosols analyses with the evaluation of the matrix effects. The matrix effects lead to errors in the quantification of the analytes and affect the detection capability, precision, and accuracy of an analysis method. The present study reports on the matrix effects in the analysis of organic chemical compounds present in atmospheric aerosol particles collected on quartz filters. A total number of 19 analytes, including different classes of organic compounds, such as monoaromatic phenols and derivatives (e.g., catechol, 4-methylcatechol, 3-methoxycatechol, 4-nitrocatechol, 4-nitrophenol, 2,4-dinitrophenol, 2,6-dimethyl-4-nitrophenol), carboxylic acids (terebic acid, adipic acid, pimelic acid, phthalic acid, vanillic acid), and sulfonic acids (e.g., camphor-10-sulfonic acid), was investigated by high-performance liquid chromatography coupled to electrospray ionization time-of-flight mass spectrometry (HPLC/ESI-ToF-MS). The HPLC and ESI set-up parameters used in this study were previously optimized for the investigated compounds. Different volumes of a standard mixture were added to sample extracts, with final solutions concentrations in the 50–1500 μg L−1 range. For the investigated concentration range, the observed matrix effect was independent of the standard concentration level. For quartz filter extracts, the average matrix effect determined on a concentration-based method was 109.5 ± 6.1%. Both signal suppression and enhancement effects were observed for different compounds. For other analytes, the influence of the matrix effect is variable, suggesting that the use of an internal standard is not sufficient for the matrix effects correction. Competition between analyte ions and matrix components in the gas-phase ionization processes occurring in electrospray might explain signal suppression while generated coeluted isobaric compounds might induce signal enhancement. Full article
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6 pages, 504 KiB  
Proceeding Paper
The Importance of the Laboratory Quality Management System in the Academic Curriculum in Developing Appropriate Student Competences for Our Current Societal Needs
by Cecilia Arsene, Simona Maria Cucu Man and Romeo Iulian Olariu
Proceedings 2020, 55(1), 7; https://doi.org/10.3390/proceedings2020055007 - 21 Sep 2020
Cited by 1 | Viewed by 2094
Abstract
Laboratory quality management system is a concept of utmost importance for industry and other economic sectors. Nowadays, even for university laboratories it is possible to have accredited tests according to standard ISO/IEC 17025. This paper demonstrates a way of evaluating the potential of [...] Read more.
Laboratory quality management system is a concept of utmost importance for industry and other economic sectors. Nowadays, even for university laboratories it is possible to have accredited tests according to standard ISO/IEC 17025. This paper demonstrates a way of evaluating the potential of academic experts to integrate successfully the quality management systems of a chemical analysis laboratory in the teaching process. However, designing an appropriate academic curriculum responding to our current societal needs is still very challenging. In teaching and developing practical competences in analytical quality assurance, training offered to students in aspects related to the validation of an analytical method including performance characteristics such as selectivity and specificity, linear range, sensitivity, limit of detection, limit of quantification, ruggedness, accuracy, precision, etc., are primary steps in the process of a complete understanding of quality management system topics. This contribution presents a compilation of the most important current developments in a university chemical analysis laboratory with good results in developing theoretical and practical skills in analytical quality assurance for students, graduates and postgraduates alike. Teaching students with an interdisciplinary approach allows them to gain knowledge in making connections between disciplines and theories, between practical problems and accumulated knowledge, and between society’s assumptions, expectations, and needs. Full article
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2 pages, 168 KiB  
Proceeding Paper
Quality and Reliability in Analytical Chemistry
by Raluca-Ioana Stefan-van Staden
Proceedings 2020, 55(1), 8; https://doi.org/10.3390/proceedings2020055008 - 21 Sep 2020
Viewed by 2935
Abstract
Quality and reliability are essential terms in analytical chemistry. Reliable analytical information implies quality. Maintaining the quality in time shows reliability. Evaluation of quality and reliability is essential for the validation of a new method of analysis. Learning good practice in analytical chemistry [...] Read more.
Quality and reliability are essential terms in analytical chemistry. Reliable analytical information implies quality. Maintaining the quality in time shows reliability. Evaluation of quality and reliability is essential for the validation of a new method of analysis. Learning good practice in analytical chemistry during undergraduate studies will improve the quality of the laboratories of analysis, by implementing highly reliable analytical methods. Full article
4 pages, 223 KiB  
Proceeding Paper
Virtual Screening of Compounds by Chemoinformatics Tools in the Chemistry Labs
by Amalia Stefaniu, Lucia Pirvu, Eleonora-Mihaela Ungureanu, Liviu Birzan, Gabriela Stanciu, Laura-Bianca Enache and Veronica Anastasoaie
Proceedings 2020, 55(1), 9; https://doi.org/10.3390/proceedings2020055009 - 22 Sep 2020
Viewed by 1501
Abstract
Virtual screening of compound libraries for property predictions has various applications such as: prediction of oxido-reduction potentials in view of molecular recognition, drug-likeness assessment, and design of new potential therapeutic agents, quantitative structure-property and activity relationships (QSPR/QSAR) modeling to design new structures and [...] Read more.
Virtual screening of compound libraries for property predictions has various applications such as: prediction of oxido-reduction potentials in view of molecular recognition, drug-likeness assessment, and design of new potential therapeutic agents, quantitative structure-property and activity relationships (QSPR/QSAR) modeling to design new structures and property predictions. Available free online platforms or specialized software provide us with vital help to design, characterize and evaluate molecular features and descriptors for imaginary systems or newly synthesized ones, to establish their potential for new applications by controlling and modeling their chemical/ biochemical behavior and properties. Predictions allow us to reduce the time spent, the cost of reagents or elaborate and costly assays, and provide us enlarged and complex perspectives. Full article
5 pages, 485 KiB  
Proceeding Paper
Development and Application of an LC-MS/MS Method for Identification of Polyphenols in Propolis Extract
by Madalina Maria Nichitoi, Teodor Costache, Ana Maria Josceanu, Raluca Isopescu, Gabriela Isopencu and Vasile Lavric
Proceedings 2020, 55(1), 10; https://doi.org/10.3390/proceedings2020055010 - 24 Sep 2020
Cited by 2 | Viewed by 1837
Abstract
: We identified and quantified by LC-MS/MS 11 (quercetin, galangin, pinocembrin, kaempferol, vanillin, chrysin, gallic acid, p-coumaric acid, trans-ferulic acid, caffeic acid, and caffeic acid phenethyl ester) out of the 21 polyphenolic compounds we looked for in ethanolic (25% and 50%) and [...] Read more.
: We identified and quantified by LC-MS/MS 11 (quercetin, galangin, pinocembrin, kaempferol, vanillin, chrysin, gallic acid, p-coumaric acid, trans-ferulic acid, caffeic acid, and caffeic acid phenethyl ester) out of the 21 polyphenolic compounds we looked for in ethanolic (25% and 50%) and aqueous propolis extracts by comparison with standards and literature data. Full article
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2 pages, 155 KiB  
Proceeding Paper
Teaching Metrology and Examinology in Chemistry at the University
by Ricardo J. N. Bettencourt da Silva
Proceedings 2020, 55(1), 11; https://doi.org/10.3390/proceedings2020055011 - 27 Sep 2020
Viewed by 1247
Abstract
This communication presents the teaching experience of Ricardo Bettencourt da Silva in the scientific areas of metrology and examinology in chemistry at various universities. Full article
3 pages, 298 KiB  
Proceeding Paper
From Characterisation to Validation: A Journey through Master’s Level Analytical Chemistry
by Victoria Hilborne and Anna Roffey
Proceedings 2020, 55(1), 12; https://doi.org/10.3390/proceedings2020055012 - 8 Oct 2020
Viewed by 1384
Abstract
The master’s degree in Applied Analytical Chemistry at University College London (UCL) includes valuable teaching input from the UK National Measurement Laboratory for Chemical and Bio-Measurement hosted at LGC. The course starts by introducing accuracy, sensitivity, specificity, trueness, and precision for validating analytical [...] Read more.
The master’s degree in Applied Analytical Chemistry at University College London (UCL) includes valuable teaching input from the UK National Measurement Laboratory for Chemical and Bio-Measurement hosted at LGC. The course starts by introducing accuracy, sensitivity, specificity, trueness, and precision for validating analytical chemistry measurement methods. The principles of proficiency tests, quality control, ruggedness, and associated statistics are practiced using a wide variety of case studies. Full article
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3 pages, 689 KiB  
Proceeding Paper
Assessment of the Dynamic Parameters of an Ion-Selective Microsensor
by Eugenia Eftimie Totu, Ibrahim Isildak, Daniel Costinel Petre, Selim Işildak, Mustafa Niğde, Özlem Tavukçuoğlu, Ridvan Yildirim, Tiberiu Totu and Ismail Ağır
Proceedings 2020, 55(1), 13; https://doi.org/10.3390/proceedings2020055013 - 9 Oct 2020
Viewed by 1323
Abstract
We report the statistical parameters associated with the dynamic characteristics of a calcium microelectrode. The electrochemical behavior of the obtained microsensor was assessed against the main interferents. Full article
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4 pages, 590 KiB  
Proceeding Paper
Quality Control of Metaxa Cognac
by Andreea Donise, Gabriela Nita, Mihaela Emanuela Craciun and Mihaela Mihai
Proceedings 2020, 55(1), 15; https://doi.org/10.3390/proceedings2020055015 - 12 Oct 2020
Viewed by 1299
Abstract
Quality represents all the characteristics and features of a product or service that satisfies individual requirements. In other words, quality is measured by the degree of customer satisfaction regarding a product or service. The implementation of the control diagram is studied at the [...] Read more.
Quality represents all the characteristics and features of a product or service that satisfies individual requirements. In other words, quality is measured by the degree of customer satisfaction regarding a product or service. The implementation of the control diagram is studied at the distribution store reception of Metaxa cognac orders. The delivery was performed in boxes of six bottles. The control charts follow the degree of filling of the bottles. The volume of filling was measured on a batch of 36 bottles to establish reliable control limits. The studied sample comprised 36 bottles distributed in six boxes. Full article
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2 pages, 177 KiB  
Extended Abstract
Internal Quality Control Using the Nordic Trollbook Yesterday, Today, and Tomorrow
by Bertil Magnusson
Proceedings 2020, 55(1), 16; https://doi.org/10.3390/proceedings2020055016 - 23 Oct 2020
Viewed by 1016
Abstract
When using a method routinely in a laboratory to deliver measurement results daily to a factory to monitor a process, we can have several scenarios. [...] Full article
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2 pages, 173 KiB  
Extended Abstract
Measurement Uncertainty and Conformity Assessment in Analytical Measurement—Considerations for the University Curriculum
by Stephen L. R. Ellison
Proceedings 2020, 55(1), 17; https://doi.org/10.3390/proceedings2020055017 - 23 Oct 2020
Viewed by 983
Abstract
Many analytical measurements are made in order to check a system or product for conformity [...] Full article
1 pages, 145 KiB  
Extended Abstract
You Talk, We Understand—The Importance of a Common Language of Measurement
by Vicki J Barwick
Proceedings 2020, 55(1), 18; https://doi.org/10.3390/proceedings2020055018 - 23 Oct 2020
Viewed by 1136
Abstract
The basic principles of metrology (the science of measurement) are the same across disciplines. [...] Full article
1 pages, 119 KiB  
Extended Abstract
Basic Elements of Quality Assurance for University Graduates—Practical Needs based on Thirty Years of Experience
by Kyriacos C. Tsimillis
Proceedings 2020, 55(1), 20; https://doi.org/10.3390/proceedings2020055020 - 26 Oct 2020
Viewed by 938
Abstract
Over the last few decades, the operation of the Single European Market and the task to eliminate technical barriers to trade underlined the need for adequate and reliable quality infrastructure. [...] Full article
2 pages, 205 KiB  
Extended Abstract
National Metrology Infrastructure—Support for Analytical Laboratory Activity
by Mirella Buzoianu
Proceedings 2020, 55(1), 21; https://doi.org/10.3390/proceedings2020055021 - 26 Oct 2020
Viewed by 1161
Abstract
Reliable, traceable, and comparable measurements provide a rational basis for evaluating the quality of any result and the starting point for laboratory accreditation. Accurate and compatible measurements are, at present, essential for manufacturing, science, and trade. Additionally, a wide range of aspects of [...] Read more.
Reliable, traceable, and comparable measurements provide a rational basis for evaluating the quality of any result and the starting point for laboratory accreditation. Accurate and compatible measurements are, at present, essential for manufacturing, science, and trade. Additionally, a wide range of aspects of the quality of life, from healthcare to sport, is underpinned by reliable measurement results. Starting from the role of a National Institute of Metrology (INM) in securing traceability of all measurements, regardless of their end-use or level of accuracy, some aspects related to the present state-of-art in the field of metrology in Romania are presented. Full article
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4 pages, 365 KiB  
Proceeding Paper
Open Educational Resources for Learning Environmental Analysis
by Camelia Draghici
Proceedings 2020, 55(1), 22; https://doi.org/10.3390/proceedings2020055022 - 29 Oct 2020
Viewed by 1208
Abstract
It is accepted that the COVID-19 pandemic opened the interest for open learning/education, for which there are three accepted meanings: (i) open universities, (ii) massive open online courses (MOOCs), and (iii) open educational resources (OERs). In this context, this work presents the development [...] Read more.
It is accepted that the COVID-19 pandemic opened the interest for open learning/education, for which there are three accepted meanings: (i) open universities, (ii) massive open online courses (MOOCs), and (iii) open educational resources (OERs). In this context, this work presents the development of OERs for learning about the environmental quality monitoring system and its related activities, where environmental analysis is a critical stage part of the process. The contents of the created OERs include video presentation/commented slides, text-based learning resources, and intermediate/final tests, available for free in the public domain. Full article
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