Next Article in Journal
Health-Promoting Activities Performed by Nurses for Patients with COPD
Previous Article in Journal
Hypofractionated Conformal Radiotherapy in Combination with Chemotherapy in Limited Disease Small Cell Lung Cancer Patients
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
ARM
Volume 82
Issue 2
10.5603/PiAP.2014.0017
arm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Analysis of Treatment Results in Primary Germ Cell Tumours with Mediastinal Location: Own Experience

by
Dariusz M. Kowalski
1,*,
Magdalena Knetki-Wróblewska
1,
Kinga Winiarczyk
1,
Piotr Jaśkiewicz
1,
Tadeusz Orłowski
2,
Renata Langfort
3,
Maciej Krzakowski
1 and
Michał Olszewski
4
1
Lung Cancer and Chest Tumours Department, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, ul. Roentgena 5, 02-781 Warszawa, Poland
2
Chest Surgery Department, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
3
Pathology Unit, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland
4
Radiodiagnostic Unit, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, 02-781 Warszawa, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2014, 82(2), 116-124; https://doi.org/10.5603/PiAP.2014.0017
Submission received: 17 July 2013 / Revised: 25 February 2014 / Accepted: 25 February 2014 / Published: 25 February 2014

Abstract

Introduction: Primary germ cell tumours with mediastinal location comprise 1–6% of mediastinal tumours and 2–5% of all germ cell tumours occurring in adults. They are identified mostly in the 3rd decade of life, in 90% of cases in men. The most common symptoms are dyspnea, chest pain, cough, fever and weight loss. The aim of the present study was the analysis of our own results of treatment of primary germ cell tumours with mediastinal location, and a review of the literature concerning this subject. Material and Methods: Five patients (4 males, 1 female) median age 27.8 years (range 23–30 years) treated in the period from 1999 to 2009 in Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Department of Lung Cancer and Chest Tumours in Warsaw, due to germinal tumours with primary mediastinal location, entered the study. Results: All patients received chemotherapy according to the BEP regimen. All patients achieved an objective response to treatment. Two patients died due to disease progression in spite of II- and III-line treatment. Three patients are still in follow-up. The median survival time was 55.8 months (range 8.0–120.0 months). Conclusions: Primary mediastinal germ cell tumours have worse prognosis than do those with gonadal location. Based on our observations and review of the literature, it can be concluded that the results of treatment of non-seminoma type germ cell tumours with primary mediastinal location remain poor. Patients who develop early recurrence or progression during first-line chemotherapy are particularly at risk of unfavourable outcome. Identification of new standards of treatment in tumours resistant to cisplatin require further studies evaluating the effectiveness of new generation cytostatic drugs.
Keywords: germ cell tumours; mediastinum; chemotherapy; radiotherapy germ cell tumours; mediastinum; chemotherapy; radiotherapy

Share and Cite

MDPI and ACS Style

Kowalski, D.M.; Knetki-Wróblewska, M.; Winiarczyk, K.; Jaśkiewicz, P.; Orłowski, T.; Langfort, R.; Krzakowski, M.; Olszewski, M. Analysis of Treatment Results in Primary Germ Cell Tumours with Mediastinal Location: Own Experience. Adv. Respir. Med. 2014, 82, 116-124. https://doi.org/10.5603/PiAP.2014.0017

AMA Style

Kowalski DM, Knetki-Wróblewska M, Winiarczyk K, Jaśkiewicz P, Orłowski T, Langfort R, Krzakowski M, Olszewski M. Analysis of Treatment Results in Primary Germ Cell Tumours with Mediastinal Location: Own Experience. Advances in Respiratory Medicine. 2014; 82(2):116-124. https://doi.org/10.5603/PiAP.2014.0017

Chicago/Turabian Style

Kowalski, Dariusz M., Magdalena Knetki-Wróblewska, Kinga Winiarczyk, Piotr Jaśkiewicz, Tadeusz Orłowski, Renata Langfort, Maciej Krzakowski, and Michał Olszewski. 2014. "Analysis of Treatment Results in Primary Germ Cell Tumours with Mediastinal Location: Own Experience" Advances in Respiratory Medicine 82, no. 2: 116-124. https://doi.org/10.5603/PiAP.2014.0017

APA Style

Kowalski, D. M., Knetki-Wróblewska, M., Winiarczyk, K., Jaśkiewicz, P., Orłowski, T., Langfort, R., Krzakowski, M., & Olszewski, M. (2014). Analysis of Treatment Results in Primary Germ Cell Tumours with Mediastinal Location: Own Experience. Advances in Respiratory Medicine, 82(2), 116-124. https://doi.org/10.5603/PiAP.2014.0017

Article Metrics

Back to TopTop