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Clocks & Sleep, Volume 7, Issue 3

2025 September - 23 articles

Cover Story: Individuals with neurodevelopmental disorders (NDDs) are vulnerable to sleep disruption and light exposure at night, but it remains unclear whether the adverse effects stem from light itself or from circadian misalignment. In the Cntnap2 KO model, the effects of dim light at night (DLaN) and of an ultradian T7 cycle (3.5 h light/3.5 h dark) were compared. DLaN exacerbated social deficits and repetitive grooming and evoked cFos expression in the amygdala. The T7 cycle modestly reduced rhythm strength without worsening these behaviors or neural markers. These results suggest that circadian disruption, not light exposure alone, drives the adverse effects of nighttime light. Our findings highlight circadian stability as a protective factor and suggest interventions targeting circadian alignment may mitigate behavioral vulnerability in NDDs. View this paper
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Articles (23)

  • Article
  • Open Access
1,478 Views
21 Pages

Sleepiness and Fatigue as Consequences of Cumulative Sleep Restriction: Insights from Fine-Grained Subjective Measures and Skin Temperature in the Field

  • Vaida T. R. Verhoef,
  • Karin C. H. J. Smolders,
  • Geert Peeters,
  • Sebastiaan Overeem and
  • Yvonne A. W. de Kort

Diagnosis and monitoring of daytime sleepiness remain challenging and are strongly reliant on subjective assessments. To revisit common monitoring tools and explore new assessment modalities, we investigated the response of daily and momentary subjec...

  • Review
  • Open Access
1,699 Views
14 Pages

Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent disorder in the pediatric population. Furthermore, there appears to be a special relationship between ADHD and Restless Legs Syndrome (RLS). The objective of this review was therefore to...

  • Article
  • Open Access
1,784 Views
12 Pages

Sleep in intensive care unit (ICU) patients is frequently disrupted, which may adversely affect their overall health and recovery. Despite the implementation of various strategies to promote sleep, accurately assessing its quality remains complex. Th...

  • Article
  • Open Access
1,451 Views
17 Pages

Dissociating the Effects of Light at Night from Circadian Misalignment in a Neurodevelopmental Disorder Mouse Model Using Ultradian Light–Dark Cycles

  • Sophia Anne Marie B. Villanueva,
  • Huei-Bin Wang,
  • Kyle Nguyen-Ngo,
  • Caihan Tony Chen,
  • Gemma Stark,
  • Gene D. Block,
  • Cristina A. Ghiani and
  • Christopher S. Colwell

Individuals with neurodevelopmental disorders (NDDs) often experience sleep disturbances and are frequently exposed to light during nighttime hours. Our previous studies using the Contactin-associated protein-like 2 (Cntnap2) knockout (KO) mouse mode...

  • Review
  • Open Access
1 Citations
4,593 Views
26 Pages

Sleep, Physical Activity, and Executive Functions in Students: A Narrative Review

  • Giulia Belluardo,
  • Debora Meneo,
  • Silvia Cerolini,
  • Chiara Baglioni and
  • Paola De Bartolo

The school and university periods represent a critical phase in individuals’ cognitive, emotional, and behavioural development. Numerous lifestyle factors can influence executive functions and high-level cognitive processes crucial for learning...

  • Review
  • Open Access
1,866 Views
14 Pages

Concussion Disrupts Sleep in Adolescents: A Systematic Review and Meta-Analysis

  • Suleyman Noordeen,
  • Poh Wang,
  • Anna E. Strazda,
  • Eszter Sara Arany,
  • Mehmet Ergisi,
  • Linghui Janice Yeo,
  • Rebeka Popovic,
  • Abinayan Mahendran,
  • Mikail Khawaja and
  • Yizhou Yu
  • + 5 authors

Concussions significantly impact sleep quality among adolescents. Despite increasing recognition of these effects, the complex relationship between adolescent concussions and sleep disturbances is still not fully understood and presents mixed finding...

  • Article
  • Open Access
2,166 Views
14 Pages

The Acute Effects of Morning Bright Light on the Human White Adipose Tissue Transcriptome: Exploratory Post Hoc Analysis

  • Anhui Wang,
  • Jeroen Vreijling,
  • Aldo Jongejan,
  • Valentina S. Rumanova,
  • Ruth I. Versteeg,
  • Andries Kalsbeek,
  • Mireille J. Serlie,
  • Susanne E. la Fleur,
  • Peter H. Bisschop and
  • Dirk J. Stenvers
  • + 1 author

The circadian rhythm of the central brain clock in the suprachiasmatic nucleus (SCN) is synchronized by light. White adipose tissue (WAT) is one of the metabolic endocrine organs containing a molecular clock, and it is synchronized by the SCN. Excess...

  • Article
  • Open Access
1,189 Views
19 Pages

Sleep Quality and Patient Activation in Chronic Disease: A Cross-Sectional Mediation Analysis

  • Christian J. Wiedermann,
  • Verena Barbieri,
  • Stefano Lombardo,
  • Timon Gärtner,
  • Klaus Eisendle,
  • Giuliano Piccoliori,
  • Adolf Engl and
  • Dietmar Ausserhofer

Patient activation enhances self-management of chronic illnesses, and sleep quality is vital for health. The link between activation and sleep quality and the mediating role of chronic diseases remain underexplored. This study examined the associatio...

  • Case Report
  • Open Access
1,425 Views
9 Pages

Hypersomnia may be classified as primary or secondary, with secondary hypersomnia arising from a variety of underlying causes. Thus, according to ICSD3-TR classification, the diagnosis of idiopathic hypersomnia (IH) is established based on (1) excess...

  • Article
  • Open Access
750 Views
13 Pages

Polygraphic Results in High-Risk Infants Aged Under 3 Months

  • Daniel Zenteno,
  • Gerardo Torres-Puebla,
  • Camila Sánchez,
  • Rocío Gutiérrez,
  • María José Elso and
  • Pablo E. Brockmann

This study described and analyzed the results of cardiorespiratory polygraphic studies in infants under three months who were hospitalized and monitored due to suspected apneas. Methods: Cross-sectional study. Patients aged <3 months hospitalized...

  • Review
  • Open Access
3 Citations
8,429 Views
20 Pages

In humans, the master circadian clock, present in the suprachiasmatic nucleus, plays an important role in controlling life-sustaining functions. The development of the circadian clock begins in the fetal period and is almost completed during infancy...

  • Article
  • Open Access
3,671 Views
14 Pages

Who Benefits the Most from Sleep Hygiene Education? Findings from the SLeep Education for Everyone Program (SLEEP)

  • Alyssa Tisdale,
  • Nahyun Kim,
  • Dawn A. Contreras,
  • Elizabeth Williams and
  • Robin M. Tucker

This study examined data from participants who completed the SLeep Education for Everyone Program (SLEEP) to explore how various demographic variables affected sleep outcomes and to determine which participant characteristics predicted success. A tot...

  • Review
  • Open Access
2,952 Views
19 Pages

Short sleep has been linked to overweight, possibly via alterations in appetite-regulating hormones, but findings are inconsistent. Sex differences may contribute to this variability. This systematic review examines whether sex modifies the hormonal...

  • Article
  • Open Access
2,063 Views
12 Pages

Uvulopalatopharyngoplasty Versus Expansion Sphincter Pharyngoplasty: A Single Centre Experience

  • Teresa Bernadette Steinbichler,
  • Birte Bender,
  • Roland Hartl,
  • Verena Strasser,
  • Daniel Sontheimer,
  • Sladjana Buricic,
  • Barbara Kofler,
  • Birgit Högl,
  • Herbert Riechelmann and
  • Benedikt Hofauer

Background: Uvulopalatopharyngoplasty (UPPP) and expansion sphincter pharyngoplasty (ESP) are two standard surgical procedures for the treatment of snoring and obstructive sleep apnea. In a retrospective clinical trial, we compared the two surgical t...

  • Article
  • Open Access
1,144 Views
18 Pages

The circadian clock is a self-sustaining oscillator with a period of approximately 24 h, enabling organisms to anticipate daily recurring events, such as sunrise and sunset. Since the circadian period is not exactly 24 h and the environmental day len...

  • Article
  • Open Access
1,989 Views
19 Pages

Blood Metabolic Biomarkers of Occupational Stress in Healthcare Professionals: Discriminating Burnout Levels and the Impact of Night Shift Work

  • Andreea Petra Ungur,
  • Andreea-Iulia Socaciu,
  • Maria Barsan,
  • Armand Gabriel Rajnoveanu,
  • Razvan Ionut,
  • Carmen Socaciu and
  • Lucia Maria Procopciuc

Burnout syndrome is characterized mainly by three criteria (emotional exhaustion, depersonalization, and low personal accomplishment), and further exacerbated by night shift work, with profound implications for individual and societal well-being. The...

  • Article
  • Open Access
1,439 Views
26 Pages

The Owls Are Not What They Seem: Health, Mood, and Sleep Problems Reported by Morning and Evening Types with Atypical Timing of Weekend Sleep

  • Arcady A. Putilov,
  • Evgeniy G. Verevkin,
  • Dmitry S. Sveshnikov,
  • Zarina V. Bakaeva,
  • Elena B. Yakunina,
  • Olga V. Mankaeva,
  • Vladimir I. Torshin,
  • Elena A. Trutneva,
  • Michael M. Lapkin and
  • Vladimir B. Dorokhov
  • + 5 authors

Morningness-eveningness is usually assessed as either a trait or a state using either a morning–evening preference scale or sleep timing reported for free days, respectively. These assessments were implemented in numerous studies exploring the...

  • Article
  • Open Access
3,246 Views
14 Pages

Association Between Dreams, Anxiety, and Depressive Symptoms Among Japanese Adolescents: A Cross-Sectional Study

  • Yuki Tanaka,
  • Yuichiro Otsuka,
  • Suguru Nakajima,
  • Osamu Itani,
  • Tomomi Miyoshi and
  • Yoshitaka Kaneita

Worsening adolescent mental health is a significant social issue. Although dreams may reflect one’s mental state, few studies have focused on adolescents. Therefore, this study investigated the relationship between dream content and mental heal...

  • Review
  • Open Access
1,752 Views
15 Pages

Evaluation of the Circadian Rhythm Component Cipc (Clock-Interacting Pacemaker) in Leukemogenesis: A Literature Review and Bioinformatics Approach

  • Leidivan Sousa da Cunha,
  • Beatriz Maria Dias Nogueira,
  • Flávia Melo Cunha de Pinho Pessoa,
  • Caio Bezerra Machado,
  • Deivide de Sousa Oliveira,
  • Manoel Odorico de Moraes Filho,
  • Maria Elisabete Amaral de Moraes,
  • André Salim Khayat and
  • Caroline Aquino Moreira-Nunes

Circadian rhythms (CRs) are a key biological system regulating physiological processes such as metabolism, cell growth, DNA repair, and immunity, adapting to environmental changes like the light/dark cycle. Governed by internal clocks, it modulates g...

  • Article
  • Open Access
3,611 Views
11 Pages

Enhancing Sleep Quality: The Impact of the “Repose Tao” Pillow with Taopatch® Nanotechnology—A Pilot Study

  • Francesca Campoli,
  • Francesca Orofino,
  • Giuseppe Messina,
  • Donatella Di Corrado and
  • Vincenzo Cristian Francavilla

Background. Sleep disorders are a group of conditions that disrupt normal sleep patterns and are among the most common clinical challenges faced today. An innovative device that employs nanotechnology to deliver beneficial effects on the human body i...

  • Article
  • Open Access
2 Citations
2,306 Views
12 Pages

Introduction: For patients in intensive care units, the Richards–Campbell Sleep Questionnaire (RCSQ) seems to be a useful tool for assessing sleep quality. However, its application in the Moroccan medical context could be limited due to the lac...

  • Article
  • Open Access
1 Citations
1,650 Views
17 Pages

ChronobioticsDB: The Database of Drugs and Compounds Modulating Circadian Rhythms

  • Ilya A. Solovev,
  • Denis A. Golubev,
  • Arina I. Yagovkina and
  • Nadezhda O. Kotelina

Chronobiotics represent a pharmacologically diverse group of substances, encompassing both experimental compounds and those utilized in clinical practice, which possess the capacity to modulate the parameters of circadian rhythms. These substances in...

  • Review
  • Open Access
3 Citations
5,963 Views
24 Pages

Sleep is an essential part of everyday life and disturbed sleep can produce numerous deleterious effects on the body. An especially prevalent and detrimental subset of sleep disturbances are sleep disturbances that occur in patients during the postop...

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Clocks & Sleep - ISSN 2624-5175