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Chemistry, Volume 4, Issue 3

September 2022 - 29 articles

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Cover Story: A benzimidazolium-based organic cage was investigated as a potential antimicrobial and antifungal agent. The structure of the cage was obtained via synchrotron X-ray diffraction studies on single crystals of the cage, as hexafluorophosphate salt. The cage’s affinity for the nitrate anion was investigated by titration in pure acetonitrile, while the binding of chloride was investigated in a more competing medium (i.e., 20%v D2O/CD3CN). Considering the wide interest in (benz)imidazolium-based drugs, a series of experiments were performed to test the cytotoxicity of the cage compounds on a human-derived cell line, SH-SY5Y, and their potential application as antifungal and antibacterial agents. Preliminary investigations on the cage as an anion transporter across membranes were also performed. View this paper

Articles (29)

  • Article
  • Open Access
8 Citations
3,211 Views
16 Pages

Sorption-Assisted Ultrafiltration Hybrid Method for Treatment of the Radioactive Aqueous Solutions

  • Leon Fuks,
  • Agnieszka Miśkiewicz and
  • Grażyna Zakrzewska-Kołtuniewicz

16 September 2022

The paper presents results of studies on the possibility of using the ultrafiltration method supported by sorption on low-cost, easily accessible aluminosilicates to purify water contaminated with radionuclides. An aqueous solution contaminated with...

  • Article
  • Open Access
3 Citations
4,002 Views
16 Pages

16 September 2022

Ni(CO)4, Cr(CO)6, Co(CO)3NO are some of the most common precursors used for focused electron beam induced deposition. Some of the compounds, even though extensively used have high requirements when it comes to handling being, explosives, highly flamm...

  • Article
  • Open Access
96 Citations
4,077 Views
16 Pages

15 September 2022

In this study, we used the FP-LAPW technique based on density functional theory applied in WIEN2k code to examine the structural, electronic, elastic, and thermoelectric properties of cubic double perovskite Rb2InBiX6 (X = Cl, Br) compounds. The stru...

  • Review
  • Open Access
25 Citations
4,066 Views
16 Pages

Fabrication of Polymersomes: A Macromolecular Architecture in Nanotherapeutics

  • Pragya Pallavi,
  • Karthick Harini,
  • Pemula Gowtham,
  • Koyeli Girigoswami and
  • Agnishwar Girigoswami

13 September 2022

In consideration of the issues of drug delivery systems, the artificial vesicle structures composed of block copolymers called polymersomes recently gained considerable attention. The possibility of tuning the mechanical parameter and increasing the...

  • Article
  • Open Access
3 Citations
2,671 Views
12 Pages

12 September 2022

The photodynamic therapy (PDT) represents a non-invasive method with good results in the treatment of superficial tumors. PDT is based on a combination of two factors, namely, a non-toxic photosensitizing molecule and a light source; the photosensiti...

  • Review
  • Open Access
2 Citations
3,527 Views
6 Pages

Hydrotrifluoromethylation of Styrene and Phenylacetylene Derivatives under Visible-Light Photoredox Conditions

  • Amel Souibgui,
  • Mongi ben Mosbah,
  • Ridha ben Salem,
  • Younes Moussaoui and
  • Anis Tlili

6 September 2022

Photoredox processes have emerged recently as a powerful tool for methodology developments. In this context, the hydrotrifluoromethylation of alkenes and alkynes using visible light photoredox methodologies has proven its efficiency these last years....

  • Article
  • Open Access
7 Citations
4,207 Views
27 Pages

6 September 2022

The human myeloid leukemia cell differentiation protein (hMcl-1) is an anti-apoptotic multi-partner protein, belonging to the B-cell lymphoma-2 (Bcl-2) family of proteins. Studies have linked hMcl-1 alleviated expression with resistance to hemopoieti...

  • Article
  • Open Access
17 Citations
3,646 Views
14 Pages

Novel Quinazolinone–Isoxazoline Hybrids: Synthesis, Spectroscopic Characterization, and DFT Mechanistic Study

  • Yassine Rhazi,
  • Mohammed Chalkha,
  • Asmae Nakkabi,
  • Imad Hammoudan,
  • Mohamed Akhazzane,
  • Mohamed Bakhouch,
  • Samir Chtita and
  • Mohamed El Yazidi

30 August 2022

Quinazolinone and isoxazoline systems have attracted much attention due to their interesting pharmacological properties. The association of these two pharmacophores in a single hybrid structure can boost the biological activity or bring a new one. In...

  • Review
  • Open Access
63 Citations
22,134 Views
29 Pages

Recent Advances in Synthesis and Properties of Pyrazoles

  • María-Camila Ríos and
  • Jaime Portilla

29 August 2022

Pyrazole-containing compounds represent one of the most influential families of N-heterocycles due to their proven applicability and versatility as synthetic intermediates in preparing relevant chemicals in biological, physical-chemical, material sci...

  • Article
  • Open Access
6 Citations
2,502 Views
9 Pages

Silver Ions Incorporation into Nanofibers for Enhanced hMSC Viability

  • Natalya A. Sitnikova,
  • Anastasiya O. Solovieva,
  • Elizaveta S. Permyakova,
  • Alexander N. Sheveyko,
  • Dmitry V. Shtansky and
  • Anton M. Manakhov

29 August 2022

Antimicrobial properties of silver have been known for a long time, but there is also cytotoxicity of high concentrations of silver. Therefore, it is important to select the concentration and shape of silver depending on the goals. The ideal wound dr...

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