Chemistry, Volume 4, Issue 3
September 2022 - 29 articles
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Cover Story: A benzimidazolium-based organic cage was investigated as a potential antimicrobial and antifungal agent. The structure of the cage was obtained via synchrotron X-ray diffraction studies on single crystals of the cage, as hexafluorophosphate salt. The cage’s affinity for the nitrate anion was investigated by titration in pure acetonitrile, while the binding of chloride was investigated in a more competing medium (i.e., 20%v D2O/CD3CN). Considering the wide interest in (benz)imidazolium-based drugs, a series of experiments were performed to test the cytotoxicity of the cage compounds on a human-derived cell line, SH-SY5Y, and their potential application as antifungal and antibacterial agents. Preliminary investigations on the cage as an anion transporter across membranes were also performed. View this paper