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Volume 5
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10.3390/polysaccharides5030015
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Article

Graft Copolymers of Carboxymethyl Cellulose and Poly(N-vinylimidazole) as Promising Carriers for Metronidazole

by
Maria S. Lavlinskaya
1,*,
Anastasia A. Mikhaylova
2,
Egor I. Kuznetsov
2,
Ivan A. Zhuravlev
2,
Nikita A. Balbekov
2,
Igor A. Saranov
3 and
Andrey V. Sorokin
1,2
1
Biophysics and Biotechnology Department, Voronezh State University, 1 Universitetskaya Square, 394018 Voronezh, Russia
2
Chemical Faculty, Voronezh State University, 1 Universitetskaya Square, 394018 Voronezh, Russia
3
Research Core Center “Testing Center of Voronezh State University of Engineering Technologies”, Voronezh State University of Engineering Technologies, 19 Revolutsii Avenue, 394036 Voronezh, Russia
*
Author to whom correspondence should be addressed.
Polysaccharides 2024, 5(3), 198-211; https://doi.org/10.3390/polysaccharides5030015
Submission received: 11 May 2024 / Revised: 1 July 2024 / Accepted: 2 July 2024 / Published: 4 July 2024
(This article belongs to the Special Issue Latest Research on Polysaccharides: Structure and Applications)
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Abstract

Carboxymethyl cellulose sodium salt is a common water-soluble derivative of cellulose. It serves as a bioinert mucoadhesive material extensively used in biomedicine, particularly for crafting targeted drug delivery systems. In our study, we demonstrate that graft copolymers of sodium carboxymethyl-cellulose with poly(N-vinylimidazole) can function as carriers for the antibacterial drug metronidazole. Non-covalent associations form between the components, excluding the involvement of the nitro groups of the drug in the interaction. These loaded copolymers exhibit the capability to release the drug under conditions mimicking the stomach environment for up to 48 h. This renders the obtained associations promising candidates for the development of a metronidazole-targeted delivery system.
Keywords: carboxymethyl cellulose; metronidazole; graft copolymers; release kinetics carboxymethyl cellulose; metronidazole; graft copolymers; release kinetics

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MDPI and ACS Style

Lavlinskaya, M.S.; Mikhaylova, A.A.; Kuznetsov, E.I.; Zhuravlev, I.A.; Balbekov, N.A.; Saranov, I.A.; Sorokin, A.V. Graft Copolymers of Carboxymethyl Cellulose and Poly(N-vinylimidazole) as Promising Carriers for Metronidazole. Polysaccharides 2024, 5, 198-211. https://doi.org/10.3390/polysaccharides5030015

AMA Style

Lavlinskaya MS, Mikhaylova AA, Kuznetsov EI, Zhuravlev IA, Balbekov NA, Saranov IA, Sorokin AV. Graft Copolymers of Carboxymethyl Cellulose and Poly(N-vinylimidazole) as Promising Carriers for Metronidazole. Polysaccharides. 2024; 5(3):198-211. https://doi.org/10.3390/polysaccharides5030015

Chicago/Turabian Style

Lavlinskaya, Maria S., Anastasia A. Mikhaylova, Egor I. Kuznetsov, Ivan A. Zhuravlev, Nikita A. Balbekov, Igor A. Saranov, and Andrey V. Sorokin. 2024. "Graft Copolymers of Carboxymethyl Cellulose and Poly(N-vinylimidazole) as Promising Carriers for Metronidazole" Polysaccharides 5, no. 3: 198-211. https://doi.org/10.3390/polysaccharides5030015

APA Style

Lavlinskaya, M. S., Mikhaylova, A. A., Kuznetsov, E. I., Zhuravlev, I. A., Balbekov, N. A., Saranov, I. A., & Sorokin, A. V. (2024). Graft Copolymers of Carboxymethyl Cellulose and Poly(N-vinylimidazole) as Promising Carriers for Metronidazole. Polysaccharides, 5(3), 198-211. https://doi.org/10.3390/polysaccharides5030015

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