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Diabetology, Volume 6, Issue 9

2025 September - 17 articles

Cover Story: Besides insulin secretion stimulation, incretin-based therapies improve glycemic control due to inhibition of gastric acid secretion, delay gastric emptying, inhibit gut motility and induce satiety. We aimed to understand their role in modulating gastric fundus motility and the mechanisms involved in control and type 2 diabetic rats. Liraglutide inhibited the relaxation induced by SNP and NA, without affecting nNOS activity. In isolated rat gastric fundus pre-contracted with carbachol, GLP-1 receptor agonists liraglutide and exenatide induced receptor-dependent contractile responses. Thus, Liraglutide-induced increased gastric muscle tone may reduce gastric accommodation during food intake. This may contribute to the significant decrease in caloric intake and body weight in diabetic rats, being a peripheral mechanism involved in satiety. View this paper
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Articles (17)

  • Article
  • Open Access
1 Citations
1,236 Views
16 Pages

Therapeutic Adherence and Glycemic Control in the Population with Diabetes in Ceuta (Spain), a Multicultural City: A Cross-Sectional Study

  • Brieba del Río Pascual,
  • Antolí Jover Ana María,
  • Vázquez Lara Juana María,
  • Ruger Navarrete Azahara,
  • Vázquez Lara María Dolores,
  • Palomo Gómez Rocio,
  • Artero García Alejandro,
  • Rodríguez Díaz Luciano and
  • Fernández Carrasco Francisco Javier

22 September 2025

Diabetes mellitus constitutes a significant global public health problem. It is a chronic disease characterized by persistent hyperglycemia, which is a consequence of inadequate insulin secretion, deficient insulin action, or a combination of both fa...

  • Article
  • Open Access
1,290 Views
12 Pages

Prevalence of Sarcopenia in Very Old Diabetic and Non-Diabetic Hospitalized Patients

  • Sandra De Breucker,
  • Véronique Lachat,
  • Emilia Frangos,
  • Andrea Trombetti,
  • Ulrich Vischer,
  • Aline Mendes,
  • François R. Herrmann and
  • Christophe E. Graf

Background/Objectives: The prevalence of diabetes in very old people is rising sharply worldwide, due not only to obesity, nutritional and sedentary lifestyles, but also to aging per se. Diabetes is associated with a higher incidence of sarcopenia, m...

  • Article
  • Open Access
988 Views
14 Pages

The Impact of Cast Walker Design on Metabolic Costs of Walking and Perceived Exertion

  • Emily Standage,
  • Dylan Tookey,
  • Uchechukwu Ukachukwu,
  • Marco Avalos,
  • Ryan T. Crews and
  • Noah J. Rosenblatt

Background/Objectives: Cast walkers (CWs) are often prescribed to offload diabetic foot ulcers (DFUs). However, their mass, the degree of ankle immobilization and the limb length discrepancy they induce may increase the energetic demands of walking,...

  • Article
  • Open Access
2,412 Views
14 Pages

Background/Objectives: Type 2 diabetes (T2D) is associated with elevated cardiovascular risk and mortality. While physical activity can reduce cardiovascular risk, sustaining behavioral change remains challenging. Wearable activity trackers offer a s...

  • Article
  • Open Access
2,194 Views
15 Pages

Liraglutide Increases Gastric Fundus Tonus and Reduces Food Intake in Type 2 Diabetic Rats

  • Ana Catarina Carrêlo,
  • Beatriz Martins,
  • Raquel Seiça,
  • Carlos Fontes-Ribeiro,
  • Paulo Matafome and
  • Sónia Silva

Background/Objectives: Incretin-based therapies have demonstrated benefits in glycemic control and the prevention of long-term complications of diabetes. In addition to glucose-dependent insulin secretion stimulation, glucagon-like peptide-1 (GLP-1)...

  • Review
  • Open Access
1,319 Views
22 Pages

Diabetes mellitus (DM) and osteoporosis are among the most common non-communicable diseases worldwide. Beyond their considerable socio-economic burden, both conditions significantly impair quality of life and reduce life expectancy, representing majo...

  • Article
  • Open Access
4,558 Views
16 Pages

Comparison of Oscillometric Blood Pressure Measurements on the Arm and Forearm in Patients with Obesity, Prediabetes, and Hypertension

  • Tatiana Palotta Minari,
  • Luciana Pellegrini Pisani,
  • Tatiane de Azevedo Rubio,
  • Louise Buonalumi Tácito Yugar,
  • Luis Gustavo Sedenho-Prado,
  • Luciana Neves Cosenso-Martin,
  • Lúcia Helena Bonalume Tácito,
  • Heitor Moreno,
  • José Fernando Vilela-Martin and
  • Juan Carlos Yugar-Toledo

Background: The global surge in obesity has reignited the need for larger cuff sizes to avoid inaccurate blood pressure (BP) readings and inappropriate antihypertensive treatment. More precise methods are essential. Forearm BP measurement has emerged...

  • Communication
  • Open Access
1,316 Views
12 Pages

Abscisic Acid as a Marker of Metabolic Imbalance: Serum Levels from Diabetic and Smoking Subjects

  • Federico Abate,
  • Elisabetta Schiano,
  • Fabrizia Guerra,
  • Gaetano Piccinocchi,
  • Gian Carlo Tenore and
  • Ettore Novellino

Background: Abscisic acid (ABA), a phytohormone widely distributed in nature, has recently emerged as an endogenous regulator of glucose homeostasis in humans. Specifically, scientific studies have demonstrated that exogenous ABA supplementation impr...

  • Article
  • Open Access
972 Views
16 Pages

Alterations in Specific Fatty Acids and Phospholipids Are Associated with the Onset and Progression of Diabetes-like Phenotypes in High-Sugar Diet-Fed Fruit Flies

  • Sofía Estrada-Nieves,
  • David G. García-Gutiérrez,
  • Rosalía Reynoso-Camacho,
  • Alma D. Bertadillo-Jilote,
  • Juan R. Riesgo-Escovar,
  • Juan M. Murillo-Maldonado and
  • Iza F. Pérez-Ramírez

Background/Objectives: Obesity-related insulin resistance leads to the development of type 2 diabetes mellitus (T2DM); however, the pathophysiology of these metabolic alterations remains incompletely understood. This study aimed to characterize the l...

  • Article
  • Open Access
1,123 Views
16 Pages

Urinary Bisphenol Mixtures at Population-Exposure Levels Are Associated with Diabetes Prevalence: Evidence from Advanced Mixture Modeling

  • Mónica Grande-Alonso,
  • Clara Jabal-Uriel,
  • Soledad Aguado-Henche,
  • Manuel Flores-Sáenz,
  • Irene Méndez-Mesón,
  • Ana Rodríguez Slocker,
  • Laura López González,
  • Rafael Ramírez-Carracedo,
  • Alba Sebastián-Martín and
  • Rafael Moreno-Gómez-Toledano

Background/Objectives: There is a ubiquitous presence of plastics worldwide, and recent data highlight the continuous growth in their production and usage—a trend paralleled by the rise in chronic diseases like diabetes. The multifactorial natu...

  • Review
  • Open Access
2 Citations
6,162 Views
22 Pages

Youth-Onset Type 2 Diabetes: Update on Epidemiology, Pathophysiology, Diagnosis, and Management Strategies

  • Bruno Bombaci,
  • Stefano Passanisi,
  • Arianna Torre,
  • Serena Sbilordo,
  • Eleonora Inì,
  • Mattia Papa,
  • Mariella Valenzise,
  • Fortunato Lombardo and
  • Giuseppina Salzano

Youth-onset type 2 diabetes (T2D) is a growing public health challenge. This narrative review aims to provide a comprehensive overview of epidemiology, pathophysiology, diagnosis, complications, and therapeutic strategies in children and adolescents...

  • Commentary
  • Open Access
1,682 Views
14 Pages

The clinical case presented demonstrates how a person living with type 2 diabetes and treated with insulin reuses the same pen needle several times to save money and performs an incorrect maneuver while screwing the needle, which breaks, remains stuc...

  • Article
  • Open Access
1 Citations
1,304 Views
10 Pages

Multimorbidity Burden in Veterans with and Without Type 2 Diabetes Mellitus: A Comparative Retrospective Cohort Study

  • Lewis J. Frey,
  • Mulugeta Gebregziabher,
  • Kinfe G. Bishu,
  • Brianna Youngblood,
  • Jihad S. Obeid,
  • Jianlin Shi,
  • Patrick R. Alba,
  • Scott L. DuVall,
  • Christopher D. Blasy and
  • Chanita Hughes Halbert

Background/Objectives: Multimorbidity, where patients have ≥2 comorbidities, is recognized as a major challenge for health systems worldwide, driving up morbidity and cost. The differences in multimorbidity burden between those with and without ty...

  • Article
  • Open Access
1,476 Views
12 Pages

Background. Type 2 diabetes mellitus (T2D) and moderate-to-severe obstructive sleep apnea (OSA) commonly coexist and exacerbate poor glycemic control, systemic inflammation, and diminished quality of life (QoL). Although continuous positive airway pr...

  • Article
  • Open Access
1,152 Views
13 Pages

Permanence of Cognitive Alterations in Post- and Long COVID Patients: Glia and Brain Alteration, Gender Differences and New Diabetes Diagnosis

  • Concetta Mezzatesta,
  • Davide Brancato,
  • Francesca Provenzano,
  • Simone Marchese,
  • Maria Luisa Savona,
  • Sara Bazzano,
  • Rosa Gesualdo,
  • Francesco Cannia,
  • Angela Eleonora Porcino and
  • Vincenzo Provenzano
  • + 1 author

Background: COVID-19 has been associated with multisystemic sequelae, including persistent neurocognitive impairment and emerging metabolic alterations. Growing evidence suggests that glial dysfunction and inflammation may play a pivotal role in both...

  • Article
  • Open Access
2 Citations
2,034 Views
23 Pages

Background: The present study aims to evaluate the effectiveness of ESYSTA® (Emperra GmbH E-Health Technologies, Germany), a CE-certified digital health application made to support insulin-treated diabetes patients to improve their disease manage...

  • Article
  • Open Access
1,090 Views
12 Pages

Background/Objectives: Civic engagement may be a critical determinant of prognostic outcomes in persons with diabetes. Persons with diabetes are at increased risk for mobility impairment. Little research has explored the role of mobility difficulties...

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Diabetology - ISSN 2673-4540