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Volume 16
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Proceeding Paper

Synthesis of Novel Benzocaine and Procaine Glycodrugs †

by
Natividad Bejarano Rengel
,
Juliana Esteche
,
Cintia C. Santiago
and
Agustín Ponzinibbio
*
Centro de Estudio de Compuestos Orgánicos (CEDECOR), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 47 y 115, La Plata 1900, Argentina
*
Author to whom correspondence should be addressed.
†
Presented at the 28th International Electronic Conference on Synthetic Organic Chemistry (ECSOC-28), 15–30 November 2024; Available online: https://sciforum.net/event/ecsoc-28.
Chem. Proc. 2024, 16(1), 45; https://doi.org/10.3390/ecsoc-28-20119
Published: 14 November 2024
(This article belongs to the Proceedings of The 28th International Electronic Conference on Synthetic Organic Chemistry)
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Abstract

In this manuscript, we present the synthesis and structural identification of two novel glycodrugs derived from benzocaine and procaine. D-galactose was converted into a substrate suitable for the introduction of amino derivatives at the C6 position. The glycodrugs were obtained in good yields through a two-step process involving the formation of an imine followed by subsequent reduction.
Keywords: glycoside synthesis; p-aminobenzoate derivatives; 6-deoxy-6-N-aryl-galactosides glycoside synthesis; p-aminobenzoate derivatives; 6-deoxy-6-N-aryl-galactosides

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MDPI and ACS Style

Rengel, N.B.; Esteche, J.; Santiago, C.C.; Ponzinibbio, A. Synthesis of Novel Benzocaine and Procaine Glycodrugs. Chem. Proc. 2024, 16, 45. https://doi.org/10.3390/ecsoc-28-20119

AMA Style

Rengel NB, Esteche J, Santiago CC, Ponzinibbio A. Synthesis of Novel Benzocaine and Procaine Glycodrugs. Chemistry Proceedings. 2024; 16(1):45. https://doi.org/10.3390/ecsoc-28-20119

Chicago/Turabian Style

Rengel, Natividad Bejarano, Juliana Esteche, Cintia C. Santiago, and Agustín Ponzinibbio. 2024. "Synthesis of Novel Benzocaine and Procaine Glycodrugs" Chemistry Proceedings 16, no. 1: 45. https://doi.org/10.3390/ecsoc-28-20119

APA Style

Rengel, N. B., Esteche, J., Santiago, C. C., & Ponzinibbio, A. (2024). Synthesis of Novel Benzocaine and Procaine Glycodrugs. Chemistry Proceedings, 16(1), 45. https://doi.org/10.3390/ecsoc-28-20119

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