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Macromol, Volume 5, Issue 3

2025 September - 14 articles

Cover Story: Hydrogel-based biosensors have emerged as versatile tools in modern healthcare, combining biocompatibility, tunable structure, and stimuli-responsiveness for advanced diagnostics and therapy. Carbohydrate-derived hydrogels offer biodegradability, abundant functional groups, and integration with biosensing and drug delivery functions. These smart theranostic systems enable real-time monitoring of biomarkers, controlled drug release, and personalized treatment, with applications spanning diabetes, cancer, regenerative medicine, and postoperative care. This review highlights their structural versatility, dual functionality, and clinical potential for responsive, patient-centered healthcare. View this paper
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Articles (14)

  • Article
  • Open Access
1,129 Views
17 Pages

Interplay Between Protein Phosphatase 2A (PP2A) and SE Translocation (SET) as Macromolecular Target of Anticancer Compounds: A Combined Computational and Experimental Study

  • Giovanni Ribaudo,
  • Mario Angelo Pagano,
  • Margrate Anyanwu,
  • Matteo Giannangeli,
  • Marika Vezzoli,
  • Andrea Visentin,
  • Federica Frezzato,
  • Livio Trentin,
  • Anna Maria Brunati and
  • Alessandra Gianoncelli

12 September 2025

Cancer represents a leading cause of mortality globally, with its complex biological nature posing significant challenges for treatment. Central to cancer progression are molecular pathways that govern cellular function, among which protein phosphata...

  • Article
  • Open Access
1,152 Views
17 Pages

Study of Thermoplastic Starch/Poly (Butylene Succinate) Blends: The Effect of Reactive Compatibilizers

  • Ke Gong,
  • Yuanyuan Chen,
  • Yinshi Lu,
  • Zijian Zhao,
  • Alexandre Portela,
  • Han Xu,
  • Mengli Hu,
  • Handai Liu and
  • Maurice N. Collins

11 September 2025

Compatibilizers that enhance sustainability and improve the miscibility of polymer blend components have garnered significant attention. This study investigates the difference between the synthetic chain extender Joncryl® ADR 4468 and the natural...

  • Article
  • Open Access
879 Views
18 Pages

8 September 2025

Poly(butylene adipate-co-terephthalate) (PBAT) possesses mechanical properties and processing advantages comparable to low-density polyethylene (LDPE). However, its poor water vapor barrier properties (~2 orders of magnitude lower than LDPE) limit it...

  • Review
  • Open Access
3 Citations
5,096 Views
34 Pages

Starch Science Advancement: Isolation Techniques, Modification Strategies, and Multifaceted Applications

  • Abhijeet Puri,
  • Popat Mohite,
  • Aakansha Ramole,
  • Sonali Verma,
  • Milind Kamble,
  • Ketan Ranch and
  • Sudarshan Singh

8 September 2025

Starch is one of the most abundant biopolymers in nature and is widely utilized across various industries, including food, pharmaceuticals, textiles, and packaging. Its attractiveness stems from its renewability, biodegradability, versatility, and ab...

  • Article
  • Open Access
1,367 Views
13 Pages

Development of a Drug Delivery System with Bacterial Cellulose and Gelatin: Physicochemical and Microbiological Evaluation

  • Gabriel P. Machado,
  • Natasha L. A. Ibanez,
  • Patricia L. M. Alves,
  • Ana C. Chacon,
  • Larissa Simões,
  • Victoria Schultz,
  • Samanta Oliveira,
  • Denise Grotto and
  • Angela F. Jozala

27 August 2025

The growing threat of antimicrobial resistance drives the need for innovative and multifunctional therapeutic systems. In this study, a controlled-release system based on a bioactive film composed of gelatin, bacterial cellulose (BC), sericin, citric...

  • Review
  • Open Access
2,292 Views
18 Pages

Machine Learning for the Optimization of the Bioplastics Design

  • Neelesh Ashok,
  • Pilar Garcia-Diaz,
  • Marta E. G. Mosquera and
  • Valentina Sessini

14 August 2025

Biodegradable polyesters have gained attention due to their sustainability benefits, considering the escalating environmental challenges posed by synthetic polymers. Advances in artificial intelligence (AI), including machine learning (ML) and deep l...

  • Review
  • Open Access
1,263 Views
18 Pages

Smart Theranostic Platforms Based on Carbohydrate Hydrogels

  • Silvia Romano,
  • Sorur Yazdanpanah,
  • Raffaele Conte,
  • Agnello De Rosa,
  • Antonio Fico,
  • Gianfranco Peluso,
  • Parisa Pedram and
  • Arash Moeini

14 August 2025

Carbohydrate-based hydrogels represent a new advancement in the development of multifunctional biomedical systems, thanks to their intrinsic biocompatibility, structural versatility, and capacity for functional modification. This review examines the...

  • Review
  • Open Access
7 Citations
4,171 Views
26 Pages

Chemically Modified Alginate-Based Hydrogel-Matrices in Drug Delivery

  • Angélica Román-Guerrero,
  • Stefani Cortés-Camargo,
  • Erik Alpizar-Reyes,
  • Miriam Fabiola Fabela-Morón,
  • Julian Cruz-Olivares,
  • Sandra Karina Velázquez-Gutiérrez and
  • César Pérez-Alonso

12 August 2025

Alginate is a biomaterial that has demonstrated considerable potential and adaptability in the field of controlled drug delivery due to its unique physicochemical properties. Chemical modification of alginate has significantly enhanced its functional...

  • Article
  • Open Access
1,061 Views
15 Pages

Preparation of PLLA and PLGA Copolymers with Poly(ethylene adipate) Through Reactive Melt Mixing: Structural Characterization, Thermal Properties, and Molecular Mobility Insights

  • Evi Christodoulou,
  • Christina Samiotaki,
  • Alexandra Zamboulis,
  • Rizos Evangelos Bikiaris,
  • Panagiotis A. Klonos,
  • Apostolos Kyritsis and
  • Dimitrios N. Bikiaris

In this study, a series of copolymers was synthesized using the promising biodegradable polymers Poly(L-lactic acid) (PLLA), Poly(lactic-co-glycolic acid) (PLGA), and Poly(ethylene adipate) (PEAd), known for their high potential. PEAd was synthesized...

  • Review
  • Open Access
2 Citations
3,332 Views
30 Pages

Biopolymers in Biotechnology and Tissue Engineering: A Comprehensive Review

  • Maciej Grabowski,
  • Dominika Gmyrek,
  • Maria Żurawska and
  • Anna Trusek

Since the mid-19th century, researchers have explored the potential of bio-based polymeric materials for diverse applications, with particular promise in medicine. This review provides a focused and detailed examination of natural and synthetic biopo...

  • Article
  • Open Access
957 Views
17 Pages

Antibiotic-Coated Melt Electrowritten Polycaprolactone Meshes: Fabrication and In Vitro Antibacterial Evaluation

  • Joana Pinheiro Martins,
  • Ana Sofia de Sousa,
  • Sofia Costa de Oliveira,
  • António Augusto Fernandes and
  • Elisabete Teixeira da Silva

In recent years, pelvic organ prolapse (POP) cases have been rising, affecting women’s quality of life. Synthetic surgical transvaginal meshes used for POP treatment were withdrawn from the United States market in 2019 due to high risks, includ...

  • Article
  • Open Access
938 Views
16 Pages

Upcycling Microalgal Residues: Physicochemical Insights and Biocomposite Enhancement

  • Valerio Cuboni,
  • Raffaella Lettieri,
  • Alice Caravella,
  • Martina Corvino,
  • Viviana Scognamiglio,
  • Amina Antonacci and
  • Emanuela Gatto

The growing concern for environmental sustainability has led to an increased interest in biodegradable materials derived from renewable resources. This study explores the innovative use of residual biomass from the green photosynthetic microalga Chla...

  • Article
  • Open Access
656 Views
16 Pages

Poly(propylene thiophenedicarboxylate) (PPTh) is a new type of fully biobased polyester with excellent thermal, mechanical, and barrier properties; however, its practical application has been seriously restricted by the relatively slow crystallizatio...

  • Article
  • Open Access
1,078 Views
22 Pages

Innovative Cold Processing of PVOH-Based Composites: A Gate-to-Gate Life Cycle Assessment of Environmental Benefits

  • Andrea Marinelli,
  • Fulvio Seva,
  • Alberto Cigada,
  • Luca Paterlini,
  • MariaPia Pedeferri,
  • Maria Vittoria Diamanti and
  • Barbara Del Curto

Conventional thermoplastic polymer composites are produced using energy-intensive equipment. From an environmental perspective, reducing energy and material consumption, as well as selecting polymers and fillers that biodegrade without harmful conseq...

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Macromol - ISSN 2673-6209