Bing–Neel Syndrome: Update on Diagnosis and Treatment

Round 1

Reviewer 1 Report

(General comments)

 Wong et al wrote the comprehensive review of the Bing-Neel syndrome (BNS). The manuscript was well written, and informative. I have 3 minor concerns as bellow.

 

(Comments)

 

1.In 5.2. Laboratory features, it is essential to demonstrate WM cells themselves; the diagnosis cannot currently be made by measuring M protein in the CSF as a disrupted BBB may allow IgM seepage from the bloodstream (P4, line 135-137).                  

 I agree with the idea of M-protein in the CSF alone is not sufficient for making precise diagnosis of BNS, however, IgM index calculated by“[CSF IgM (mg/L) / serum IgM (g/L)] /[CSF albumin (mg/L) / serum albumin (g/L)]” is helpful for the diagnosis of BNS. Thus, could you comment the IgM index in 5.2. Laboratory features section.

 

2.In Table 1, the word “headache” is written in 2 places, and it is confusing.

 

Cognitive impairment, headache (27%)

Headache (18%)

 

Please check the Table is correct.

 

3. Many typos of MYD88^L264P (MYD88^L265P) are found in 5.2.3. Molecular features, Fig1, and Table2.

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This manuscript offers a complete review of the literature on BNS.

Some remarks:

- the paper would benefit from a general editing of English language and style

- line 30: occurred (not occurr)

- line 40 : apart from having (not apart from a having)

- line 41 there HAS been

- line 57: plasma cells disrupt (not plasma cells and disrupt)

- line 58 and 107 : parenchyma (not parenchymal)

- table 1: some features are reported twice (headache, paresis and motor symptoms/motor deficits); visual impairment OR disturbances (not VISUAL IMPAIRMENT OF DISTURBANCES)

- in the whole manuscript/figures/tables:  MYD88 L265P and not MYD88 L264P

- line 223 will guide (not will help guide) 

- line 224: WM not WN

- line 277: once BTK was recognised (not once BTKis were)

Author Response

Please see the attachment.

Author Response File: Author Response.pdf