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Nanomanufacturing, Volume 2, Issue 1

2022 March - 4 articles

Cover Story: Nanoparticles (NPs) are diverse nanostructures engineered into a variety of shapes, sizes, and surface chemistries with intended use for a broad range of therapeutic and non-therapeutic applications. Where NPs are used as therapeutic agents (e.g., nanomedicine), they must cross several physical barriers and mechanisms to overcome the cell membrane. Exploitable natural uptake mechanisms, namely, passive and endocytic are used to facilitate efficient cellular uptake. This review explores the exploitation of endocytic pathways for mainly inorganic non-spherical cellular uptake. Experimental determination of cellular uptake of different NPs in different environments can be laborious and expensive; therefore, we also review the role of mathematical modeling as a predictive tool for non-spherical NP cellular uptake. View this paper

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Articles (4)

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Article

7 Citations

4,276 Views

16 Pages

Amphiphilic P(OEGMA-co-DIPAEMA) Hyperbranched Copolymer/Magnetic Nanoparticle Hybrid Nanostructures by Co-Assembly

Dimitrios Selianitis,
Aleksander Forys,
Barbara Trzebicka,
Adam Alemayehu,
Václav Tyrpekl and
Stergios Pispas

Nanomanufacturing2022, 2(1), 53-68;https://doi.org/10.3390/nanomanufacturing2010004

1 March 2022

This work presents the utilization of amphiphilic poly(oligo(ethylene glycol) methyl methacrylate)-co-poly(2-(diisopropylamino)ethyl methacrylate), P(OEGMA-co-DIPAEMA), hyperbranched (HB) copolymers, forming polymeric aggregates in aqueous media, as...

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Article

8 Citations

5,848 Views

12 Pages

Lipid-Based Formulations Containing Labrafil M2125-CS: A Deep Investigation on Nanosystem Stability

Martine Tarsitano,
Maria Chiara Cristiano,
Antonia Mancuso,
Antonella Barone,
Daniele Torella and
Donatella Paolino

Nanomanufacturing2022, 2(1), 41-52;https://doi.org/10.3390/nanomanufacturing2010003

15 February 2022

Labrafil M2125-CS is a non-ionic surfactant component widely used for improving the solubilization of poor water-soluble drugs and as component of lipid-based nanosystem formulation. The aim of this research work was to evaluate in depth the stabilit...

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Feature Paper
Review

18 Citations

7,666 Views

24 Pages

Nanoimprinting of Biomimetic Nanostructures

Michael Muehlberger

Nanomanufacturing2022, 2(1), 17-40;https://doi.org/10.3390/nanomanufacturing2010002

9 February 2022

Biomimetic micro- and nano- structures have attracted considerable interest over the last decades for various applications ranging from optics to life sciences. The complex nature of the structures, however, presents significant challenges for fabric...

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Review

31 Citations

9,452 Views

16 Pages

Exploiting Endocytosis for Non-Spherical Nanoparticle Cellular Uptake

Saad Niaz,
Ben Forbes and
Bahijja Tolulope Raimi-Abraham

Nanomanufacturing2022, 2(1), 1-16;https://doi.org/10.3390/nanomanufacturing2010001

1 February 2022

Several challenges exist for successful nanoparticle cellular uptake—they must be able to cross many physical barriers to reach their target and overcome the cell membrane. A strategy to overcome this challenge is to exploit natural uptake mech...

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