2021 ECMS 2021 - 14 articles
Online | 1–14 September 2021
Volume Editors:
Claudiu T. Supuran, University of Florence, Italy
Clemente Capasso, National Research Council, Naples, Italy
Paola Gratteri, University of Florence, Italy
Silvia Selleri, University of Florence, Italy
Lymphocyte activation gene 3 (LAG-3) is a cell surface inhibitory receptor with multiple biological activities over T cell activation and effector functions [1,2,3]. LAG-3 negatively regulates proliferation, activation, effector function and homeosta...
Monoterpenes, which have a unique diverse structure and are inexpensive, available and often enantiomerically pure, are an attractive renewable raw material for the development of physiologically active agents. One of the most important methods for t...
Doxorubicin (DOX) is a chemotherapy drug that causes nephrotoxicity in rodent models and, to a lesser extent, in cancer patients. Doxorubicin hydrochloride or doxorubicin-loaded poly(lactide-co-glycolide acid) (Dox-PLGA) nanoparticles at a therapeuti...
The re-emergence of severe acute respiratory syndrome coronavirus 2 A(SARS-CoV-2) in Wuhan, China, has placed an unprecedented economic and health burden globally. The SARS-CoV-2 high mortality rate has brought great challenges to researchers, clinic...
Since new antibacterial agents against multi-drug resistant (MDR) bacteria are urgently needed, we recently synthetized cationic dendrimers and copolymers and assessed their antibacterial activity on numerous MDR clinical isolates. Being cationic, th...
A virus is a microorganism that uses the machinery of the host to multiply. At present, there are various species of viruses known to us that are dangerous for the health of human beings. One of such viruses has destroyed many lives nowadays and that...
Anisakiasis is a human parasitic infection caused by the larvae of the Anisakis nematode through the consumption of raw or undercooked seafood, namely fish and cephalopods. To date, no effective drug has been uncovered and common anthelmintic treatme...
Under the influence of many factors, such as cytokines or chemokines, macrophages specialize into two subpopulations: pro-inflammatory M1 (classical pathway) or anti-inflammatory M2 macrophages (alternative pathway). Upon stimulation with the bacteri...
The devastating nature of the SARS-CoV-2 pandemic has fostered the need for potent therapeutics to manage or curb the disease’s severity. As a response, several studies on drug repurposing, vaccine design and optimizing natural phytochemicals a...
Tuberculosis (TB) is a global health burden especially in tropical countries. Extensive increments in MDR (Multidrug resistance (MDR): Resistance to at least both isoniazid and rifampicin.) and XDR (Extensive drug resistance (XDR): Resistance to any...
An organism’s hypoxia tolerance depends on many factors, including age. High newborn organism tolerance and high levels of oxidative stress throughout aging have been demonstrated by many studies. However, there is still lack of investigations...
Linearolactone (LL) isolated from Salvia polystachya presents antiparasitic activity against E. histolytica and G. lamblia through ROS production, an apoptosis-like process, and alteration of the actin cytoskeleton. This effect limits the invasion an...
The high mortality rate of different multi-resistant bacteria (MDR) has led to an immediate and urgent solution. Patients hospitalized for chronic diseases have a weakened immune system and are at high risk of contracting an opportunistic infection....
Over the last few billion years, countless organisms populating our planet have produced an extensive reserve of very diverse chemicals called natural products (NPs). Over time, these compounds have evolved to exhibit a wide range of bioactivity and...
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