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Journal of Dementia and Alzheimer's Disease, Volume 1, Issue 2

2024 December - 3 articles

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Articles (3)

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Review

7 Citations

10,950 Views

17 Pages

Neural Stem Cell Therapy for Alzheimer’s Disease: A-State-of-the-Art Review

Abdul Jalil Shah,
Mohammad Younis Dar,
Bisma Jan,
Insha Qadir,
Reyaz Hassan Mir,
Jasreen Uppal,
Noor Zaheer Ahmad and
Mubashir Hussain Masoodi

J. Dement. Alzheimer's Dis.2024, 1(2), 109-125;https://doi.org/10.3390/jdad1020008

6 November 2024

Alzheimer’s disease (AD) is a brain disorder that is more prevalent in developed nations and remains one of most intractable conditions so far. It is characterized by a gradual onset, a prolonged progression, and an unclear pathophysiology. At...

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Article

1,936 Views

11 Pages

Analytic Challenges in Clinical Trials of Early Alzheimer’s Disease

Craig H. Mallinckrodt,
Ilya Lipkovich,
Suzanne B. Hendrix,
Samuel P. Dickson and
Geert Molenberghs

J. Dement. Alzheimer's Dis.2024, 1(2), 98-108;https://doi.org/10.3390/jdad1020007

21 October 2024

Background: The heavily right-skewed data seen in recently reported Alzheimer’s disease (AD) clinical trials influenced treatment contrasts when data were analyzed via the typical mixed-effects model for repeated measures (MMRM). Methods: An MM...

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Feature Paper
Review

12 Citations

9,196 Views

11 Pages

Endoplasmic Reticulum Stress in Neurodegenerative Diseases

Syed-Abdul-Moiz Hasan,
Antonisamy William James,
Farzeen M. Fazili,
Samiha Tarabishi,
Namir M. Sheikh and
Zahoor A. Shah

J. Dement. Alzheimer's Dis.2024, 1(2), 87-97;https://doi.org/10.3390/jdad1020006

15 October 2024

Endoplasmic reticulum (ER) stress is a detrimental cellular phenomenon in the cells and is activated by the accumulation of unfolded or misfolded proteins in the ER. The unfolded protein accumulation activates the unfolded protein response (UPR), an...

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J. Dement. Alzheimer's Dis. - ISSN 3042-4518

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