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Prof. Dr. Yang Wang

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College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, China
Interests: molecular pathogens and immunology of livestock and poultry; co-infection and synergistic pathogenic mechanism of pathogens; antibiotic resistance; quorum-sensing systems; biofilms; phage–microbe interaction; antimicrobial agents; plant extracts
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Special Issue Information

Dear Colleagues,

Geographical, demographic, environmental, and social characteristics have driven a global rapid development of the livestock and poultry industry. However, it is undeniable that this development has brought about significant issues, such as infectious diseases (and especially zoonotic infectious diseases), antibiotic resistance, and ecological issues. The harm caused by infectious diseases is second to none. The current scenario in bacteria-related infectious diseases in livestock and poultry has attracted the attention of researchers, prompting them to explore the epidemiology, pathogenic mechanisms, drug resistance and transmission mechanisms, as well as prevention and control strategies of livestock- and poultry-related bacteria.

We welcome researchers to submit their original research, reviews, and brief reports. The potential themes covered by this Special Issue include, but are not limited to, the following:

Epidemiology;
Pathogenic mechanisms;
Antimicrobial resistance mechanisms;
Emerging and endemic bacterial infections in livestock and poultry;
Development of accurate typing methods to track the dissemination of zoonotic bacteria;
Development of sustainable detection methods to tackle bacterial infections in livestock and poultry;
Strategies for preventing and controlling livestock- and poultry-related bacteria, such as vaccine development research, antivirulence therapies, and drugs.

Prof. Dr. Yang Wang
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

livestock and poultry
pathogens
pathogenesis
antimicrobial resistance
vaccines
antivirulence therapies and drugs
pathogen detection methods

Published Papers (2 papers)

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Research

13 pages, 1991 KiB

Open AccessArticle

Antimicrobial Resistance and Biofilm Formation of Bordetella bronchiseptica in Central China, with Evidence of a Rare Heteroresistance Strain to Gentamicin

by Li Yi, Haoran Fan, Shuo Yuan, Rishun Li, Haikun Wang, Yingying Quan, Hui Zhang, Yuxin Wang and Yang Wang

Animals 2024, 14(9), 1301; https://doi.org/10.3390/ani14091301 - 25 Apr 2024

Viewed by 325

Abstract

Bordetella bronchiseptica is a significant contributor to respiratory disease in pigs, leading to substantial economic losses in the swine industry worldwide. We isolated 52 B. bronchiseptica strains from 542 samples collected from pigs with atrophic rhinitis and bronchopneumonia in central China. Multi-locus sequence typing identified two prevalent sequence types: ST6 (69.23%) and ST7 (30.77%). PCR-based detection of seven virulence genes (fhaB, prn, cyaA, dnt, bteA, fla, and bfrZ) revealed that six of these genes were present in over 90% of the isolates, with bfrZ being the exception at 59.62%. Antimicrobial susceptibility testing, performed using the K-B method, demonstrated high sensitivity to enrofloxacin, polymyxin, and doxycycline but a notable resistance to tylosin, trimethoprim, tobramycin, ciprofloxacin, and amikacin. Remarkably, 86.54% of the isolates exhibited a multidrug-resistant phenotype. Notably, we successfully screened a strain of B. bronchiseptica with a heteroresistance phenotype to gentamicin using population analysis profiling, which is a rare case. Biofilm-formation assays indicated that 96.15% of the isolates possessed biofilm-forming capabilities. These findings provide crucial insights into the prevalence of B. bronchiseptica in central China, facilitating the development of effective preventive measures to safeguard both animal and human health. Full article

(This article belongs to the Special Issue Bacteria Disease Research in Livestock and Poultry: Epidemiology, Pathogenicity, Drug Resistance and Control)

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13 pages, 4164 KiB

Open AccessArticle

Comparative Genome Analysis of Two Streptococcus suis Serotype 8 Strains Identifies Two New Virulence-Associated Genes

by Qi Sheng, Qiuhua Xu, Zouran Lan and Zongfu Wu

Animals 2024, 14(4), 572; https://doi.org/10.3390/ani14040572 - 08 Feb 2024

Viewed by 792

Abstract

Streptococcus suis is an important zoonotic pathogen that can cause meningitis and septicemia in swine and humans. Among numerous pathogenic serotypes, S. suis serotype 8 has distinctive characteristics such as a high detection rate and causing multi-host infection. There is no complete genome of serotype 8 strains so far. In this study, the complete genome of two S. suis serotype 8 strains, virulent strain 2018WUSS151 and non-virulent strain WUSS030, were sequenced. Comparative genomic analysis showed that the homology of the two genomes reaches 99.68%, and the main difference is the distinctive prophages. There are 83 genes unique to virulent strain 2018WUSS151, including three putative virulence-associated genes (PVGs). Two PVGs, padR and marR, are passenger genes in ISSsu2 family transposons that are able to form circular DNA intermediates during transposition, indicating the possibility of horizontal transmission among S. suis strains. The deletion mutant of PVGs marR or atpase attenuated the virulence of serotype 2 virulent SC070731 in a mouse infection model, confirming their role in S. suis virulence. These findings contribute to clarifying the genomic characterization of S. suis serotype 8 and S. suis pathogenesis. Full article

(This article belongs to the Special Issue Bacteria Disease Research in Livestock and Poultry: Epidemiology, Pathogenicity, Drug Resistance and Control)

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