Recent Advances in Canine Mammary Tumors—2nd Edition

Dear Colleagues,

Canine mammary tumors (CMTs) are the most common neoplasm in intact female dogs, and about 50% of them are considered malignant. A CMT is a good spontaneous animal model of human breast cancer (HBC) research because it shares many similarities, such as epidemiologic, clinical, genetical, biological and pathological characteristics; additionally, their histological and molecular patterns are very heterogeneous. Different hormones and growth factors influence the occurrence of CMTs, but the pathological mechanisms remain unclear. In addition to circulating hormones, their receptors play a central role in mammary tumor formation (estrogen and progesterone receptors). Surgery is still the frontline treatment, but other therapies can be beneficial regarding patients’ survival. Advances in molecular pathways associated with cancer progression have highlighted several aspects in the field, and the development of new treatments may be promising for comparative and translational oncology.

This Special Issue aims to publish original research papers or reviews about canine mammary tumors, concerning their diagnosis, prognosis and therapeutics.

Areas of interest: CMT histological and molecular classification for diagnosis and prognosis; biomarkers; therapeutic approaches; experimental models suitable for CMTs; angiogenesis; metastasis and invasion; the role of the immune system and molecular pathways associated with CMT development and progression; and comparative and translational oncology.

We invite you to share your recent findings through this Special Issue.

Dr. Debora Aparecida Pires de Campos Zuccari
Dr. Luiz Gustavo de Almeida Chuffa
Dr. Guilherme Henrique Tamarindo
Guest Editors

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• dogs
• cancer
• biomarkers
• diagnosis
• prognosis
• extracellular vesicles
• therapeutics
• liquid biopsy
• comparative oncology
• translational models