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Animals
Special Issues
Control of Helminth Infections in Animals
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Control of Helminth Infections in Animals

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (10 January 2024) | Viewed by 1440

Special Issue Editors

Prof. Dr. Ruofeng Yan

E-Mail Website
Guest Editor
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China
Interests: Haemonchus contortus; Trichinella spiralis; Caenorhabditis elegans; vaccines; infection and immunity; diagnosis
Prof. Dr. Yadong Zheng

E-Mail Website
Guest Editor
College of Veterinary Medicine, Zhejiang A&F University, Hangzhou, China
Interests: cestode; pathogen–host interactions; infection and immunity; miRNA; diagnosis
Dr. Yang Hong

E-Mail Website
Guest Editor
National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention (Chinese Center for Tropical Diseases Research), Shanghai 200025, China
Interests: screening diagnostic markers, vaccine candidates and drug targets for schistosomiasis; pairing and laying eggs of schistosome; molecular diagnosis of parasites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Helminth infections in animals cause significant economic losses worldwide, with helminth zoonoses remaining a global public health problem. Currently, anthelmintic drugs are heavily used in livestock both to treat infections and as a preventive measure. However, many livestock in both developed and developing countries are now infected with drug-resistant helminths, and multiple resistance is common. As such, there is an urgent need for alternative methods of diagnosing and preventing animal helminth infections, as well as the development of new anthelmintics.

In this issue, we focus on the diagnosis and control of animal helminth infections. Our scope includes but is not limited to the study of the interaction between hosts and helminths, the biology of helminth development and metabolism, vaccines, and the application of management or technologies that could reduce helminth burden and/or egg output.

We invite original research papers and reviews related to the topics mentioned above.

Prof. Dr. Ruofeng Yan
Prof. Dr. Yadong Zheng
Dr. Yang Hong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neglective tropic disease
  • soil-transmitted helminth
  • helminth–host interaction
  • management
  • anthelmintics
  • vaccines
  • drug resistance
  • diagnosis
  • immunology
  • epidemiology
  • immune evasion

Published Papers (1 paper)

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Research

10 pages, 263 KiB  
Article
Diagnostic Efficacy of Plasma-Based Real-Time PCR for Schistosomiasis Japonica in Mice before and after Treatment with Praziquantel
by Cheng Chen, Xue Zhou, Qinghong Guo, Chao Lv, Yalan Tang, Qingqing Guo, Yang Chen, Kerou Zhou, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin, Yang Hong and Jun-Hu Chen
Animals 2023, 13(19), 3068; https://doi.org/10.3390/ani13193068 - 29 Sep 2023
Viewed by 1091
Abstract
The prevalence of schistosomiasis japonica in China is now characterized by a low epidemic rate and low-intensity infections. Some diagnostic methods with high sensitivity and specificity are urgently needed to better monitor this disease in the current situation. In this study, the detection [...] Read more.
The prevalence of schistosomiasis japonica in China is now characterized by a low epidemic rate and low-intensity infections. Some diagnostic methods with high sensitivity and specificity are urgently needed to better monitor this disease in the current situation. In this study, the detection efficacy of a real-time fluorescent quantitative PCR (qPCR) assay was assessed for schistosomiasis japonica in mice, and before and after treatment with praziquantel (PZQ). Our results showed that the sensitivity of the qPCR was 99.3% (152/153, 95% CI: 96.41–99.98%) and its specificity was 100% (77/77, 95% CI: 95.32–100%) in mice infected with different numbers of Schistosoma japonicum. After the oral administration of PZQ, mice infected with 10 cercariae or 40 cercariae were all Schistosoma japonicum-negative 6 weeks after treatment. However, the negativity rates on a soluble egg antigen (SEA)-based enzyme-linked immunosorbent assay (ELISA) were only 34.8% (8/23, 10 cercariae group) and 6.7% (1/15, 40 cercariae group) at the sixth week after PZQ treatment. These results demonstrated that the qPCR method had good sensitivity and specificity, and suggested that its sensitivity correlated with the infection intensity in mice. Moreover, this method had better potential utility for evaluating the treatment efficacy of PZQ in schistosome-infected mice than SEA-based ELISA. Full article
(This article belongs to the Special Issue Control of Helminth Infections in Animals)
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